AstraZeneca as partner??6 May 2020 10:23
Could the COVID19 partner be...AstraZeneca? Here’s why I think it could be
‘Astra’s chief executive Pascal Soriot revealed the company was collaborating with partners on developing a monoclonal antibody treatment for Covid-19 which could halt the disease in its tracks, providing a bridge towards a vaccine’.
https://www.thisismoney.co.uk/money/comment/article-8278545/ALEX-BRUMMER-life-sciences-firms-left-loop.html
‘AstraZeneca also disclosed antibody collaborations with external partners, saying that The Chinese Academy of Sciences, and Vanderbilt University Medical Center had provided genetic sequences for antibodies they have discovered against SARS2-CoV-2 for further in silico and in vitro assessment, while the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) and the University of Maryland School of Medicine were conducting preclinical safety and efficacy assessments of antibody candidates discovered by AstraZeneca through internal research.
AstraZeneca prevailed over several other pharmaceutical giants—many of them U.S.-based—also seeking to partner with Oxford in the global manufacturing and distribution of its vaccine, the Financial Times reported, citing an unnamed source.
https://www.genengnews.com/news/astrazeneca-joins-u-of-oxford-and-spinout-to-develop-covid-19-vaccine/
Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can have monovalent affinity, in that they bind to the same epitope (the part of an antigen that is recognized by the antibody). From Wikipedia
‘Continued development of CDX with a global pharmaceutical company involving manufacturability assessment and follow-up tests of the antibody’
‘Hemogenyx to use its advanced humanised mice to develop potential treatments for COVID-19 and other emerging pathogens’
‘Our humanised mice have proven to be an immensely useful tool and have allowed the Company to enter new areas of drug development, including for autoimmune diseases and diseases caused by viral infections, in particular COVID-19." ‘
Hemogenyx Pharmaceuticals plc (LSE: HEMO), the biopharmaceutical group developing new therapies and treatments for deadly blood diseases, is deploying its groundbreaking research and technologies to develop potential treatments for COVID-19.
‘Using its humanized mice, the Advanced peripheral blood Hematopoietic Chimera ("ApbHC"), which were developed to model blood and autoimmune diseases and to test treatments, Hemogenyx will seek to discover human neutralizing antibodies - antibodies that are typically developed by the human immune system to neutralize invading viral pathogens - that could be used to fight SARS-CoV-2 (the virus that causes COVID-19) infections.’
‘Prior to the appearance of COVID-19, Hemogenyx had been working independently and with a number of pharmaceutical company partners to utilize the exceptional features