Seed Health2 Aug 2023 17:37
Update re their, albeit small, in vitro trial
Extract
SH-DS01 capsules containing a 24-strain probiotic mixture encased in an Indian pomegranate (Punica granatum) outer envelope were obtained from Seed Health (Los Angeles, CA, USA). SH-DS01 contains the following strains:
Lactiplantibacillus plantarum SD-LPLDL-UK
amongst others - i've deleted others because of space constraints posting here
Our study has certain limitations and leaves a number of open questions. First, it uses an in vitro system as a model to approximate the human gut. This artificial system can introduce confounders into the model that make biological interpretations difficult. However, we contend that in vitro models using complex fecally derived communities can provide useful information regarding the short-term transit and activity of a synbiotic in the gastrointestinal tract, noting, however, that the use of a fecal community from a single individual does not capture interindividual variations in microbiome composition that may play a role in stress recovery. Second, our incubation times reflect roughly a 2-day exposure time and do not allow conclusions to be drawn on the long-term impact of synbiotics on recovery after stressors. Finally, transfer between reactors induces a bottleneck event that may modify community succession in a manner that would not occur in a true gut ecosystem. Nevertheless, the results shown here indicate the beneficial effects of a specific synbiotic product on the functional recovery of the gut microbiome in vitro following stress.
Overall, these experiments demonstrate the acute impact of alcohol and broad-spectrum antibiotics on the fecal microbiome in vitro and the potential for a microbial consortium to mitigate environmentally induced stress on the structure and function of the human gut microbiome in vivo. We contend that our results demonstrating the recovery of key aspects of healthy gut microbial function, specifically SCFA production, are relevant to predicting the potential effects of a synbiotic in humans. A well-designed clinical trial with deeper sequencing, additional measurements of microbial function, and a larger sample size will help to test the broader applicability of these findings and the role of synbiotics in the recovery of the human gut microbiome following exposure to stressors.
https://journals.asm.org/doi/epub/10.1128/aem.01880-22
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