TCR ,,, some thoughts20 Aug 2019 11:40
TCR is under NDA ... not sure how they can update without releasing data of the science they are developing.
had been thinking about this .. naive CD4 T cell from a patient is given the TCR from a moditope reactive CD4 T cell .. but the difference is our moditope cd4 has already "differentiated" into a Cd4 killer .. is this differential carried over by the TCR ? or does the T cell need to have a further "sniff" at the vaccine to activate
because IMHO that may be an area of challenge
The CD4+T cells carry out multiple functions, ranging from activation of the cells of the innate immune system, B-lymphocytes, cytotoxic T cells, as well as nonimmune cells, and also play critical role in the suppression of immune reaction. Continuing studies identified new subsets of CD4+ cells besides the classical T-helper 1 (Th1) and T-helper 2 (Th2) cells. These include T-helper 17 (Th17), follicular helper T cell (Tfh), induced T-regulatory cells (iTreg), and the regulatory type 1 cells (Tr1) as well as the potentially distinct T-helper 9 (Th9). The differentiation of the different lineages depends on the complex network of specific cytokine signaling and transcription factors followed by epigenetic modifications. This paper will be focusing on the cytokine milieu and lineage specific transcription factors required for the differential development of the antigen-activated CD4+T cells, and also will cover a brief overview of the development pathway of mature naïve CD4+T cells, and finally the effector functions of each subtype will be summarized.
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