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On 17th January the BBC reported: Early evidence suggests the variant of coronavirus that emerged in the UK may be more deadly, Prime Minister Boris Johnson said.
Some German scientists then disputed this. So over two months later the BBC reports that Merkel has found out too.
Croda bought Avanti Polar Lipids last year for their lipid nanoparticles, the delivery mechanism for all mRNA vaccines. Croda is struggling to lift manufacturing capacity to supply current demand from vaccine manufacturers. It would not be a good idea for anyone, especially upset Eurocrats to upset the Croda management right now.
https://www.crodahealthcare.com/en-gb/news/2020/07/croda-strengthens-position-in-life-sciences
Apologies if I have missed this but do we know if Mologic use affimers for their LFT?
https://avacta.com/avacta-and-mologic-enter-research-and-product-development-collaboration-agreement/
https://twitter.com/avacta/status/1358672572473348098
There has been no other Avacta announcement on other diagnostic developments to my knowledge.
However, Cytiva have announced new locations in Wales, Germany and China for diagnostic tests and there may have been some undisclosed agreements with Avacta.
https://www.cytivalifesciences.com/en/us/news-center/cytiva-strengthens-support-to-diagnostics-industry-with-new-labs-services-and-supply-chain-enhanceme-10001
The May video update available on the Avacta website describes some of the diagnostic tests which Avacta have developed.
https://www.sciencemag.org/news/2017/02/mysterious-2-billion-biotech-revealing-secrets-behind-its-new-drugs-and-vaccines
Oops. Forgot to post the link.
This article explains how the Moderna mRNA enters the cell.
The sixth paragraph from the end says Moderna are researching alternative delivery systems. These could include affimers.
In any event, this development by Moderna is a phenomenal achievement and presages significant medical advances in the future. Avacta is well positioned to work with the company. Earlier in the year posters here quoted scientists who said the attempted Moderna vaccine would take five years and would probably fail.
This indicates that mRNA is being used to deliver affimers rather than the inverse. As with the covid vaccine, the mRNA will instruct cells in the body to manufacture affimers which will be the therapeutic.
Avacta signed contracts with Moderna in 2015 and again in 2019. And Moderna have other products undergoing clinical trials other than the covid-19 vaccine.
It is not known how the Moderna mRNA is protected from degradation. It looks like Moderna is keeping the technology secret.
If MRNA is not protected it quickly breaks down. The Pfizer vaccine is protected by freezing it to -80 Celsius which means it is difficult to transport.
Arbutus Biopharma believes Moderna is using its LNP technology without paying and has sued.
Recently the U.S. Patent Trial and Appeal Board rejected Moderna’s challenge to a patent owned by Arbutus Biopharma ABUS +4% related to the lipid nanoparticle (LNP) technology that is crucial to Moderna’s mRNA medicines.
LNP means small fat particles which surround the individual mRNA molecules. Moderna say they are not breaking the Arbutus patent but presumably declined to explain their secret methodology to the court.
It is probable that Moderna have invented a different LNP formulation. But it is not impossible the mRNA molecules are protected by a specially created affimer designed for this purpose.
Coronavirus testing is hampered by the fact that accurate tests do not produce instant results, while rapid diagnostics are less reliable. Public health experts say the holy grail is a test that is both fast and precise.
We need to be funding not just vaccines. I think another major area we need to be looking at is diagnostics
A greater focus on diagnostics would help identify asymptomatic carriers who may be spreading the illness unwittingly, Dr Gounder said. An estimated 40 per cent of all people infected with Covid-19 do not have symptoms, according to the US Centers for Disease Control and Prevention.
Dr Gounder said experts believe younger adults are more likely to be these silent spreaders. “You can’t possibly curb that without testing,” she added.
https://www.ft.com/content/c56b93de-d5f9-4c1f-af66-44cf9a91b898
Donald Trump’s flagship vaccine programme Operation Warp Speed should be overhauled to focus on coronavirus testing when Joe Biden enters the White House, according to a member of the president-elect’s pandemic task force.
You can contact the Advertising Standards Authority with an explanation as to why the advertising is misleading. They will issue a ruling if they agree. Just one approach to them is sufficient but it should be carefully prepared.
There was already a connection between the Avacta board and the Bill and Melinda Gates Foundation.
https://www.insidermedia.com/news/yorkshire/new-chairman-appointed-at-avacta-group
This is significant information. Thanks for posting.
Ferrier was selected by her electors, not appointed by the government. It for them to depose her.
In the 7investing podcast number 11 at about 14 minutes the contributors are discussing the future of healthcare and predicting this will include a device in the toilet bowl similar to the ones Deepverge has been marketing for communities - and linked to an app with a traffic light type message. Green is OK. Amber is get this checked out. And red is make sure you check this out. And with more specific details of what the detector has found.
Is this something suitable for Deep Verge in the future?
In the 7investing podcast number 11 at about 14 minutes the contributors are discussing the future of healthcare and predicting this will include a device in the toilet bowl similar to the ones Integumen have been marketing - and linked to an app with a traffic light type message. Green is OK. Amber is get this checked out. And red is make sure you check this out. And with more specific details of what the detector has found.
Is this something suitable for Deep Verge in the future?
It’s a pity no one has taken on that project.
Remdesivir may well zap the virus when it has recently been acquired - although it is in short supply, expensive and only authorized for serious cases. If Trump, Flotus and Hope Hicks have all made spectacular recoveries next week this could be the reason. Although off-label prescriptions will not be publicised.
This will be a significant step forward for Opti if the clinical trials are successful.
Very many Opti shareholders have capitulated in the past two years so the share price is now low.
The IND adds to the recent Sweetbiotix contract to add further interest.
From The Times: Other than King Edward VIII’s abdication in 1936, The Yorkshire Post is not known for its world scoops, but it managed one yesterday. It reported that Omega Diagnostics is one of three companies contracted to make a Covid-19 antigen test developed by Avacta. That came as a pleasant surprise to investors and pushed the stock up 1.9 per cent to 81p.