Member Info for Scinv_temp

Sure sure. As you jave seen for the millionth time, it doesn't matter how I write. The responses are always the same.

So if all goes well (availability, company deciding again stick to their own, other issues) the phase 3 part of activ 2 could include the autoantibody status in the inclusion criteria or split the primary outcomes into +/- autoantibodies

All of them except the activ 2 (because there they actually check). So hopefully, there won't be any more issues with availability for the rest of the activ trial.

Adn today we see there can be issues also with the wiring, and that is in fact not surprising, since clearly yes ifn seems important esp in covid, but only in a subset of sever patients we see the autoantibodies for example.

Mike that fact that you are asking this question means you do not understand anything about science or investments.

Here we go again, trials without selecting patients based on scientific evidence is low confidence, trials with a good rationale in selecting patients are higher confidence.

The autoantibodies story and their role in other respiratory viruses has been known for years, it is their role in covid that was pointed out at least since last October.

And I'm telling that

1. I explained it AGAIN before your latest comment
2. I had explained it last night but the comment was reported away
3. I had explained in part befor to Ghia (before this paper) and copy/pasted it again last night, that too was reported away
4. I have been very detailed and to the point on the vast majority of occasions since last September but every time someone does not agree all the true nature of this board and the vast majority of its "contributors" comes out, no.matter what the detail or tone of my post is.

But you already know that.

Cut the BS Ghia, I explained it in more details last night and all the comments were reported into oblivion. Let's see if the latest one stays

I did explain it. The reseptor is the switch, ifn is the signal that turns it on, tyk2, stat2 (and other proteins in the cascade) is the wiring to the bulb (Interferon Stimulated Genes, ISG). In addition to other findings, they find that ar least to some extent there can be defects in the wiring.

It is a gamble because, as suspected, ifn response can be disrupted in different ways and we don't know what the benefit of ectopic ifn (so ifn we add to te system) is in each of these cases and that is why giving it to patients without selecting those that seem most likely to respond is a gamble.

What both sides of rhe argument?
This research claims that due to inhibition of function downstream of the receptor
"cells were highly resistant to ectopic induction of IFNs"

It is 100% objective that this is what they claim, and I did not post the article, someone else did

I have explaoned this in more detail last night but the people here pretend to care about science but report into oblivion posts that actually explain it, if it does not fit their narrative.

Downstream of the receptor means that ifn turnns the switch (receptor) on buy the wiring after the switch is defective. So in the cases where there this is a dominant mechanism, it wouldn't matter if ifn is there or not.

That is why sng own trials sre a blind gamble, at least in activ they will check for autoantibodies

And then the groupies follow up with the "excellent post"
Lol this is hilarious

Let's hope they don't mess up the activ 2 trials any more than they already have with the availability cause the trials sng is doing themselves is pure gamblimg, DESPITE having much of this informstion since a long time ago, with much of the rest easily predicted by anyone with the slightest hint of compentence :)

Yeah man. Science! Right on!
Tyk2 and stat2 are downstream of the receptor. These defeciancies are after ifn was supposed to do its job. So this is distinct from autoantibodies for example which act upstream.

That's not fair Massive. I'm just trying to describe some potential scenarios, while trying to remain true to the company. I've even made an amendment below.

[... "We have a massive stocklpile in anticipation and hope that the truth would leak and we will make our treatment available to everyone imminently! From today, we put a stop to all respiratory viruses. No more profiteering from big pharma with their purposely inefective and mind controlling treatments and vaccines.", RM will say.

11 months later many millions of treatments at affordable prices become available to every person on the planet who needs them. ... ]

About 20 min but I had some issues with page on mobile.
:p

It will be secretly approved tomorrow just for the elite! But the secret of this miracle cure, only given in the most exclusive rooms of the most exclusive clinics will leak. There will be a media storm of this news, demonstrations on the streets and outside the hospitals for the rich.

RM will swiftly organise a press conference. There, we will find out that under threat they could not speak of it publicly. But the truth has prevailed! Now everyone knows, they cannot hide it anymore. "From today, we will make this available to everyone. Today, we put a stop to all respiratory viruses. No more profiteering from big pharma with their purposely inefective and mind controlling treatments and vaccines.", RM will say.

A week later billions of doses at affordable prices become available to every person on the planet who needs them. A year later, deaths from viral respiratory infections drop by 96.32% worldwide and RM is a guest at the White House to be honored with a medal for his achievements. The largest media networks from around the world are covering the event as RM approaches the podium to accept his medal from the US President and address the public. A door onbtye side of the stage area is creaking open. Two men slowly approach the podium and kneel before RM. It is George Soros and Bill Gates. With tears in their eyes they cry "We confess". At last all comes out in the open! The truth about microchips, the illuminati, the Bildeberg club, everything! All of a sudden, a strange smell envelops the room! A faithful investor, we'll call him Kime, is staring at the ceiling, it was time to wake up and he had just farted.

Oh dear.
But, hey, rejoice! They already have the delivery sorted out!
:P

I hope that we will find out the full details of what happened with remdesivir one day. I still think it was and remains a scandal

As the most urgent phase is diminishing and other treatments are available, other details become more important and the process start lean towards "business as usual" (though not there yet) where every little detail is scrutinised to exhaustion, and also others have time to catch up

It is worse than that Fruits, because sng had (still has?) the chance to reach approval with the tailwind of the urgency of this pandemic. This was a no brainer, accept a lower price and make sure you have gov, mhra, media fully on your side and with funding/other that surely would have been available even if the margins weren't great. But make sure you get that approval and in terms of share price, fomo would have taken care of it. This all assuming that it does work well and they have a good grasp of when and to whom should be given. But even that wasn't an issue with monoclonals. Companies wanted early apnyway, it is the health authorities that wanted in more severe cases first, because simply you never know and because in the beginning there weren't very large quantities available anyway (this is not to be compared to checking behind the sofa pillow to get to those 200 doses though, to keep things in context). However, govs and authorities are not stup1d, so long as the companies are not unreasonable and there is a strong rationale behind the treatments, they supported, evem through failed trials. The only exception to this is remdesivir, which was and remains a mess.

Anyway, this was so obvious, I have described it *precisely* since the first time RM mentioned remdesivit pricing and things got out of hand, many months ago.