Member Info for MrCrumpet

The sun has come out - does correlation point towards causation? Remember not to feed the trolls and the Filter button is your friend!

Snoozefest from SNG perspective.

Now taking questions from journalists

We are still listed under research and development

https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19/treatments-vaccines/treatments-covid-19/covid-19-treatments-research-development

Treatments just talking about MABS

https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19/treatments-vaccines/treatments-covid-19/covid-19-treatments-under-evaluation

So far about Pfizer vaccine in teenagers

That makes sense - thanks

What a strange stream of small buys. Anyone seen that before?

£134k

Now I feel better about my buy at 0.45 this morning

People like whole numbers and it looks like 40 may act as support.

Largest amount I can get on a quote to sell this morning is 100 shares. Any more and no one wants it.

The real issue here is that it failed to work in peoiple who were relly sick as well so it is no use in any situation. The FDA can't say that about SNG001, so I wouldn't get too worked up about a dressing down from the FDA if ACTIV-2 isn't great.

So they are slow at updating their website. As much as I want it to be something to get excited about I really don't think it is. Of course I'd be more than happy to be proved wrong but fully expecting no good news until P3 readout.

Some background detail on what Nominative ATU means.

https://partners4access.com/france-to-place-restrictions-on-nominative-atu/

Sorry to be a party pooper.

And that is why I am holding. If you are getting an itchy finger hover over the sell button I can highly recommend learning the basics of technical analysis and charting, and start doing a bit of trading (even if only using the demo function with pretend money). Trying to trade rather than invest really does give you some perspective and despite what twitter rampers might say it's not all easy money. Highly recommend following Noel Borg (Borg74) https://twitter.com/Borg74 and Jarvy55 https://twitter.com/Jarvy55/status/1320424651466702850 on twitter to get you started.

Keep your big holding here and see if you can make a little beer money elsewhere :)

Wish I could find some shares I forgot I had...

Investors are biding their time, awaiting phase III outcome
A key feature of SNG001 is that it can be self-administered at home, bringing a number of benefits. Patients are more likely to self-administer at an earlier point in the course of the illness, potentially preventing a more serious progression of the virus into the lower respiratory tract. And as a face-to-face meeting with a health care professional is not required, SNG001 can minimise the risk of onward infection, lower the burden on healthcare systems and reduce the need for economically costly lockdowns.

Though the trial results were encouraging, it seems investors are biding their time, perhaps waiting for the outcome of the phase III clinical trial later this year. A further consideration is that commercialisation is some way off, as the findings must first be submitted for peer review.

Positive results from the phase III trial (SG018) could be a game changer. With a positive result, broker finnCap is expecting “significant revenues to accrue from government orders in 2021/22”, as the clinical need for a targeted broad-spectrum anti-viral treatment for hospitalised Covid-19 patients remains significant, both domestically and globally. FinnCap is holding its share price target of 505p, while waiting for the read-out from the phase III trial.

Synairgen is currently unprofitable, and reliant on revenues raised from issuing shares to cover operational costs, which dilutes shareholdings. More reassuring is that the company has been debt free for five years, and its assets more than cover its short- and long-term liabilities, indicating a stable and experienced management team.

Demand for coronavirus treatments will remain strong, as the continuing waves of infections around the world indicate. Over the past week, Synairgen’s shares have continued to slide and are now looking quite cheap at 109.47p as trading opened this morning (10 May). Watch out for those trial III results later this year, as the shares could yet reach finnCap’s 505p price target.

Positive coverage from The Armchair Trader

https://www.thearmchairtrader.com/synairgen-investors-phase-iii-trial-results/

Small cap respiratory drug developer Synairgen [LON:SNG] has reported positive results from its phase II clinical trial of inhaled SNG001 in Sars-CoV-2 infected patients. Shares nevertheless took a tumble after the announcement on 30 April, falling more than 25% from 150.66p down to 111.90p on 4 May.

Shares had been trading down, giving a return of -26.56% year to date. Over 12-months, the return is 59%, though this includes a 420% surge in share price in July last year, from 36.28p on 17 July 2020 to 188.87p three days later on 30 July, after Synairgen announced positive results from a clinical trial of SNG001 in hospitalised Covid-19 patients.

Synairgen’s COVID treatment IS working
The phase II clinical trial results may have failed to impress investors, but they did indicate the potential efficacy of its inhaled interferon-beta treatment in those with severe illness, demonstrating a reduction in the rate of hospitalisation in Covid-19 patients. Analysis of the combined data from the hospital and home cohorts showed that the more breathless patients are three times more likely to recover on inhaled SNG001 than placebo, in both home and hospital settings.

Tom Wilkinson, Professor of Respiratory Medicine at the University of Southampton, described the trial as “very successful”, adding that “although the vast majority of non-hospitalised patients had very mild symptoms, the effects of SNG001 on the small group of markedly and severely breathless patients indicated who might be benefiting most from SNG001.”

The vast majority of patients only had mild Covid symptoms, with two (3%) hospitalised during the treatment period, both on placebo. This limited the potential of assessing treatment effects in this cohort, as the prevention of severe lower respiratory tract illness could not be determined. However, the trial results were encouraging and reinforced confidence that the international phase III study of hospitalised patients requiring supplemental oxygen is on track to deliver positive results later this year.

Indeed, just look what happened after the drop on vaccine news. Patience is the name of the game here. And if you want a bit of fun in the meantime learn technical analysis and do a bit of trading elsewhere. At the very least TA will teach you buy in points.