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Yep, in from March. Watching the science literature .... as ever.
What a rag of a paper.
Was there any follow up on the 30 something female that was shown being dosed on the BBC report? I can't remember her name.
Doc - I would agree - due diligence has been done and this is a very solid investment. The rest is down to Nature - and if we understood that we wouldn't be here in the first place.
I am sure like many others this board has been a welcome forum for exchange of ideas and opinions for a while now - I know it has given me a welcome alternative click to the BBC News site - again.. Now we just has to wait to see how efficacy, politics, the virus etc etc plays out.
GLA!
BBC...sigh...and that earlier numpty who sure, urged caution with hopes for treatments, but lumped SNG in with the same calibre of hydroxychloroquine was a joke.
As ever, apologies if posted already. Just spotted this yesterday reporting on study out of Southampton in collaboration with Synairgen.
https://www.fiercebiotech.com/research/synairgen-s-inhaled-interferon-for-covid-19-enhances-short-harmless-version-virus-entry
pmjh, I am sure you have already posted this..
Again, apologies if posted before but this was interesting. Open access so can be read by all.
https://www.frontiersin.org/articles/10.3389/fphar.2020.592543/full
Oh yes, bottom right hand corner - 'Cloud with a silver lining - Synairgen shares soar' - a SP chart and a statement that shares rose 2200% between February and August making it one the pandemic's biggest success stories. Its interferon beta treatment for Covid was given through an inhaler....
That is it, but at least it is in there. Now back to 10 pages of vaccine news....
Forgot my asterisks...
I think Handjob might use treatment and vaccine interchangeably.
Sorry about the typos - long day!
Yes this is very early days - there are a wealth of synthetic 'antibodies' and nano bodies have been very popular for quickly engineering to bind a target - usually human protein targets. But this is a long long way off getting into the clinic plus it targets one epitope on the spike unlike natural antibodies that have more variety. But all good work on biologics and really pushing this field.
The interferon route is like flicking a switch - it activates all the clever immunology downstream we can't even hope to mimic. There has been a lot of emphasis on mutations in the spike that effect ACE2 binding but I am not sure so much is known about the mutations the virus uses to tame the interferon response. I think these involves nips and changes in a different quite variable part if the viral genome (ORF3b - https://www.sciencedirect.com/science/article/pii/S2211124720311748) - sorry a bit technical but this was a great paper.
My feeling is that now the vaccine euphoria has died down, the world will slowly wake up to the scale of the task ahead. It is clear there is room for treatment as this rolls on and on. It is clearly a marathon and that is what will breed success here - assuming efficacy is close to what they saw at phase II.
Still invested and about to watching the webinar on IFN-1b - let's see what they have to say...
A rainy day in the UK with not much to do but think - which is a good thing.
As an academic I have witnessed a swathe of colleagues unable to resist the siren of the passing bandwagon and get some funding for 'COVID' research, not having ever thought about his before March 2020. It is quite frankly embarrassing and amateur.
I guess this is why I am am fan of this stock as this company has quietly worked away in a related arena before this explosion. This market tests the metal for sure but the science is solid and that is a sense the limit of ALL the discussions here. Now it is doing the 'experiment' and we await the result. Proper research, solid hypothesis and now testing this.
Why I do this job? - because we always await a result ... don't just think COVID - COPD is huge.
Yep still here - all I will say is vaccine, great! But the logistics of shipping vaccine in liquid nitrogen or storing in -80C freezers (your home ones are -20C, these -80C beasts are a different story) are horrendous - at this scale. The UK can't even get enough flu vaccine out in any numbers at the moment, and those are kept in a 4C fridge in Boots. I panicked and sold a few, then bought again after reading COPD literature and thinking long game - whether months or many years. I don't want to detract from the current crisis, but COVID-19 has given SNG more limelight than they would have otherwise got and their broader approach to respiratory viral infections will be firmly in the spotlight.
The market euphoria seems to have calmed down and Dow is back down again.
No - we don't know if this mutation has any relevance or impact whatsoever and mutations happen all the time. Killing 17 million mink, now that is upsetting. It is another media sh*t storm. From New Scientist website below.
What do scientists say?
Francois Balloux, a professor of genetics at University College London (UCL), took to Twitter to describe the report as âhighly problematicâ. He said his colleague Lucy van Dorp at UCL has already documented numerous coronavirus mutants arising repeatedly in mink, none of which are concerning for humans. The claim that this mutant may be resistant to a vaccine is âidioticâ, he said. Such mutations might emerge in humans once we have a vaccine but wonât appear in mink, he said.
Other scientists echoed his views. James Wood at the University of Cambridge said he understands that the mutation is on the spike protein, which the virus uses to enter cells and which induces an antibody response. However, âthe true implication of the changes in the spike protein have not yet been evaluated by the international scientific community and are thus unclear. It is too early to say that the change will cause either vaccines or immunity to fail,â he said in a statement.
Virologist Ian Jones at the University of Reading in the UK said that it wasnât surprising that the virus had mutated, as it would need to adapt to mink. Denmarkâs precautionary action would make it less likely that the new virus would spread widely in humans, he said in a statement.
Is the virus likely to spread to other animals?
Yes, very. More than 60 mammal species are known to be definitely or probably susceptible, ranging from gorillas and chimps to foxes, yaks, giant pandas and koalas. Even some whales, dolphins and seals may be able to catch it.
Why did nobody see this coming?
We did. Even before this happened, virologists were concerned about âreverse spilloverâ, which is when humans pass the virus on to domestic or wild animals. That could be a problem for the animals as some species fall ill and die. It could also spell trouble for us, as animals could become a new reservoir of virus and make the pandemic even harder to control. Animals could also be a crucible for the virus to mutate into another novel coronavirus.
Read more: https://www.newscientist.com/article/2259178-is-a-dangerous-new-coronavirus-strain-circulating-in-farmed-mink/#ixzz6d7tbmDoC
Pmjh, looks like neuropilin-1 receptor enhances viral entry into cells and you have a lot of these in nasal cavities. These studies have been popping up over the last few days
https://science.sciencemag.org/content/early/2020/10/19/science.abd3072
Nice spot Ducati2. Flow of news is certainly ticking up.