Member Info for Fruitsnveg

Antofelli,

4 words:

And you believe Boris...?

"Synairgen is investigating the in vitro activity of SNG001 against the Delta and Omicron variants of SARS-CoV-2 and will make data available as soon as possible". From the last RNS.

HeleB, sorry to hear about your son. The video Alpha posted is a great resource. I've not done these as not had Covid, touch wood (but have used similar NHS physio breathing techniques for chronic cough, and with daily practice they are worthwhile and get results). I wish him a speedy recovery.

Thanks for clarifying Matml, that's how I hoped it would be.

Quasar,

"they started the therapeutic way way after Synairgen SNG001".

You tell blatant untruths.

The Merck drug has been in development for years.
The Pfizer drug wasn't started from zero either. During the SARS outbreak in 2003, Pfizer scientists had begun to search for ways to combat that coronavirus. They focussed on a viral protein called a protease. Their drug disrupts the protease, stopping the virus replicating.

Don't spin lies. Do some research instead.

Additionally, Pfizer has said it plans to produce at least 80 million more in 2022. To clarify, that's a few billion less doses than may be required globally. I think we're good.

Alpha, my understanding from trying to find out more on this earlier (Royal college of paediatrics website I think) is that severity apparently seeming lower (so far) in Omni is due to the virus replicating more in the bronchus (windpipe down) and causing less damage in the lungs than Delta for example, but it was pointed out that for those patients whose immune system doesn't respond well, they can still end up with it in the lungs and will therefore have more severe illness. My guess is that they will eventually present with breathlessness too. Perhaps a medical person here who knows more could advise...?

"Speaking to MPs on the Health and Social Care Select Committee, Professor Whitty said: 'If I project forward, I would anticipate in a number of years, possibly 18 months, possibly slightly less... we will have polyvalent vaccines which will cover a much wider range [of variants].

'And we will probably have several antivirals... and a variety of other countermeasures that mean that the great majority, and probably almost all of the heavy lifting, when we get a new variant, unless it is extremely different, can be met by medical means.' Prof. Whitty

This last para indicates th eneed for SNG001 and like drugs will last much longer than Q1 next year!

So says Whitty:

https://www.dailymail.co.uk/news/article-10313513/Prepare-18-MONTHS-Covid-chaos-says-Chris-Whitty.html

Thanks for posting Matml. What will that mean for ACTIV 2 P3 trial? I guess they will continue as is with the comparator? That *potentially* puts us in a better position than previously, right?

https://www.standard.co.uk/news/uk/children-risk-omicron-covid-variant-south-africa-b972091.html

They are being cautious, which IMO is the right approach. In the first Covid waves they were not prepared for Multisystem inflammatory syndrome in children, they do not want to get it wrong again.

Just a point on patients having more choice in their treatment and driving demand for orders. It's the physicians who decide the pathways and treatment protocols, not the patients. Patients are clueless about drug interactions, they would never be given a choice as to which treatment they would 'prefer' or want. Trial results will inform the experts, big pharma. They in turn will supply hospitals, care homes, governments, GPs, etc. Those who buy and stockpile or prescribe are our potential customers, not the public. That is also why it matters not a lot if SNG001 gets much mass media attention - it's industry attention that absolutely matters and we have that. The public will know of us soon enough if P3 gets us on shelves. Case in point: very few people walking down your average high street today could name a flu vaccine by actual name, yet many will rock up each year to their GP and ask for 'the flu vaccine'. That fact never impacted Sanofi's worldwide sales, or drove them, as far as I'm aware.

Love it theBoyg :-)

I wonder if the timing will clash with Bojo’s TV address? The numbers are pretty startling today.

Thanks, will do.

Oak et al, how do I get on to Reddit?

I didn't mean to name check her on here (sorry E) but yes I'm aware she's been a long time supporter.

Good work Aphageddon and well done Eileen Kent. Exciting.

Thanks Oak

definitely today Oak? Could it be later in the week?