Member Info for krull

The EpiSwitch® platform has reduced to practice all stages of the discovery, development, validation, and monitoring of blood-based biomarkers, based on 3D genome architecture. To date, 3D genomic EpiSwitch® biomarkers, also known as chromosome conformation signatures; have been used in blood test format to stratify melanoma patients; prognostically stratify patients with fast versus slow progressing motor neurone disease; stratify patients with symptomatic and pre-symptomatic neurodegenerative disease; diagnose patients with thyroid cancer and various stages of prostate cancer; prognostically stratify patients for outcome in diffuse large B cell lymphoma; predictively stratify patients with NSCLC for response to the anti-PD-L1 ICI Avelumab; prognostically stratify high-risk individuals with an immune-health profile susceptible to systemic hyperreaction and severe COVID disease complications upon infection with SARS-CoV-2; and significantly increase PSA positive predictive value in the context of prostate cancer treatment in the population at risk

Yes a good read, in depth info on EpiSwitch CiRT test, the more feedback from CiRT the better it will get.

Cyberbud, That's a silly question to ask me! I don't know what other people are thinking, I can only speculate, maybe they don't understand the technology, maybe they are shorting the stock, maybe they want a better entry price, maybe they they don't want a challenge to the PSA test, Who the F.. knows, try contacting OBD and asking them for an explanation.

My understanding why a smaller number only needed in the trial. Many years of research have gone into finding rouge DNA that is the cause of PC. Thousands of blood samples have been taken from unfortunate souls that have suffered PC, they now know pretty much what to look for. The EpiSwitch technology looks at the DNA in 3D, this gives much better detail, making it easier to spot the offending DNA.

OBD has got a history bank of over 15,000 blood samples stored, using their EpiSwitch technology for use in all their product developments

Took a few more after hearing more good news on the way!

He was saying energy parity with a standard battery, the big question is: how much lighter will it be? How fast will it charge?

More good news before Christmas! That could be interesting.

Sorry wrong link in last post, Don't know that happened!

https://www.youtube.com/watch?v=sumCUzZp5yo&t=188s&pp=ygUFaWxpa2E%3D

https://www.youtube.com/watch?v=mCWc9pI89fk&pp=ygUFaWxpa2E%3D

One on youtube as well

https://www.youtube.com/watch?v=c0vpqsczZ-c

Yes Barno, too true.

ilika M-cap is tiny compared to the Goliath sized company's developing solid state, they will be circling/sniffing around tiny ilika for sure, wondering if the tec is better than theirs, or could the IP added to their own battery tec, making a better product! Then you have the Chinese, they would love to have this technology for themselves.

Is this for real! I find this statement unprofessional to the point of damning from a secretary or someone who reply's to emails. " we now need to see this tested in far greater numbers of men before we can determine just how effective this approach could be" I thought the idea of the trial was to test on a large number of men to determine what worked best!

Best for you not to invest here then dsc1978

That's a good name!

Development is now complete, that's a big achievement, we now have a big solid state battery developed in the UK

The title is misleading, we don't know ether way, PSE could well be included in the trial, we won't know for sure until it's closed.

Wireless charging, yes another new innovation for medical battery implants, should think though, the technology would be available for all manufacturers to make the most of, smart phones have been using it for a long time. I have noticed though, the battery and charger need to be quite close together for it to work, as they do with s- phones, with a car battery and wireless charging, the car wheels are going to elevate the battery, making the deign for a charger more challenging, then you have to look a the time it takes to charge, it will take longer, something you don't want if stopping for a charge on a longish journey

Cancer Research could end up looking very foolish if the new PSE test is not included, could say a big opportunity wasted, spending time and money gathering data on outdated technology would be mistake IMO.

The PSE test is designed to run alongside a standard PSA test, and combines the PSA score with five proprietary epigenetic biomarkers to predict, with 94% accuracy, the presence (or absence) of prostate cancer.2 Those with a PSE result of low likelihood of cancer can be placed on active surveillance and retested later without being referred for an invasive and often destructive biopsy. A high likelihood result would necessitate referral to a Urologist for further investigation. As well as very high accuracy, PSE has high specificity of 97% (PSA: 53%) and sensitivity of 86% (PSA: 64%), along with both high positive, 93% (PSA: 25%), and high negative, 95% (PSA: 86%), predictive values to assess the risk of prostate cancer in men.2 It has been validated as a laboratory developed test (LDT) in OBD's CLIA-certified testing laboratory in Frederick, Maryland.

The validation from a smaller participation group in the PSE trial was accepted and explained, it is something I don't fully understand, but I did reason it to do with the 3D EpiSwitch technology and Ai looking at 15,000 blood samples

Dug, it's a blood test! not medication, PSE is an option, folk can take all 3 tests if they want, also followed up by MRi scan and a biopsy. The USA is where our bread will be buttered, 25 million PSA tests are performed annually, If OBD manage to obtain 5 million of those at £750 a go, that is huge. The NHS will bulk at the £750 price. This this new trial where OBD might or might not be included, the data won't be available for a few years, we need to ramp up sales in the US now, in doing so, will will be saving lives

There is a comment section at the end of the article, could members add a comment about OBD new test, every little helps

Look at page 7 on the right hand side, looks like bowel C test is next, but could be any of them

https://d1io3yog0oux5.cloudfront.net/_66d99434f5d947b6e249f4f37530f91d/oxfordbiodynamics/db/2553/24445/pdf/OxfordBioDynamicsCompanyPresentationOctober2023_16113084796.pdf