RE: 9 trading days to June17 May 2020 19:45
Interferons (IFNs), as indicated by their name, interfere with viral infections (Pestka, 2007). The type I IFNs, comprising 12 different a subtypes, ß, e, ?, and ? IFNs, are ubiquitously induced by viral and bacterial infections but are predominantly produced by plasmacytoid dendritic cells (pDCs). They bind a common IFNa/ß (IFNAR) heterodimeric receptor, inducing hundreds of genes termed interferon-stimulated genes (ISGs) that mediate a wide array of biological functions, including both activating and inhibitory immunomodulatory effects (González-Navajas et al., 2012).