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One of the benefits of our genesig MPX assays - no cold chain required.

@kaeren at one point India had more cases related to travel from Dubai than Dubai had cases so there's definitely an element of reluctance and likely denial of it's existence.

The geographic spread of MPX is broadly similar to covid at this point in the outbreak, although diagnosed cases are significantly lower due to it being intrinsically less transmissive and mode of transmission.

A lot of swabbing is being done at STD clinics but tests are being processed elsewhere. The DHSC can't have access to that many MPX assays as they are having to do some with generic orthopox assays - hence the increasing number of 'highly probables' they are reporting now which will have to be confirmed, effectively doubling the time to diagnose.

@wbafc up until last week Spain had identified 27 female cases, that more than doubled to 64 this week, so it's not staying in the initial MSM population now. Probably down to the increasing number of cases.

The global hospitalization rate for MPX is higher than covid @ circa 10% according to WHO, without wanting to sound callous it's the demands on health resources that would be the deciding factor on where we go from here rather than deaths. There are no circumstances under which a MPX patient can be treated alongside other non MPX patients. Not only that, the infectious period is a lot longer than covid requiring an isolation period of 21 days with some individuals still infectious even after that period.

The fact that we'll likely blast through 23k global cases in nearly half the world's nations in two and a half months exposes a massive public health failing, largely politically driven. It seems ignoring an issue doesn't make it magically go away.

Spain and Brazil, both announced deaths today. Spain also announced 64 female cases, up from 27. UK is also seeing more community spread outside of MSM.

San Francisco is finding MPX in wastewater and have declared a state of emergency.

22.5k cases globally, US > 5k

It's worth considering that when the contract was agreed in September 2020 cases were very low and labs will have been relatively quiet compared to the situation which quickly escalated by November and the country entered the second lockdown. The workload in labs will have been significantly higher by the time training was ramped up.

Interesting that they'll have started development of this assay (severe acute paediatric hepatitis was an issue as far back as February) well before they got started on the monkey pox assay yet it's released it a month later. Wonder if this has been developed in collaboration with a DHSC entity.

US reported 1048 cases yesterday.

@kilkennyted cheers, they were unable to be quorate for the EGM resolutions 11-20. This will be problematic for them at the next AGM if they can't scrape together 25% for EGM resolutions. Resolutions such as their authority to issue shares will expire before the 2024 AGM. They currently have 26 months from the 2021 AGM.

Currently around 10% of cases are hospitalized mainly for pain management.

https://twitter.com/WHO/status/1552286514956181505?t=DaO9isImtjeouI3hHmRqmw&s=19

It seems the DHSC doesn't have access to enough monkey pox assays and in many suspected cases are having to use 'generic' orthopox assays, classifying positives as highly probable MPX cases until confirmed by a further PCR. See attachment from UKHSA in this tweet.

https://twitter.com/SallyBourliakas/status/1552010417635041280?t=ZVbvP1H6G1ulQNjP_Z7hBQ&s=19

80% of shareholders who bothered to vote at the AGM voted in favour of the pay and ratification resolutions. It's like punching yourself in the face repeatedly and complaining it hurts. PIs have made their beds in that respect.

We can console ourselves with the thought that they've got SFA chance of pushing anything through at an egm for the foreseeable.

Just after my post the WHO declared MPX a PHEIC (public health emergency of international concern), WHO don't declare pandemics.

It's uncertain whether WHO will declare a PHEIC but the US are considering doing it themselves nationally after ramping up testing and finding a lot more cases than they expected including 2 infants yesterday . This includes looking at developing other testing options in addition to PCR. To the best of my knowledge they've never went with LFTs because they don't discriminate different orthopox viruses. However I suppose they could be deployed as an initial orthopox diagnosis at point of care with positives confirmed by PCR.

https://t.co/nAHDnPiNA6

France reports 541 cases, 60% increase in total cases to 1453. They're a passionate bunch.

If it ends up in court then the NDA goes out the window and becomes a matter of public record so at least we'll find out the basis of the dispute. Depends how keen either party is to go down that route. The legal costs while obviously not insignificant are nothing compared to the sums involved.

I'm getting the feeling that having swallowed the £30m inventory write off the company is unwilling to accept less than the outstanding invoices. As frustrating as it is we have a lot of the money from the contract already in the bank and not facing an imminent cash flow issue, the company likely feels it's now worth playing the long game with the DHSC. It's their fiduciary duty to recover as much money as possible from debtors.

We know all assays supplied were validated and now accredited by the DHSC, even if every assay supplied was duff we had enough inventory to replace them immediately under warranty.

It's yet again a waiting game but things will either have to progress or come to a conclusion eventually.

What I want to see is some/any M&A, I want to see them actually spend some of the money they're so sure is actually ours. Why not make an acquisition in the US instead of dicking around trying to get a foot in the door organically because that's been a monumental failure.

Imo

I voted against those resolutions as well but the votes are cast and the course is set. The choice is hold or sell up and move on. I've got better things to do than bleat about it day in day out.

The could only get 13% participation from all shareholders, hardly a ringing endorsement. They'll be in exactly the same situation next year unless they can engage IIs.

Same ones who voted their remuneration through, even taking into account Bio's holding more PIs voted for than against. No more whinging about their remuneration and the man in charge on here then.

It will be rnsd in any case johnny, I don't think the remuneration and ratification resolutions are a sure thing for the board, will likely be at least close considering low shareholder turnout.

@johnny19, outcome to resolutions will be announced as it goes. Still trying to capture votes at the AGM, board meeting this afternoon . Straight up majority required at second time of asking. Looks like only around 13% of shares in issue voted.