RE: has a video5 Jun 2018 10:55
This research has promise for many malignancies,� said Cleveland Clinic medical oncologist Megan Kruse. �We rarely see such deep and durable responses with conventional therapies and we have not seen such dramatic responses with other immunotherapies in breast cancer to date.�
But, she cautioned that the time and labor to do such individualized treatments will create �a potential limitation of the approach.�
In addition to breast cancer, Dr. Rosenberg has seen regressions in patients with several other types of cancers including bile duct, colon, and cervical cancer.
Ms. Perkins arrived at the cancer institute, part of the National Institutes of Health in Bethesda, Md., after multiple chemotherapy and hormonal treatments had failed to stop her cancer from progressing.
Cancer institute scientists studied her tumors and identified 62 different mutations in the tumor cells. They then tested her immune cells to evaluate which ones recognized her mutations, then multiplied the immune cells billions of times over and infused them back into her. Her cancer now hasn�t returned, 22 months after treatment.
She also received the cancer drug Keytruda, or pembrolizumab, which researchers said was administered to prevent possible inactivation of the infused immune cells.
So you have to look at the costs of not only building a personal vaccine but adding a PD1 as well ....
Moditope TCR will not need PD1.