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I’ll leave it to you Richard. I can see you’re very knowledgable. I’ve got more important things to do. Not sure why you always post negatively to people all the time. I’ve said Avacta looks very promising, I’ve offered advice and answered questions sensibly to those serious about Avacta. I’ll leave it in your hands to answer questions to those who might need advice on anything you might be knowledgeable about, like err……. Vapes, scratch cards or maybe Kebabs. Enjoy your weekend. Come Monday it’s back to security at Aldi for you. GLA others.
Yea. I thought. A big D1ck
Work in Clinical Trials. 20 plus years. Investing in PE. Over 30 years. CJ
Yea Richar. Is that short for Ruchard or D1ck ?
Yes I would say phase 2 for cancer and phase 3 for other conditions Sushi. But I would normally only look at studies from phase 2 as phase1 is normally a safety test. It is the next stage from giving the IMP to monkeys.
Sushi. TBH you could say every phase is pivotal depending on the study . Phase 1 is pivotal from pre-clinical as it is the first test on human subjects. Phase 2 because it is a bigger study with often a comparator. Phase 3 because it is compared to current treatments. Cancer studies are normally one step ahead as they are tested on subjects with cancer, whereas other studies phase 1 is only given to fit and healthy people without the condition.
Lol. Like I’ve already said
In cancer studies you have the benefit of seeing results in phase 1 as they are given to patients with the condition.
In almost all other CT studies the IMP is given to healthy volunteers who DO NOT have the condition. There you obviously don’t get any idea if it works at all - only that it is safe - Pre-clinical it is tested on monkeys, beagles, rabbits Phase 1 it is tested on humans.
Michbens. What is your opinion on the progress of Avacta ?
They are currently advertising for clinical phase 1 study for patients with MD. To qualify you need to be under 50 and healthy and not have MD. it is for testing as I said previously. Phase 2 will be given to patients with MD.
Phase I studies may involve risks even though an investigational drug has passed the Preclinical phase of testing. Phase I studies typically offer little or no benefit to the volunteer subjects; therefore they typically are compensated for their time and effort. Although usually conducted with healthy volunteers, Phase I trials are sometimes conducted with severely or terminally ill patients, for example those with AIDS or cancer.
That’s in non-cancer studies. Phase 1 is generally given to healthy subjects in clinical trials
LOL. You say you’ve waited long enough for this. This is only a very tiny amount of the study. I think it looks very promising, Though from what I’m seeing in trials these days is a movement towards ATMP. The results from what I’ve seen in those studies are amazing, totally life changing. Though cost is on another level. £millions per patient.
I’ve explained in plain English. I’ll do an explanation just for you
IT IS DOING OK
Yes. Did you know ???
Sushi. Phase 2 is always the pivotal stage. Cancer trials are different to other trials in that they will give the actual drug to subjects with cancer in Phase 1 - due to the obvious nature of the drug being given - destroying good cells along with the cancer cells, not many people would obviously volunteer for that study even with large payments
Most other conditions like MND and MS, their trials at phase 1 as well as most other phase 1 trials are given to perfectly healthy people without the condition. This is because phase 1 in trials is to get the data for safety, side effects , the pharmacokinetics of the IMP. This is usually the only phase which pays the subjects - phase 2 onwards is where the real data is collected, which would be where the subjects have the actual condition they are investigating. Phase 1 would normally decide if it’s suitable to give to subjects with the condition. The benefit of cancer phase 1 is that the IMP is given to people with the condition and therefore you can get to see results before Phase 2 which is the pivotal phase in any study. Phase 1 has the highest success rate in any studies then it decreases dramatically through other phases. Sushi there are obviously many other companies at this stage and further along the pipeline than AVCT. I’m working on over 150 studies right now and busy setting up a handful of new studies - stage 2 onwards as I work in a hospital research unit not a test centre for paid volunteers. I did think you worked in trials with your interest in this. Before you ask I don’t always have inside information on trials as I am often blinded to the study and those I am unblinded to, well it would not be right to use information to my benefit.
Sushi. I’ve worked in Trials for many years , from set-up through close-out and everything between. What area of trials do you work, preclinical ?
A good read and will help give a near layperson explanation. The drug Doxorubicin aka Red Devil has been around longer than me ( more than 50 years ) and it destroys cancer cells better than any, though the side effects are extreme. If Avacta can harness Doxorubicin and target just the cancer cells then Avacta could be many multiples of this - very early days yet. It has many years before the end of the trial and the failure rates are huge. I see it as a good punt for pre-result spikes in the share price and those brave enough to hang on, the possibility of success a few years down the line.
I think that was the only way they could raise any cash Mat. They have such a tiny mcap now, it would be nearly impossible to raise anything. Probably just a matter of time before it’s delisted and ends back in the major shareholders hands, the small investors losing out. It’s another of Jim’s. ‘Interests’.
2023 Ed’s basic was £160k and Alfredo’s £100k. Not huge for city wages, though ridiculous considering this is a part time job. A few hours a week position. They both have many positions and even at best could hardly give a day per week here. It took Ed many years to buy any shares and even then I think it was done as a gesture of sorts. More than likely given an option of buying around a years worth of salary in shares or go to performance related wages, more than likely pressured into buying them.
I’ve recently had a handful of investments written off in private equity, though with the tax relief this can bring the loss to a very small %. I really would recommend people to look into it. SEIS investments allow you to claim back 50% of your investment immediately following your investment - This gives you an immediate gain of 100% on your investment and if written off up to 45% of the loss can be reclaimed. I’ve had around 1 in 8 written off, though I’ve just had one increase 10 fold in less than 4 years and a couple increase around 4 fold in 3 or so years. What I’m getting at is, with decent management, you’d expect at least a few multibaggers in the portfolio over the years. Many of the pitches I look at are only interesting to the professionals if they look like they can give a return of 5 fold in 3 years or 10 fold in 5 years. Where are the big returns here?