Member Info for Lakshmi888

WM - Me? Going where?

WM :) You mean Games.......

No doubt you'e missed ET, Goonies & Breakfast Club on yr list of faves;)

This is really beginning to do my head in, not knowing - do ya, don't ya, guess/ no guess/ guess.......! Cryptic........

Trill In which case. don't forget Shawshank, Godfather...

Ahhhhh! So it is guesses. Ha. Gochya! Nor will I........:P

As medicinal as vino is.........

Yup WM. A very, very large one.

Trill - funny! Was gonna go along the romcom lines but then thought better of it.........better try to stay in good(ish) books for longer than 24 hrs!! ;) lol

Thin Red LIne or Days of Heaven Deadhead Miles Badlands And if I got even one right Bonks, I darn well want more than one itsy, witsy, bitsy, poxy gold star, that's for sure ;)

If you leave CHK1 out for the moment, firstly think of it like this: Mutated DNA is damaged DNA. The genetic code has been altered whatever the cause may be i.e. genetic, chemical, environmental etc. These cells are thus cancerous by definition. They CAN undergo mitosis i.e. cell division. However as they tend to multipy at a much more rapid rate than normal cells undergoing 'uncontrolled abnormal mitosis', this thus results in proliferation of the disease. DNA damage induces activation of Chk1, which then transduces the checkpoint signal and facilitates cell cycle arrest and DNA damage repair thus promoting tumour growth and possibly playing a role in anticancer therapy resistance. There are trials being conducted where they are investigating whether activating, rather than inhibiting, Chk1 in the absence of chemotherapy might represent an innovative approach to suppress tumour growth. ''These findings suggest unique regulation of Chk1 in cell biology and cancer etiology, pointing to novel strategies for targeting Chk1 in cancer therapy.''

Hey Trill. Hpe you're well. Pls don't mention trading! :((

Well I'm keeping schtum ofr now & will assume (hope!) it's just luck/guesses on yr part unless proven otherwise......:)

:)) I'm trying to convince myself you're guessing re ething so delib. feigning ignorance BUT............... How, though?? Smart a*** as I said......you & cple of others..:) Or are yous?;)

Re.??? :) ha......

:P

'Present'. Working out how you know....

Matty-You shd have as long as nothing was sold. GL-you;ve nothing to lose....:)

WM-Yup You were. Though decent enough not to respond at the time:) Thought so:)

Matt, It's what they do now that matters:) http://www.lse.co.uk/share-regulatory-news.asp?shareprice=VER&share=vernalis