Annnnyway30 Oct 2019 08:02
Back to SNG related matters.
Two PXS news releases today, a big presentation focusing heavily on LOXL2 from the Aus Biotech conference, and a related ASX update.
The most relevant bits from the update are:
"Pharmaxis has recently presented data at scientific conferences and in scientific publications detailing its unique proprietary assays that, for the first time, allow all of the LOX enzyme family to be measured in serum and tissue, even at very low levels. These data demonstrate that LOXL2 in particular has a relatively fast turnover in human serum and suggests that an effective drug will need to both penetrate fibrotic tissue and be present in concentrations high enough to inhibit LOXL2 at all times. Pharmaxis has used this unique assay technology in the development and assessment of all its current LOX and LOXL2 inhibitors."
"Whilst there are several excellent publications demonstrating the increase in LOXL2 enzyme levels in patients with fibrotic diseases of the lung, liver, kidney, heart, and some cancers, the importance of LOXL2 has been put in doubt by the failure of the one competitive LOXL2 inhibitor drug to have been trialled in patients; Gilead’s LOXL2 antibody simtuzumab. Gilead
commented in the publication of its failed IPF study that their lack of an assay for LOXL2 inhibition limited their ability to confirm adequate target inhibition.
The risk sensitivities of potential commercial partners for our LOXL2 inhibitor program were understandably heightened by the historic simtuzumab clinical failures but importantly, the work Pharmaxis has undertaken in assay sensitivity has provided very reassuring data. Over the course of this year, we have been able to reanalyse samples from existing studies and conduct new preclinical studies that have clearly shown the link between LOXL2 inhibition in diseased organs, a
reduction in collagen crosslinking which is a hallmark of fibrosis and clinical effect as measured by the area of fibrosis. This data has energised the partnering process by underlining the relevance of LOXL2 and the superiority of our compounds. We are currently pursuing a number of different partnering options to enable this drug to commence phase 2 efficacy studies in patients with IPF or NASH.”
Partnering process still listed as to conclude H2 - 2019 in the presentation. So all looking good. Looks like the market was basically spooked by the Gilead failure but they have the data to show their drug is top notch and is much less likely to suffer the same failure due to testing they've done.