Rns8 Jan 2025 10:21
January 2025
Physiomics plc
("Physiomics" or the "Company")
Clinical Trial Approval
Physiomics plc (AIM: PYC), a leading mathematical modelling, data science and biostatistics company supporting the development of new therapeutics and personalised medicine solutions, is delighted to announce that the Innovate UK Funded project called PREDICT-ONC has now received both regulatory and ethical approval.
The Company's personalised dosing software has been developed primarily with grant funding from UK bodies, including £68,000 from Innovate UK (March 2018), £150,000 from the National Institute for Head and Care Research to fund the PARTNER study (March 2020) and more recently £137,376 from Innovate UK and The Office for Life Sciences to fund the PREDICT-ONC study (announced in November 2023).
The software was initially developed to support clinicians make cancer chemotherapy (docetaxel) dosing decisions, helping to optimise dosing for individual patients to improve patient outcomes. However, as a result of the PARTNER study (completed in January 2023), a second utility was observed, in that the software could be used to support the dosing of an expensive biological drug GCSF. This drug is routinely used in many countries to counteract the toxic effect chemotherapy has on patient's white blood cells - a condition known as neutropenia.
The aim of this latest Innovate UK funded grant, "Precision Risk Evaluation and G-CSF Dosing for Chemotherapy-Induced Neutropenia Tool", known as PREDICT-ONC ("Project"), is to further develop and evaluate the software's ability to predict GCSF dosing. The Project, being run in partnership with Beyond Blood Diagnostics Limited ("Beyond Blood Diagnostics") and Blackpool Teaching Hospitals NHS Foundation Trust ("Blackpool Teaching Hospitals") will recruit breast cancer patients undergoing standard of care GCSF treatment onto an observational clinical trial in order to predict and measure the effect treatment has on neutropenia. The data resulting from this trial will support the refinement and evaluation of the software.
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