Member Info for Marcbought

Have you got nothing at all to say about the company? Kind of says it all doesn't it? As I said, there is not a single thing to latch on to to be positive here over the next year. If you want to continue to stick your head in the sand, It doesn't really affect me, but I'm sure there are more wise people than you around.

75% down since may last year, I did say at the time if any company was interested in their one asset it would be long gone already, how can anyone be expecting an incredible result when there has been no offers made at all in this many years!!

I think this will likely drift down to the cash position, which I presume is under 9 million now so almost exactly half the current market cap, then you have the standard "aim discount" on top, and then you have the very real possibility of a raise And the pretty much open admission that nothing will happen for the next year so zero chance to sell out on a spike. I just feel sorry for those that bought into Cathals hype, but he was a used car salesman in his past, right? That said, I also think a lot of people need to take a long hard look at themselves, investing large chunks in an aim company with zero revenue Is just about the most stupid any strategy on the British stock markets, it is just pure greed to have pumped cash into a company like this when there are profit making companies with significant history valued poorly elsewhere. I guess it is a lesson learnt for a lot of people

Why would I hold this rubbish? I didn't realise it needed confirmation

Lol ok good luck holding share on Aim in a company with no news flow for a year and a potential raise. Recipe for disaster!

No news in years

No news due for months (or maybe years?)

No guarantee any trials are sucessful

No sympathy for shareholders from Cathal

A full and expensive board put in place by Cathal, now twidling their thumbs(?)

Wheres the reason to hold?

Funny the number of people on the various forums saying they are "topping up first thing" then total buys an hour into the day are £320 and sells are higher

Geordie Chris "next step is to raise the £4m or so"

Also Geordie Chris "who mentioned a raise?"

Why on earth shouldn't people moan?! He's been nothing but poison for years now and achieved absolutely nothing positive.

Why on earth would you top up if you think a raise is coming anyway? You just wait then get them at the raise price, or less as is normally the case on aim.

Utter nonsense! Like you say, either it was a great deal I'm which case why are you trying to blag it wasn't, or it was a terrible deal which they were very happy to walk us down the path of utter hookipa rug pulled them! How much contempt does he have for PIs?! He's doing it more and more these days. He's self infatuated, self righteous and clearly thinks private investors are collectively stupid

May as well have said go away and come back in December, nothing good to happen before then, I thought it was terrible and Cathal was inconsiderate too bulshy. It's funny how he shouts it from the rooftops when HVO went up andy percent but says bugger all when poolbeg is down over 60% from IPO, a failed deal with no backup plan, a hastily botched together presentation all he does is rude comments about holders, he's lost the plot and lost his supporters.

I can see this drifting to even half the price to match the current cash position and then what price does the inevitable raise come in?!

Usual hype nonsense from the team, scrambling around given the late cancellation

This was posted back in September, I wonder if anyone listened? Cathal has no backup plan here and is going for his usual (disgusting) approach of total silence when things don't work out. What an absolute charlatan he's turning out to be - he's not the messiah, hes just a very bad boy.

Raise incoming to pay for development of POLB001 in house or Cathal just fold and retire?

Why do you want a sell off Alamo?

I don't hold, but what a deal. The stuff dreams are made of on micro caps.

That's a big vote of confidence and very reassuring to see octopus up Thier stake again! This should calm a lot of nerves and be the start of a nice reversal today

Yes there's a big arbitrage opportunity here already

It should steady at about 4.6p

If you don't understand the difference between revenue and profit ...then your name is probably stt1

Results

All doses of POLB 001 significantly reduced clinically observed CRS scores. POLB 001 treatment showed statistically significant reductions in IL-6 (at high-dose), IL-4 (low- and high-dose), IL-8 (all doses) and MIP-1α (all doses) and a trend of reduced cytokine production in all other cytokines tested (IFN-γ, TNF, IL-10, IL-2). Adalimumab and POLB 001 effectively prevented CRS symptoms, however POLB 001 produced superior cytokine inhibition (ns). While adalimumab also significantly reduced IFN-γ, TNF, IL-6, and MIP-1α, some cytokines were elevated, including IL-10, IL-4, and IL-2 and there was no significant effect on IL-8. These results indicate that POLB 001 may be effective in preventing CRS. Both test articles were well tolerated.

Conclusion

In a model of anti-CD28 induced CRS, POLB 001 was shown to dose dependently reduce clinical CRS scores. POLB 001 significantly reduced peak serum levels of IL-4, IL-6, IL-8 and MIP1-α; all other cytokines tested, including IFN-γ, TNF, IL-10 and IL-2, showed trends of reduced peak serum levels. In combination with a previous successful trial in healthy human volunteers, the results of this animal study further support development of POLB 001 in a Phase 2 clinical study as a prophylactic for the prevention of immunotherapy-induced CRS.

They tested POLB 001 against Adalimumab and POLB 001 significantly reduced clinical CRS scores and peak serum levels of several key inflammatory cytokines (IL-4, IL-6, IL-8, and MIP1-α) and also showed a trend in reducing other cytokines. While adalimumab also reduced some cytokines, it elevated others, suggesting a less targeted effect.