SLR14 inexpensive compound12 Nov 2021 17:16
@gerdosi
Wow, early robust IFN response makes adaptive immunity almost obsolete in SARS2 infection.
“In immunodeficient mice carrying chronic SARS-CoV-2 infection, SLR14 elicited near-sterilizing innate immunity in the absence of the adaptive immune system.”
https://news.yale.edu/2021/11/10/immune-system-early-responder-can-combat-covid-19
" The molecule, known as SLR14, is a simple, easy to manufacture, loop of RNA that can trigger the production of interferons, a group of proteins produced by immune cells that are key to the body’s innate, or initial, response to infection.
Multiple studies have shown that COVID-19 patients who produce high levels of interferons have far better outcomes than those for whom interferon levels are low during early days of infection. "
“SLR14 therefore holds great promise as a new class of RNA therapeutics that can be applied as antivirals against SARS-CoV-2,” said Akiko Iwasaki, the Waldemar Von Zedtwitz Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale and corresponding author of the paper.
“Moreover, because this RNA-based therapeutic approach is simple and versatile, our study will facilitate pandemic preparedness and response against future respiratory pathogens sensitive to Type I interferons.”