Very interesting read across from Sanofi’s $3.2bill acquisition of Translate Bio.
The company: Translate Bio adds an mRNA technology platform and strong capabilities to our research, further advancing our ability to explore the promise of this technology to develop both best-in-class vaccines and therapeutics,” said Paul Hudson, Sanofi Chief Executive Officer. “A fully owned platform allows us to develop additional opportunities in the fast-evolving mRNA space. We will also be able to accelerate our existing partnered programs already under development. Our goal is to unlock the potential of mRNA in other strategic areas such as immunology, oncology, and rare diseases in addition to vaccines.”
Exactly, look what is happening in the M&A in the sector, not to mention one of the hottest areas, Radiotherapy,Gene therapy we got our US partner, however LG and Daewoong both loaded up with cash and are both tied up with Avacta, are coming up in
The inside lane!
As I have mentioned before, we will be moving up a gear or three and as a backup plan,I would buy Autoliv ( ALV on NY ) the world’s largest manufacturer of automotive safety supplies incl. seatbelts, we will need them! Strap yourself in, we will have lift off soon! Nothing like a bit of humour in the morning.
Bispecific antibody projects development and M&A are gaining momentum, with Amgen yesterday continuing shopping, latest company is Teneobio for $900mill upfront + milestone payments valued up to $1.6 bill.Bispecific and multi specific antibody technologies is the name of the game.Only two months after Amgen buying Lumakras.
AVACTA with AVA6000 and a pipe line of other projects, will make the valuation keep going higher and off course we have Rapid Antigen LFT about to be loaded on trucks on it’s way to Heathrow for overseas destination.
Bring on next week !!
President Joe Biden is expected to announce later Thursday a plan to require all federal employees to either get vaccinated or be subjected to regular testing, social distancing, face-mask requirements and restricted travel as he continues to encourage more unvaccinated Americans to get their shots
The latest from Professors in India :
The scientists, however, insisted on a few conditions. Firstly, RAT should be of reasonable sensitivity, much higher proportion of people should be tested (around 0.5 per cent of population per day), those who undergone testes should be isolated till the results are available and testing should be accompanied with other non-pharmaceutical interventions such as wearing mask and keeping physical distancing, etc.
More tests during peak
“At the peak of the pandemic, we should be carrying out five times more (RAT) tests than what we are doing today. That is about 8 to 9 million tests per day. But when the cases come down, on an average, you can test less,” Menon told BusinessLine.
While RT-PCR tests are more sensitive than rapid antigen tests, they are more expensive and do not provide results immediately. Therefore, the precise mix of tests needed to optimise outcomes while accounting for cost constraints has been unclear.
During the Covid pandemic, different States in India have been using different mixes of RT-PCR and RAT. The increasing reliance on lesser-sensitive RAT – as they are much cheaper than RT-PCR -- by many States was a bone of a contention between them and the Union Health Ministry.
Their analysis suggested that use of only rapid antigen tests could achieve similar outcomes, in terms identification of total infections, as using only RT-PCR tests -- as long as the number of people tested is high enough. This suggests that governments in lower and middle-income countries might be able to achieve optimal outcomes by concentrating on ramping up testing using less sensitive tests which provide immediate results, rather than favouring RT-PCR.
The authors suggested that governments should continue to explore different mixes of tests. . Given that the costs of testing are falling, this mix could also be recalibrated regularly to monitor what makes the most economic sense.
“Tests are continually improving, and the trade-offs are in favour of rapid testing, even if it is less sensitive,” Menon said. “Modeling the effects of using different combinations of tests, keeping in mind their relative costs, can suggest specific policy changes that will have a substantial effect on changing the trajectory of the epidemic.”
US slowly moving back into “ pseudo lockdown” with only a handful of states in control.
“ In addition to revising its mask guidance on Tuesday, the Centers for Disease Control and Prevention also quietly updated its testing recommendations for people who are fully vaccinated against the coronavirus.
The agency now advises that vaccinated people be tested for the virus if they come into contact with someone with Covid-19, even if they have no symptoms. Previously, the health agency had said that fully vaccinated people did not need to be tested after exposure to the virus unless they were experiencing symptoms.”
“Our updated guidance recommends vaccinated people get tested upon exposure regardless of symptoms,” Dr. Rochelle P. Walensky, the agency’s director, said in an email to The New York Times. “Testing is widely available.”
The virus is out of control in the US, Asia and Australia.
All screaming for daily tests.
Biden?s ?Summer of Joy? Turns Grim as Delta Infections Skyrocket https://www.bloomberg.com/news/articles/2021-07-28/biden-s-summer-of-joy-turns-grim-as-delta-infections-skyrocket
This all I Had at the moment
Pfizer, AstraZeneca vaccine antibody may wane after 2-3 months: Lancet study
The researchers from University College London (UCL) in the UK noted that if the antibody levels carry on dropping at this rate, there are concerns that the protective effects of the vaccines may also begin to wear off, particularly against new variants
For Pfizer, antibody levels reduced from a median of 7506 Units per millilitre (U/mL) at 2141 days, to 3320 U/mL at 70 or more days
For Pfizer, antibody levels reduced from a median of 7506 Units per millilitre (U/mL) at 2141 days, to 3320 U/mL at 70 or more days
Jul 27, 2021,
Updated Jul 27, 2021, 1:23 PM IST
Total antibody levels start to wane six weeks after complete immunisation with Pfizer and AstraZeneca vaccines, and can reduce by more than 50 per cent over 10 weeks, according to study published in The Lancet journal.
The researchers from University College London (UCL) in the UK noted that if the antibody levels carry on dropping at this rate, there are concerns that the protective effects of the vaccines may also begin to wear off, particularly against new variants.
However, they said, how soon that might happen cannot be predicted yet. The UCL Virus Watch study also found that antibody levels are substantially higher following two doses of the Pfizer vaccine than after two shots of the AstraZeneca preventive, known as Covishield in India.
Antibody levels were also much higher in vaccinated people than those with prior SARS-CoV-2 infection, they said. "The levels of antibody following both doses of either the AstraZeneca or Pfizer vaccine were initially very high, which is likely to be an important part of why they are so protective against severe COVID-19," said Madhumita Shrotri from UCL Institute of Health Informatics.
"However, we found these levels dropped substantially over the course of two to three months," Shrotri said in a statement. The findings based on data from over 600 people aged 18 and above were consistent across all groups of people regardless of age, chronic illnesses or sex, according to the researchers.
The authors highlight that although the clinical implications of waning antibody levels are not yet clear, some decline was expected and current research shows that vaccines remain effective against severe disease. For Pfizer, antibody levels reduced from a median of 7506 Units per millilitre (U/mL) at 2141 days, to 3320 U/mL at 70 or more days.
For AstraZeneca vaccine, antibody levels reduced from a median of 1201 U/mL at 020 days to 190 U/mL at 70 or more days, over five-fold reduction. "When we are thinking about who should be prioritised for booster doses our data suggests that those vaccinated earliest, particularly with the AstraZeneca vaccine, are likely to now have the lowest antibody levels," said Professor Rob Aldridge from UCL Institute of Health Informatics.
Just out from The Lancet:
Pfizer, Astra vaccine antibody levels may decline after 2-3 months: Lancet
Total antibody levels start to wane six weeks after complete immunisation with Pfizer and AstraZeneca vaccines, and can reduce by more than 50 per cent over 10 weeks, according to The Lancet journal
The conclusion is we need daily rapid antigen test to monitor risk groups.
Anthony Fauci, the White House chief medical adviser, said on Sunday top US health officials were discussing whether to revise mask guidance for Americans vaccinated against Covid-19.
Matt Robinson and Bobby Bluford put on PPE before entering the Covid isolation unit at Methodist University hospital in Memphis.
‘Heart-wrenching’: inside a hospital grappling with Delta and vaccine hesitancy
“This is under active consideration,” Fauci told CNN’s State of the Union, though he also emphasized that local governments can issue their own rules under current guidance from the Centers for Disease Control and Prevention (CDC).
Los Angeles county and St Louis, Missouri, have reinstated indoor mask requirements and other cities are weighing whether to do the same.
After a significant drop in Covid-19 cases because of the national vaccine campaign, infections are rising in all 50 states and Washington DC. The increases are highest in states with large groups of unvaccinated people. More than 610,000 have died from Covid-19 in the US.
At a White House on Thursday the surgeon general, Vivek Murthy, said 97% of hospital admissions and 99.5% of Covid deaths were occurring among unvaccinated people.
More than 162.7 million Americans are vaccinated – or 49% of the population, according to the CDC.
Fauci said local leaders, particularly in areas with low rates of vaccination, needed to lead outreach efforts to get people vaccinated.
He highlighted recent work by two prominent Republicans who have repeatedly criticized him: a Louisiana representative, Steve Scalise, and the governor of Florida, Ron DeSantis.
“??I was very heartened to hear people like Steve Scalise come out and say, ‘Hey, we’ve got to get vaccinated,’” Fauci said. “Even Governor DeSantis right now in Florida is saying the same thing. We’ve got to get more people who relate well to the individuals who are not getting vaccinated to get out there and encourage them to get vaccinated.”
Among those reporting they definitely won’t get vaccinated, 23% are Republican, 16% are independent and 2% are Democrats, according to the Kaiser Family Foundation vaccine monitor.
First lady Jill Biden comforts Adriana Lyttle, 12, as she receives her vaccine in Nashville, Tennessee in June.
Tennessee radio host doubted and mocked vaccines – now he has Covid
DeSantis sells merchandise which mocks masks and Fauci, but cases in Florida are the highest they have been since January.
“These vaccines are saving lives,” DeSantis said last week.
Scalise, the House Republican whip, was vaccinated last week and told the New Orleans Times-Picayune he had waited because he thought he had some immunity from an earlier Covid-19 infection. But the rise of the Delta variant appeared to sway him.
“When you talk to people who run hospitals, in New Orleans or other states, 90% of people in hospital with Delta variant have not been vaccinated,” he said. “That’s another signal t
Everybody have a good week end , suspect we could have an interesting next week.
Off for some Concept 2 rowing and cycling, followed by several glasses of White burgundy.
Let us see what Avacta is up to on the LFT front and indeed perhaps more news on AVA6000 in the US with the FDA trials.
With Novartis out there shopping in the Radiotherapy market, one could see all sorts of reason why AVCT’s SOP is far too low.
I believe we will have Avacta featuring more in the press and be seen working with the government.Today’s press on how efficient an efficient and reliable LFT would work at schools and universities and at corporate businesses( once OTC approved, which I suspect is any day ) and with overseas interest really kicking in, the monthly demand will easily exceed current max est of 60 mill a month and we could see new SOP etc.
US est for Test demand globally is 2- 2 1/2 bill !!!
Friday is always interesting, but with the Week end coming up, one would expect more news flow with regards to the use of Rapid daily antigen LFT and one that can identify the Delta Variant as well.
BUY AVACTA on a Friday and you seldom go wrong.
Workers could be tested for Covid every day to avoid them needing to self-isolate if they come into contact with someone infected with the virus, a top scientist claimed today.
England's 'pingdemic' chaos has led to warnings that supermarkets may be left with empty shelves and lead to the 'most serious' food shortages since WWII.
But Oxford University researchers say the rules could be replaced with daily swabs in workplaces.
Their trial revealed the scheme was just as effective at preventing outbreaks among children as sending home an entire 'bubble' for ten days whenever someone tested positive.
Professor Tim Peto, one of the experts behind the study, said the testing approach could be applied to workplace settings.
If No10 adopted the policy, it would allow millions to return to work and would stop industries from collapsing in the face of quarantine chaos. A record 1.3million self-isolation alerts were sent out across the country last week.