Member Info for inanaco

7.15 correct

Knowlesi

The share has hardly moved ... how can you prove that this tiny movement was not natural variation ....

its a neutral RNS .... plus points and negatives ... clearly the Avidmab in the short term and Biontech are potentially the driving force until the summer or FDA acceptance

SCIB2 is out of our hands .. what we do know CRUK are happy and running with it

after all they have NOT handed it back

further Tax Credits to come C7 ..

ivy many of these processes are about tolerance + or - of expectation when up scaling production ... its the amount of error in that supply that dictates acceptance ..

which is why Scancell worded

""with high yields and purity levels achieved"" now that might be 99.999 % ...

at 99.9% is failure ..

we don't know ...

but this is correct

""""When you are cutting edge you have no benchmarks to govern progress and timelines."""

which is the point i keep making ..

nobody else has anything to compare with it .. who else has Cytotoxic cd4 ?

is that why you stayed in VAL Ruck because the science posts presented by Bermuda and myself are irrelevant ...

well done ...

who is Gloating ...

you are telling us your an investment guru ... yet your holding a share that could tank to 4p on your prediction !!!!

at least Ivy has Sold down and declared it ...

your acting a bit like Tosh and Knowlesi holding while underwater and posting Dive Dive Dive ...

but in your case your next buy is not lower but higher !!!

you make no sense at all ..

"""Anyone who pretends they know the exact nature of the issue and solved by scaling up( ie process) is just guessing."""

they have already built Modi1 in the lab ... how do you think they have been able to test the TCR with BioNtech ?

if they did not have stable peptides to prime a t cell response in human blood

Ivy this is Not Guessing its factual read the science papers

Knowlesi ...

Scancell .. """""one that I am very much interested in because the risk reward is a once in lifetime"""

which is why i invest ... the science tells me !!!

Far out C7 ....... he missed

Knowlesi

Posted in: SCLP

Posts: 2,243

Price: 5.55

No Opinion

RE: Worst case scenario15 Mar 2019 14:19
Who said ive been selling ? My bazooka is primed - just feel we have further to go before I am comfortable loading up significantly. 6 months ish maybe...

Knowlesi

Posted in: SCLP

Posts: 2,243

Price: 5.60

No Opinion

RE: Worst case scenario15 Mar 2019 14:37
Element of pot kettle here me thinks...yep down quite considerably as Im sure you are...i am not trading this - averaging in - though havent added for about 2 years - waiting waiting because I believe we have further to go. If i had 100% of my net worth in - yeah might trade it - I don't, this is a speculative Long Term play - one that I am very much interested in because the risk reward is a once in lifetime

Ruck ... the fact that you have not sold ... and indeed "done nothing" in 2 years approx ... does not look good on your "investment CV" "adults in the room" posts in fact why are you even wasting your time "SP watching" ??? considering you understand all ?

at least i keep buying .. having made 2 more dips one at 5.4 and 7.2

""""The science may be “compelling” but the financials certainly aint!"""

in other words you have not taken up any opportunity in that period other than to try to explain that my £1000 buy at 3.9p was not as effective as your 10p buy ... (posting history)
anyway ... your VAL investment worked out well .. your history shows your unhappiness at .22 ... ps. its halved again

you should have listened to Bermuda and Myself at 7p ..

looks like you will have longer to wait then Knowlesi after all ... you are posting when underwater and posting Dive Dive Dive ...

while at the same time wishing to release a buy order ... is strange at the best of times ... your clearly are so convinced of the merit of holding because of a possible deal that you will not take the risk of being out .. while posting a complete "fictional" reason as to why Scancell has not included data in an interim that you would like to see ... its possible that the science side has moved to a "price" discussion ... just as easy as " not gone anywhere" ... in which case the "get the sp lower camp" would post any negative ....... when in reality you have no idea it just might mean Scancell are discussing a deal and cannot comment

but waiting to buy at "your target" is not the same as ... Sell ... because this is going nowhere ... your asking folks to believe you !! so that they will sell to facilitate ..

what ever ... you clearly class yourself as an expert ..

Your last buy in Scancell at 10p ..

and you said you bought VAL to make money

"adults in the room"

ATB

Now if you cannot understand from an investment point of view ...

that "Efficacy" relates to profitability ...

that a Single product that can be used in more than 4 major cancers

is more valuable than a dedicated single use vaccine ...

then you are in the wrong investment Ruck ...

The Costs of the trials far outweighs the cost of a few extra years research ...

thus the cost of dilution of a trial would be staggering if the results are poor because we rushed moditope into the clinic

So that extra time and investment at the start really does pay off in the future ...

Investors that understand that will buy in ... those that don't .. won't

Diggles gets it !!

enjoy your marmite

Scancell has embarked on a "Land Grab" of patents around SIPTM ......... why have they done that ?
1/ Lindy discovered Autophagy on Cancer

2/ lindy also discovered CD4 will differentiate into Killer CD4 and "WILL" go after these targets

cancer will fight back with suppression ...

Lindy then developed with ISA pharma this complex linked peptides with adjuvant giving us up to 100 X the potency of a classic peptide vaccine and at the same time polerizing the T cells to TH1 high inflammatory which mediates the effects of the cancers ability to suppress ... indeed the cancer is forced into more autophagy and its forced to display the MHC class 11 epitope that modi1 is targeting .. because of the interferon gamma cytokine delivered by the Modi1 T cell ...

Not content with that she looked at the work done on Hydrophobic peptides able to generate High affinity and immunogenicity on MHC class 1 ... ie CD8 .....

then applied that to CD4 .... and decided that Hydrophobic is the way to go ..........

the Result a delay ... the effects of which

The mouse will not die ...

even more jam tomorrow ..

if you cannot follow the posts and the rational behind them ..

best stick to what you can follow ..

Modi-1 conjugates - novel cutting-edge products
? Strong bias toward hydrophobic amino acids at T-cell receptor
contact residues within immunogenic epitopes (Chowell et al 2015)
? Hydrophobic peptides
? Challenging synthetic properties
? Manufacturing
? Analytical development

Significance
The design of effective T-cell vaccines against pathogens and tumor antigens is challenged by the highly inefficient identification of the subset of peptides from a given antigen that effectively stimulate an immune response. Here we report that the relative hydrophobicity of T-cell receptor contact residues is markedly enriched in immunogenic major histocompatibility complex class I epitopes in both human and murine MHCs, and in both self and pathogen-derived immunogenic epitopes. Incorporating hydrophobicity into T-cell epitope prediction models increases the efficiency of epitope identification, which will manifest in the time and cost of T-cell vaccine development. Amino acid hydrophobicity may represent a biochemical basis by which T cells discriminate immunogenic epitopes within the background of self peptides.

https://www.pnas.org/content/112/14/E1754

Edited by Ira Mellman, Genentech, Inc., South San Francisco, CA, and approved March 2, 2015 (received for review January 21, 2015)

being trying to find how complex the conjugates become

first we have the challenge of Modifying the epitope to become Moditope ie a modfied epitope

second scancell made it even more complex by switching to hydrophobic peptides because they bind better

third

what modification is need for this chemical ligand ... ? to bind to the adjuvant

taken from ISA papers "a modified"

"""we have previously shown that the novel TLR2-L Amplivant (AV), a modified Pam3CSK4, potentiates the maturation effects on murine DCs """

then if you research further ... it in itself is a field

Peptide and protein conjugates hold a prominent position in the area of bioconjugate chemistry. They have been the subject of intensive studies over the years, because of their high potential in, for example, the biomedical field. Furthermore, their functional richness and structural vulnerability makes efficient and selective conjugation of these biomolecules often a real endeavor. I have been involved in this highly active research field for a number of years already, and have seen it mature into an area where highly complex hybrid structures can be created. Still, with regard to both toolbox development and application of bioconjugation strategies much research is required.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355898/

strikes me we are building a vaccine that is so far ahead of its time ..

even the manufacturing industry is struggling to keep up ...

Claim to set loss from share disposal against income

You may be able to reduce your Income Tax liability using relief for allowable capital losses provided certain conditions are met. The allowable capital losses must have arisen on a disposal, other than a gift, of shares that you acquired by subscription in a qualifying trading company, or following a negligible value claim in respect of such shares.

EIS scheme is a qualifying share

other possible ways of transferring a capital loss onto income tax side ...

https://www.gov.uk/government/publications/negligible-value-claims-and-income-tax-losses-on-disposals-of-shares-you-have-subscribed-for-in-qualifying-trading-companies-hs286-self-assessment-he/hs286-negligible-value-claims-and-income-tax-losses-on-disposals-of-shares-you-have-subscribed-for-in-qualifying-trading-companies-2019

that would need an accountant to digest ... but again its an offset by the look of it ..

can you show a link or something ...

because if you have already claimed upfront tax relief ..

then your loss if you sell is on the capital gains side .. used against profit and as a carry over if you have not made a profit

so i dont understand what you are "claiming back" HMRC in effect are not paying you, you are just paying less tax ...