Member Info for Let-It-Roll

£24 is possible imo

Let's just take a moment, just a very small one, to remember those poor, poor shorters. PMSL :-)

So excited! Typed the title as 33rd lol

No AML cells detectable!

 

17 September 2025

 

Hemogenyx Pharmaceuticals plc

 

("Hemogenyx Pharmaceuticals" or the "Company")

 

Third Patient Treated with HG-CT-1 CAR-T Therapy Successfully Passes Initial Safety Evaluation

 

Hemogenyx Pharmaceuticals plc is pleased to announce that the third patient has been successfully treated in the ongoing Phase I clinical trial of HG-CT-1, the Company's proprietary Chimeric Antigen Receptor T-cell (CAR-T) therapy for relapsed/refractory acute myeloid leukemia (R/R AML) in adults.

The treatment was well tolerated and met the trial's predefined initial safety criteria. Importantly, early indications of clinical efficacy have been observed. Preliminary assessment shows that original AML cells were not detectable in the patient using standard testing methods. The patient will continue to be monitored in line with the FDA-approved trial protocol to evaluate the achievement of the study's secondary endpoints described below.

Safety data from the first three patients treated at the lowest dose of HG-CT-1 will be submitted to an independent Data Safety Monitoring Board (DSMB) for review. The DSMB will determine whether dose escalation to the next level may proceed.

The Phase I trial is a dose-escalation study designed to evaluate the safety and tolerability of HG-CT-1. In addition to safety, the trial includes several key secondary endpoints:

·      Assessing the efficacy of HG-CT-1 based on AML-specific response criteria

·      Evaluating overall survival

·      Measuring progression-free survival

·      Determining duration of response in patients demonstrating clinical benefit

Data related to these secondary endpoints, including efficacy, durability, and overall clinical outcomes, will be collected over time through continued follow-up of the treated patient. These secondary endpoints are critical for assessing the potential clinical impact of HG-CT-1 in a patient population with limited remaining treatment options.

Further updates will be provided as the trial progresses.

Dr Vladislav Sandler, CEO & Co-Founder of Hemogenyx Pharmaceuticals, commented:

"The successful treatment of the third patient marks another important milestone for Hemogenyx Pharmaceuticals and for patients battling relapsed or refractory AML. We are encouraged by the favorable safety profile observed to date, together with the early signals of efficacy. These results reinforce the promise of HG-CT-1 as a potential new therapy for one of the most aggressive and intractable forms of leukemia. We remain committed to advancing the clinical development of this therapy to address a critical unmet medical need, while also creating long-term value for our shareholders."

Market Abuse Regulation (MAR) Disclosure

Certain information contained in this announcement would have been inside information for the purposes of Article 7 of Regulation No 596/2014

Consdoms: They popped up after hours.

Yes they are all buys i think looking at the sp at the time... not your average private investor like us, me thinks!

The last hour today was pure manipulation of the share price imo.

Roll on 7am tomorrow.

This poor chap!!

16:28:23 1,188.24 1,685 20.02k O

No way that's your average little PI like us.

10:56:42 1,445.1025 4,000 57.80k O

10:26:40 1,440.033 5,000 72.00k O

10:26:00 1,470.032 5,000 73.50k O

10:19:45 1,543.8608 6,122 94.52k O

08:05:01 1,424.21 3,000 42.73k O

08:00:33 1,401.188 3,550 49.74k O

11:06:21 1,396.182 5,000 69.81k O

13:36:29 1,407.40 4,400 61.93k O

Agree Tilly. Collusion at its worst. Disgusting.

My thoughts exactly. They probably know one has been lodged?

Must be stevey under a new monicker

If you don't know Tiger, are you for real?

Seeing some bigger buys coming through on L2 now.. £12k £10k etc.

plenty of shenanigans going on by the MM's. They are definitely holding this down atm

Think we might be about to pop again upwards

Yes... i think you'll find it means you've been banned from trading Hemo for the day. Because you are asking for too many quotes.

It happened to me about 4 weeks ago. I was banned for a whole day! B*stards!

Good news and £20

£20 is another phycological 'barrier' just as £10 was. Get through that, and we're heading for £24 which is where we really should be imo

We can see what they're up to on L2.

Lots of 1 share automated trades. lol.

Both of you lads behave. Now is not the time or place. Just sit back, drink tea, and enjoy the ride.

Reckon so

think old stevey got himself banned

4th on the LSE risers list