Proposed Directors of Tirupati Graphite explain why they have requisitioned an GM. Watch the video here.
Pasted the side effects twice but would certainly be an advantage if corticosteroids could be concentrated in the lungs and not the rest of the body.
https://www.mayoclinic.org/steroids/art-20045692
https://www.sciencedirect.com/science/article/pii/S0021925820407732#:~:text=Fibroblast%20activation%20protein%20(FAP)%20is,pulmonary%20fibrosis%20after%20lung%20injury.
'Idiopathic pulmonary fibrosis is a disease characterized by progressive, unrelenting lung scarring, with death from respiratory failure within 2–4 years unless lung transplantation is performed. New effective therapies are clearly needed. Fibroblast activation protein (FAP) is a cell surface-associated serine protease up-regulated in the lungs of patients with idiopathic pulmonary fibrosis'
I know a little about lung fibrosis (idiopathic pulmonary fibrosis) from family experience, & you get FAP in the affected lungs:
'Fibroblast activation protein (FAP) is a cell surface-associated serine protease up-regulated in the lungs of patients with idiopathic pulmonary fibrosis. We postulate that FAP is not only a marker of disease but influences the development of pulmonary fibrosis after lung injury.'
Treatment option choice is not great and includes steroids /
'What side effects can corticosteroids cause?
Corticosteroids carry a risk of side effects. Some side effects can cause serious health problems. When you know what side effects are possible, you can take steps to control their impact.
Side effects of corticosteroids taken by mouth
Corticosteroids that you take by mouth affect your entire body. For this reason, they are the most likely type of corticosteroid to cause side effects. Side effects depend on the dose of medication you receive and may include:
A buildup of fluid, causing swelling in your lower legs.
High blood pressure.
Problems with mood swings, memory, behavior, and other psychological effects, such as confusion or delirium.
Upset stomach.
Weight gain in the belly, face and back of the neck.
When taking corticosteroids by mouth for a longer term, you may experience:
Problems with the eyes, such as glaucoma or cataracts.
A round face, which is sometimes called moon face.
High blood sugar, which can trigger or worsen diabetes.
Increased risk of infections, especially with common bacterial, viral and fungal microorganisms.
Bone fractures and thinning bones, called osteoporosis.
Fatigue, loss of appetite, nausea and muscle weakness.
Thin skin, bruising and slower wound healing.
What side effects can corticosteroids cause?
'Corticosteroids carry a risk of side effects. Some side effects can cause serious health problems. When you know what side effects are possible, you can take steps to control their impact.
Side effects of corticosteroids taken by mouth
Corticosteroids that you take by mouth affect your entire body. For this reason, they are the most likely type of corticosteroid to cause side effects. Side effects depend on the dose of medication you receive and may include:
A buildup of fluid, causing swelling in your lower legs.
High blood pressure.
Problems with mood swings, memory, behavior, and other psychological effects, such as confusion or delirium.
Upset stomach.
Weight gain in the belly, face and back of the neck.
When taking corticosteroids by mouth for a longer term, you may experience:
Problems with the eyes, such as glaucoma or cataracts.
A round face, which is sometimes called moon face.
High blood sugar, which can trigger or worsen diabetes.
Increased risk of infections, especially with common bacterial, viral and fungal microorganisms.
Bone fractures and thinning bones, called osteoporosis.
Fatigue, loss of appetite, nausea and muscle weakness.
I took the hint in the tweets to be the tweet itself; an exercise in hand-holding to show that nothing untoward had happened and still drilling away happily. Probably prompted by the jitters in the sp on Friday (people wondering what bad news, if anything, had leaked) upon which I de-risked myself a little, albeit briefly as it turned out.
The moon is pretty visible atm; just over half moon and waxing. If it's the moon in the pic it looks a bit small and I did wonder if it's a bright planet being exaggerated by a poor camera at dusk but if others also think it's the moon then likely the photo is current.
I looked for camera metadata in the image (having saved it) but X must have stripped it out (or HE1 stripped it out before posting). There's no info at all.
Quick PS Mjapac,
I immediately sank 1/3rd into another share I hold and which also fell today but the 2/3rds is sitting in cash and might well go back into HE1 whatever the results of the current drill.
If the news is good then I might jump back in at a higher price with less risk. If the news is bad I might jump back in for the second drill and with roughly the same number of shares as I held yesterday.
Mjapac, yes of course. I'd added to my holding with 6p offer and at 4p when the drill broke so that it was bigger than I want to risk. My intention was always to sell some before the results and hopefully at a profit with a rise at spud and as the drill proceeded. If anything I've held it longer than intended as the sp didn't rise as it did last time.
I was doing dummy sells around 6p yesterday but then sp fell back, market went haywire, and I'd hoped for a chance to sell for more today. It just didn't come.
I lost quite a lot on eve sleep plc last year, and on other things 4D etc.. I can't afford to do the same again. Just risk management I guess. My wife thinks I'm a gambler / bonkers for selling HE1 at a loss but it actually seemed the most logical course for me right now.
If the shares go above 10 or 11p I'm in profit again ; perfectly possible (more than likely) on good news.
I did look and there isn't a Saint Lorna but there is in fact a St. Blaise! Was a man but maybe he will put in a good word for us! (not that I'm a believer that kind of miracle.)
Me too I'm afraid, late afternoon. Sold 1/3rd of my holding, some at a profit and some at a loss.
Decided that what remains will do well if they hit helium, and I live to fight again if it's the alternative. A bit of me also feels that success is now more likely, just to spite me.
My sell is showing as a sell.
Hi Ant, my spelling mistake! Or just maybe 'auto correct'. Defo UK passport :-)
I do have a bottle of whisky in the cupboard. Oban 10 year old Single Malt from a trip we took including a distillery tour, more than 10 years ago, alas still not opened...
Tend to drink a beer myself, usually bitter / IPA :-) Or red wine.
So I guess I am more with Latorre when it comes to my tipple!
We should all have a toast to our success if this drill result pans out as we'd wish for. I'm really not holding my breath, not taken a chance to de-risk so ought to be more anxious than I am. I take comfort from the fact that it's not gone the way of last time, so far.
All the best to everyone.
Wolf, I think (from my own viewpoint, still having too many shares for my own comfort) that you're correct the second time and it's just 'de-riskers' outnumbering 'in-for-a-punters' as the weekend bears down.
Thanks indeed Paul, for keeping us updated.
'For further inquiries:
Tiziana Life Sciences Ltd
Paul Spencer, Business Development and Investor Relations '
Pasting a link for Ticino that I've pasted before;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487063/#:~:text=FAP%20is%20known%20to%20be,%2Dassociated%20fibroblasts%20(CAFs).
These are some extracts:
'FAP in Cancer
While FAP expression in normal tissues is usually low or undetectable, it is overexpressed in many cancers, including 90% of carcinomas. FAP is known to be overexpressed in breast, colorectal, pancreatic, lung, bladder, ovarian and other cancers. In these cancers, FAP is usually heavily expressed in the stroma,'..
'Breast Cancer
While most studies confirmed the existence of FAP in the stroma surrounding breast cancer cells, one study identified FAP expression in the breast cancer cell lines themselves'
'Colorectal Cancer
In human colon cancer specimens, FAP expression has been identified in both cancer cells and in adjacent stromal cells, including myofiboblasts, fibroblasts and endothelial cells'
'Pancreatic Cancer
Ninety percent of pancreatic ductal adenocarcinomas (PDAC) demonstrate FAP staining. FAP expression has been identified in both the tumor stromal compartment as well as PDAC tumor cells and pancreatic cancer cell lines'
'Gastric Cancer
Gastric cancer consists primarily of two types: intestinal-type and diffuse-type. Both types express FAP, however intestinal-type does so to a larger degree. Unlike other cancers, in gastric cancer the majority of FAP expression is localized to the gastric carcinoma cells and is only weakly expressed in stromal and endothelial cells'
'In summary, FAP expression’s impact on clinical factors such as tumor type and clinical outcomes is highly variable and depends on cancer type, histological type, tumor localization and specific cellular expression (stromal vs. malignant cells).'