New England Journal of Medicine3 Dec 2020 05:47
Not new news but just a mention of Sng at the very bottom,shows they are aware of who we are and what we do
https://www.nejm.org/doi/10.1056/NEJMoa2023184
For interferon beta-1a, no other large trials exist. With 4000 patients, the rate ratio for death in the Solidarity trial was 1.16 (95% CI, 0.96 to 1.39), or 1.12 (95% CI, 0.83 to 1.51) without lopinavir co-administration; these findings suggest no mortality reduction. Subcutaneous and intravenous interferon have different pharmacokinetic characteristics,18,19 and glucocorticoids could affect interferon signaling,20,21 but the clinical relevance of both issues is unclear. Most interferon was administered subcutaneously, because intravenous interferon was used only in patients receiving high-flow oxygen or ventilation, and distribution of it began only in late May, just before strong evidence emerged of glucocorticoid efficacy in such patients.22,23 Hence, few patients received intravenous interferon without a glucocorticoid. Approximately half the patients who were assigned to interferon (and half their controls) received glucocorticoids, but the rate ratio for death with interferon as compared with its control seemed unaffected by glucocorticoid use. Randomization to interferon was discontinued on October 16, but other trials continue. A report that nebulized interferon beta-1a might be effective involved only approximately 100 patients with Covid-19 (ClinicalTrials.gov number, NCT04385095. opens in new tab), but the ongoing placebo-controlled ACTT-3 of subcutaneous interferon beta-1a aims to involve 1000 patients (NCT04492475. opens in new tab), with examination of time to recovery.
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