Member Info for CHELSEA7

Re your observation about utilising prisoners from Ivys link..........

The autonomy of the volunteers is of paramount concern. This means that the informed consent process must be robust (e.g. no children, no prisoners, multiple tests of comprehension).

Differing views from that link.............

The notion of a human challenge trial for Covid-19 was jump-started by a March 31 article in the Journal of Infectious Diseases, which made the case that the nature of the global emergency warranted consideration of unconventional approaches.
Co-authored by Nir Eyal of Rutgers, Marc Lipsitch of Harvard, and Peter Smith of the London School of Hygiene & Tropical Medicine, the piece concluded that while a human challenge study would not be without risks, "every week that vaccine rollout is delayed will be accompanied by many thousands of deaths globally."
But members of the NIH's Accelerating Covid-19 Therapeutic Interventions and Vaccines (ACTIV) Vaccines Working Group said earlier this month that challenge trials would not speed up vaccine development.
In a commentary published in the New England Journal of Medicine, ACTIV members wrote that using controlled human infection models to support vaccine development requires "essential criteria" to limit the risk for participants and could take "one to two years."
"A single death or severe illness in an otherwise healthy volunteer would be unconscionable and would halt progress," they wrote.
They said it would be unethical to organize an experiment in which people were deliberately infected unless there were a rescue therapy -- a treatment that can save lives -- which does not exist for coronavirus.
"Large, randomized, controlled trials of SARS-CoV-2 vaccines are currently the most efficient, generalizable, and scientifically robust path to establishing vaccine efficacy," the authors concluded.

Does anybody know how much time volunteers will have to spend in a virus isolation unit.

Thinking about jsands observation about volunteers from H.M.P leading to remission, which I guess will be cost effective in time too.

An interesting BB to catch up on today.

TF, I was asking whether anybody had heard from you over the weekend, good to see you back and my deepest condolesces for the loss of your sister. Wishing you and your family a long life.

"". I sometimes think a lot of professional people find talking about money a bit distasteful.""

Well that is what differentiates a salesman from a closer.

Tell me Dalestar, from your experience have you found too many collaborations are signed without any financial commitment??

Ruck,

Genuine question, but we employed a top firm of solicitors whose expertise was negotiating deals between pharmaceutical companies. This often comes up, our inability to negotiate deals, but do you think that CH is just left, or anyone else, to negotiate on his own??

Ruck, you seem to be confirming my feelings that your negativity has no respite...................

RuckRover

Posts: 3,054

Price: 5.35

No Opinion

"""RE: Thinking aloudToday 15:41
Dalester,
Good post. Do you think CH is the man to make all this happen?"""

Certainly agree about Dalestars post, it was something that we haven"t tended to discuss over the years, and I do feel we are about to see something from that list occur soon.

But your actual question about CH?? Well I admire your closing skills in asking a question at this time of that nature and with sentiment being low anyway I doubt it would have a happy ending. Without getting involved in an endless debate, where many feelings are running high on our latest fall and absence of deals, I would only say we just don"t know what might being discussed at this very moment and being such a price sensitive subject we can hardly expect an update on any impending deal. I do feel though that from my first opinions he was presenting with more confidence each time we heard him, but a true judgement of him can only be made when we see monetisation of assets/IP. It seemed to be generally accepted that any deals from impending trials would come after new data had been collated, but in his role as CEO, we as a company have entered into a few collaborations that could easily bear fruit, and even then someone could argue that that was not necessarily down to him. So for me it is a very speculative question at a time when many feel disgruntled, but expecting more negative comments than positive what would that teach us anyway?? On top of that there are a few of you going to extraordinary levels to attack whaever Inanaco says and I reckon any debate will end up with 3 or 4 of you arguing against anything Inanaco says.

So that I"m afraid is IMHO, and you will know from that question and a feeling it is all too negative what I am talking about.

Anyway, till tomorrow and ATB

GN

Buys 139,553

Sells 112,659

But down 2.78% from 14 trades. 6 of them being 1k sells. I just get a feeling we have some good news to come too

Ruck, fair enough comments, we both guesstimated 50p and I didn"t realise we both had the same average, although I chipped off a bit at 5.533 (as ever down already!!). But who knows, I would take 50p tomorrow dependant on how we got there, but it can only be a guess as too many things could happen.

Still seems like we always talk about the risk, but the last few months offered rewards too, especially for those who were not LTH and reaching 130 trades a day for a weeks there were plenty of them. Feel much more comfortable now with a 15% trading pot, especially at this level

Really don"t know WTP, very difficult to read any patterns ATM

And 6 x 1k sells now

For 23k

5.10/5.40

Last sell 1k at 5.12, that is 5 sells of 1k today from 11 trades.

Buys 117k

Sells 108k

Last hour, something happening...............

Great post Dalestar, far from doom and gloom is it?

Buys.........117k

Sells..........67k

And 4x1k sells now!!!!

At 5.35........................

Just for 5k.

Ivy really not interested in that carp, I base my judgements on what I hear, what I read, and we spoke on the phone.........remember!!!! So not interested in the populist, post for recs against inanaco or how wonderful you are, IMHO you really are not. That being said, wish you no harm at all, but to say you don"t want the SP down after telling us you were so lucky to have sold higher, missing out you bought for your trading pot just after I sold at 6.40 don"t work for me. Never has.

5.421, 5.40 and 5.39 have been paid this week, first and only buy today 5.44!!

LL/Burble,

Well said LL , and I think one factor people can miss is we are not alone in this project. We have two active partners, and both financially really want this to happen, we benefit too from their contacts and resources and funding is something all Hospitals and Universities need for R & D, so this is hardly unique in that respect.

I think a lot of us had too high expectations with regard to timelines and see other vaccines specifically for COVID 19 as competition where LL and Burble have made some very good points.

For 20k, and a feeling more to come.