A.I. Illumina parsortix Angle Plc.4 Aug 2025 14:30
ANGLE plc, a liquid biopsy company specializing in circulating tumor cells (CTCs), has been working with Illumina on a collaborative project involving ANGLE's Parsortix system
ANGLE's Parsortix system
The Parsortix system is a device that captures and harvests intact CTCs from blood samples, allowing for downstream analysis.
It is intended to enrich CTCs from patients diagnosed with metastatic breast cancer using microfluidic chambers.
The Parsortix PC1 system has received FDA clearance for its clinical use to guide precision cancer care.
Collaboration with Illumina
ANGLE and Illumina have collaborated on developing a workflow for the dual analysis of CTC-DNA and circulating tumor DNA (ctDNA) using Illumina's sequencing platform.
This approach combines the advantages of both CTC and ctDNA analysis, potentially providing a more comprehensive view of the patient's cancer profile.
A recent study using this workflow on lung cancer patients revealed actionable DNA variants present in CTC-DNA but not in ctDNA, highlighting the importance of analyzing intact cancer cells.
Illumina has dedicated a webinar to ANGLE's findings, marking a co-marketing initiative between the two companies.
This collaboration has the potential to allow Illumina customers to offer CTC analysis in the future by combining the Parsortix system with Illumina's NGS assays.
Broader context
Liquid biopsies are becoming increasingly important in cancer research and personalized medicine.
Analyzing CTCs provides valuable information on cancer cells themselves, including their genomic and proteomic profiles.
The ability to combine CTC and ctDNA analysis using platforms like Illumina's, along with technologies like ANGLE's Parsortix system, could significantly advance the field of liquid biopsy and its applications in guiding cancer diagnosis and treatment.