Member Info for Fadec92

Hi BlackHopper was running before Covid19, now the addition of a third mix tank to increase the POSP's overall capacity and the Improvements of the heating system for the sand drying and solvent recovery, there was also a few more that were tweeted!

Elir looking at the project i don’t think it’s opencast as in a pit mining but it is surface mining but with a difference it’s called an overburden and is a hog back as Americans call it the Mesaverde Group it pushes up through the surface too make a wall that is scooped out, so very cheap and easy too extract as it falls off for collection!

I welcome that Bridges but just have a look at yours is more too the point I’m trying too make!

Bridges you are just making up stuff, I haven’t been committing on the market and opposite of that, I’ve trying too normalize extreme posts, by adding what I believe is fact and providing the prove in links too challenge their view!

Asserting a value that has a multi billion pound valuation and talks of no risk of downside and talks it’s a given only a waiting game to success is dangerous and a lot of you have been doing it!

There’s lots of positives I get that but there’s also the negatives too which are always left out, and it ain’t the most sensible approach!

No problem PCS, what’s happened is an eye opener there is a lot too look forward too but I don’t think the sp is going too be as plain sailing as we have seen over the last 10 months, I think also there needs to be a reality check and a more realistic views compared with what I’ve seen over the course of the rise, remember there’s no experts here and definitely including me, just be careful that is the bottom line!

Here’s the period!

https://imgur.com/a/gXhvP9f

Ok Londonwolfie fair comment, it was in a not so good place at that point, if I can remember it was always trying too regain and struggling from the placing before the last one at 0.4p in July 2019!

I don’t know if I’m looking at the wrong chart, but if you look at the share price from 26th March 2020 RNS it was circa 0.25p it went on too break 1p with no other news!

“Sareum Signs Global Licensing Deal for its FLT3+Aurora Kinase Inhibitor Programme with a China-based Specialty Pharma Company“

The share price Quadrupled or 4 bag from that news!

The latest on the formulation issues in the AGM statement said that they have re-formulated the SDC molecule too reach the MTD not sure this has been achieved yet so this is still an on going concern!

RMM I don’t think the animal has to die too reach MTD, here’s a publication of Maximum Tolerated Dose preclinical dose determination. there are 5 ways :-

“There are typically five options for defining a dose: Maximum Tolerated Dose (MTD), Maximum Feasible Dose (MFD), limit dose (1000mg/kg), exposure saturation, and dose providing a 50-fold margin of exposure. The most common of these, the maximum tolerated dose, is defined as the highest dose of a drug that does not cause unacceptable side effects or overt toxicity in a specific period of time. These side effects can range from mild effects such as reduced weight gain, moderate effects such as weight loss up to 20% or substantial effects such as unresponsiveness.“

Here is the bit about the death not needed too reach MTD!

“Maximum tolerated dose studies are not designed to cause mortality, therefore death is not an appropriate end point.”

https://imgur.com/a/CKKdfsu

https://pacificbiolabs.com/maximum-tolerated-dose-mtd-an-effective-preclinical-dose-determination-strategy

Just had to research that word, and you are definitely entitled too saying that what you think, but I think its not a good place Aim it brings the worse out of people and as long as the market makers can find buyers will push it too extremes, it dosnt help that people read and invest off comments based on a site a lot of people refer too and say things are a given or extremely high valuation on the upside with no suggestions of downside, it’s cycle driven so maybe It can get back or revisit lows, but of late it’s been in a bull market, I think Robin Davidson’s pointed out it was the second biggest gaining European pharma share so being too heavy then there is scope for them too take it down on a big move on any negativity!

Not a pretty sight with the drop late on, It does open up the possibility that the same can happen with the Tyk2 molecules, they come from the same kinase library, and the MTD not being reached with SDC-1801 is the risk that is taken too, they have managed to patch over the inability to formulate the molecule for 20 months and has now changed, if you listen to every one here this is a done deal but I don’t think any of the negatives have been highlighted in any sort of way by anyone!

NI 51-101 and COGEH criteria, like in the PetroTeq regulatory news release!

https://petroteq.energy/operations/oil-sands-supply

Applicant has made the Arguments/Remarks and was review by K.Cheng and the decision was a Final Rejection Decision, if you follow the process of the other patent which had a final rejection the start of last year, then they will probably request an interview and a request for more time An Extension and a request for an interview with the examiner, maybe in a couple of months more info will be provided to support further progress!

https://imgur.com/a/MZcbdQy

Num4 it’s a different patent so I don’t think one effects the other!

Num4 this is the Patent from the notice of allowance RNS dated Oct 8th which we know about, the only other one pending that I know of in US has had a final rejection so that’s 16/343639.

https://imgur.com/a/v4KvaMw

Colin

“As a result, the Mine Safety and Health Administration ("MSHA") operating plan won't be released before 21 December 2020“

So the mining contractors should have the certificates, the reason for not starting straight away was too get Christmas and Newyear holidays out of the way so they planned full startup for first week back after new year, what’s the point of full start up then too release the staff on holiday, think about it!

Communication channel up and running!

Thoth yes that’s the one in October 2019, I remember you commented that you were pleased with the effect vs standard care!

No solid tumors have been targeted remember the poster presentation “Immunotherapeutic effects of the TYK2 inhibitor SAR-20351 in syngeneic tumor models“