Member Info for crumbs

grim hold:) ... that is actually a good honest write up of where we are

50 quid a share would bb better :)

Because she never sleeps..... really scancells pipeline could fill a big pharma... modi 2 now...and what is this all about?

'Novel combinations to prevent ‘tumour escape’

Exciting yes... very happy to hear modi1 manufacture now seems to have cleared it's hurdles .... 2019 is going to be quite a year here I think

scancell never sleeps! :))

Slides of CD4+ cells might be of interest to you... scancell linked to the research they are contained in a while back... research paper costs to view but ...we can see the graphics contained here for free :)

https://twitter.com/BiotechRadar/status/1023876992461156352

http://www.scancell.co.uk/file-manager/PDFs/sclp-corporate-update-15th-feb-2018.pdf

page 12

1. Citrullinated peptides (Moditope) are injected
2. Moditope peptides are taken up by the APCs
3. APCs present the peptides to CD4+ killer T-cells
4. Primed CD4+ killer cells enter the tumour
5. Stressed tumour cells undergo autophagy and express citrullinated peptides
which are taken up by the APCs
6. CD4+ T-cells recognise citrullinated epitopes presented by APCs and release
IFNγ at the tumour site – this induces MHC class II expression on the tumour
cells
7. Primed CD4+ killer T-cells destroy the cancer cells expressing shared citrullinated peptides

I notice the same curmudgeon turns up at every AGM and JC cut him off this time when he was going on about sp... but its good that guy goes and gets his frustrations out at every AGM... only thing is inanaco was right... too much time was spent on Q&A on issues the BOD can't really answer they can't say we have a super plan to get sp back to 20p lol... I would have rather more tech and progress questions myself... want to know more about nanovesicle delivery and the van geest ImmunoBody vaccines want to know what this means on the Modi 2 presentation about it 'Could target tumours in event from escape from citrullinated Moditope vaccines' ... are we talking about combination of moditopes?... are BioNtech interested in testing out modi 2 in TCR too.. think listening to LD seemed like it ... certainly seems BioNtech will be our first deal... a non-dilutive non-Ip losing one at that... And the amount of work scancell now have is just incredible

Yeah what he was trying to get across was scancell are at the point of getting human data all the preclinical toxicology testing in mice and manufacturing work having (almost) been complete... following which will come money

Still, think he screwed up with that phrase and moved on from that question in a relatively very fast manner :)

Yeah, not even Ichor can mess it up!

The GC results date did slip once already :) but least give our team longer to work on project blueprint which when you see the amount of work LD is already doing which is phenomenal!!! And that is just direct scancell stuff she does even more than that.... honestly she is someone who should be given £100 million as you know she will use it to beat cancer...hopefully a BioNtech deal on TCR use of moditope is forthcoming at the beginning of 2019

Like I say I do not think it involves a device but hopefully, we will learn more about this

nana I do not think it is a device be nice to get clarity on just how it works though... be interesting what Timbo can get out of CH tomorrow as I know he is keen on this issue too and will specifically ask about it... I wonder if it will be CRUK who do whatever deal is needed with the third-party nano company ... all very interesting especially seeing as there are the 3 van geest immunoBody using vaccines in the background too...

Not all work but most and scancell already spent some pre CRUK trial money on SCIB2 doing what?.... testing a nano delivery method I would say seeing as that is in the last presentation... but we shall see

Thanks bob for the first report out of the bunker good to know there are survivours... anything about nano delivery of SCIB2?

Yeah.. she then burst into song though

It must be calculus buying back the shares aggie said they sold the other day :0

The biscuits must be good!

Sounds like only the Yorkshire contingent will get out alive.. hoping some from Nottinghamshire do too :)

Thursday
https://www.proactiveinvestors.co.uk/register/event_details/174