Stephan Bernstein, CEO of GreenRoc, details the PFS results for the new graphite processing plant. Watch the video here.
It is getting a bit 'Works every time, 60% of the time'. Which reminds me, I must go and watch that film again.
@gkb47 'may help prevent those with an issue with their innate Interferon response (which I keep saying should be screened for) from becoming seriously ill'
Yep can't agree more on the screening front.
Good find. This paper is deposited in the NIH repository, so nothing to do with them other than that. It is a review and authors are from Singapore/India and it is in an okay journal. All positive but no big reveal here??
What people always fail to understand is exponential growth. My father in law gave the best example of how it catches you. Take a garden pond that you like to keep clean and let's say the algae doubles every day. Initially we all know it is no problem and creeps up but the neat example is to think backwards and imagining that you see it one day completely 100% green and overrun. Yesterday it was half that, the day before that a quarter and before that an 1/8 of the pond and you didn't really notice, just a bit murky.
3 days....
Vax rollout huge success but plenty left to overwhelm a very tired NHS who will struggle to generate the energy to keep doing this.
We are run by clowns.
As ever, science amazingly fast and mechanism of rare ChAdOx1 (Ox-AZ) vaccine events already being delineated. Should be free to read - or just the conclusions. Came out of Leeds as well.
'Mechanisms of Immunothrombosis in Vaccine-Induced Thrombotic Thrombocytopenia (VITT) Compared to Natural SARS-CoV-2 Infection'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133385/
Have a good weekend all.
xviolet - PML.
Woodstock - stick with it, there are plenty of us who are looking at the science and posting articles as they arise. Just ignore the background noise. I have been posting since early 2020 and this is still a most fascinating field. I count over 80 papers relating to IFN now and SC2 and although none of us can predict geopolitical gaming, this has all the signs....
Thanks for the post Mr Crumpet!
May 2021 publication - may have been posted but not by me...it is pre-review. long term holder and amongst many long term holders here that I have enjoyed discussions with over the last 14 months.
'SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways'
In plain English the discovery of yet more ways the virus specifically damps interferon response - on top of the others that have been posted here over the last 12 months. Has been highlighted in another paper I think.
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.27050
A report from Iraq - all credit for to them for producing this - discussion good and lots of references that we have posted here over 2020-2021. https://www.spandidos-publications.com/10.3892/br.2021.1419
Yes PMJH was a great poster.... I am still a firm believer in the science and I still hold, just not posted much. I will flag papers that I spot but the interferon case has been made in my eyes. Just watching paper gains and losses wax and wane but trying to ignore it for now. This virus is going to be circulating for years in one form or another and this past 12 months was just the starter. I think the cost of this treatment will fall once production becomes optimised and then it moves closer to that off the shelf feel - although it is rather too potent to ever reach that sphere. RM said it needs a fire to put out - that was the nugget for me and we must still wait and see. Then there is long covid... I know mild cases who are still fatigued and wiped out. This treatment might prevent that, who knows.
Some honest telling 'it as it is' for a change and unfortunately I suspect is fairly close to the mark. There is no doubt in my mind whatsoever that treatments are going to form an integral part of a multi-pronged strategy to deal with this as we move forward.
Sir Graham Brady tells Radio 4's PM programme there is a "fundamental question" stemming from the fact an endemic disease "might be coming back every winter for the foreseeable future".
"If you are going to respond to say that the only reaction to that is to close down the country, to prevent people from seeing their families, to stop people from doing business and earning a living," he says, "then I think that's an apocalyptic vision that would definitely cause far more harm in terms both of deaths and mental health problems and economic devastation than the alternative.
"So I think it's inevitable if we see this coming back in future years and future winters, which is entirely likely, we are going to have to find ways of living sensibly with a very nasty virus, which will include some restrictions.
"But I don't think it's plausible to suggest that lockdown is the answer to that."
Many thanks Infoking, nice find.
Yes, enjoy the weekend all :)
Advanced on-line articles like this often appear with dates a few weeks ahead.
Not posted for a while but I am still in since May 2020.
Okay a single patient, but a hospital in Wuhan reports inhaled interferon (alpha in this case) as part of a ****tail that was successful with someone who was clearly seriously ill.
Successful recovery of a patient with multiple myeloma from severe coronavirus disease 2019 (COVID-19) pneumonia during the first chemotherapy cycle: A case report
By:Li, ZP (Li, Ziping)[ 1 ] ; Chen, Y (Chen, Yan)[ 2 ] ; Yang, BH (Yang, Bohan)[ 3 ] ; Song, HP (Song, Haiping)[ 4 ] ; Chen, WX (Chen, Wanxin)[ 1 ] ; Zhou, H (Zhou, Hao)[ 1 ]
EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume: 21 Issue: 4
Article Number: 392
DOI: 10.3892/etm.2021.9823
Published: APR 2021
Abstract
A continuing outbreak of pneumonia associated with the 2019 novel coronavirus (2019-nCoV) was initially described in Wuhan, China in December 2019. Weak and elderly individuals, and those with chronic diseases such as hematological malignancies are prone to develop severe pneumonia. The humoral immunity of patients with multiple myeloma is prevalently low, and their inferior immunity further deteriorates during chemotherapy. For patients with onco-hematological malignancies infected with 2019-nCoV during the first chemotherapy cycle, the clinical treatment experience is lacking. The present study is a report of a 61-year-old patient newly diagnosed with multiple myeloma in the key 2019-nCoV outbreak area, who suffered severe 2019-nCoV pneumonia during the first chemotherapy cycle. The present case report demonstrated that a rapidly progressive and severe form of pneumonia was a specific clinical feature of COVID-19, especially in immunocompromised patients with cancer. The treatment strategy combining timely suspending chemotherapy, early intervention using intravenous immunoglobulin, interferon alpha inhalation and oral antiviral drugs was effective. Therefore, in the pandemic environment, it is strongly recommend that the risk of 2019-nCoV infection is assessed prior to chemotherapy.
Apologise for typos.
Hi all, I have not posted for a while but I am a long term holder if 12 months qualifies. The ups and downs are unsettling but I try to remind myself that ultimately this is the first time that this therapeutic, very potent biomolecule, has been formulated as an aerosolised product. So mil self-reassuring broader view is this may very well represent a step change in technology for tackling respiratory infections and the company is well positioned for years ahead. Who can predict short term movements in this dynamic crisis but mu underlying view is the scientists involved sat down (years ago) and simply said no-one has done this yet - i.e administer the molecule directly to the lungs. Why? Well they just haven't yet and they were first. So we could be sat on a game changer or wider paradigm for this kind of intervention. Just musings - back to that fantastic posting of Jefferson Airplane. Will post if I spot any more publications (before others!).
Thanks Tiger
Well if you want to get depressed just watch the Adam Curtis film Hypernormalisation on iplayer. It is circa 2016 but new films coming out next month. He also did Bitterlake I think. It gives you a flavour of leaders not being in control - and then some.