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Good info Bob
Again CST1 is still missing from that article
CST1 TBC...
as posted previously, Top spot, wonder what might appear there soon ;)
https://clinicaltrials.gov/ct2/show/NCT04746183
GLALTH's sweaty fingers are crossed
Well, at least 737 get mentioned...
https://www.investorsobserver.com/news/stock-update/sierra-oncology-srra-shares-decline-after-updating-guidance-on-developmental-timeline-for-momelotinib
Sareum playing a blinder, they have a plan only the elite know of, good luck team Sareum ;)
Dr Tim Mitchell, CEO of Sareum Holdings plc, said: "This new subscription is Sareum's fourth since 1 June this year, reflecting the strong and continuing interest in our proprietary TYK2/JAK1 development programmes in autoimmune diseases, including the immune overreaction to Covid-19, and cancer. With the funds raised during this period now totalling over £4.5 million, our financial position has been significantly strengthened and we are looking forward to completing the preclinical studies with SDC-1801 and advancing it into clinical development, and to progressing the preclinical development of our second TYK2/JAK1 inhibitor SDC-1802."
Now we patiently wait for double digits ;)
That's why its stinks, they really haven't delivered yet, 737 was licenced, preformed, they took on sticky Momo, and now AZ 's .. for 8mil??
Oh ... 3 years later and were still waiting on 737??
Something really stinks, Dilly Dallied long enough
Once 1801 lands, Tim should take Sierra to the cleaners, rinse and repeat cycle, then dump them out to air dry for all their neighbours to see, who knows how many life's could have be saved with 737!!
sorry for rant but but really is unbelievable considering....
Good morning all
https://www.medicalbuyer.co.in/a-giant-trial-of-covid-19-treatments-is-restarting-here-are-the-drugs-its-betting-on/
Thoughts, could we be joining in?
We are pursuing an innovative development plan for SRA737, which is currently being evaluated in two Phase 1/2 clinical trials in patients with advanced cancer. SRA737-01 is intended to evaluate SRA737’s potential to induce synthetic lethality as monotherapy, while SRA737-02 is intended to evaluate the combination of SRA737 potentiated by subtherapeutic, LDG. Concurrently, we are conducting preclinical research evaluating SRA737 in combination with other DDR-targeted agents, including poly ADP ribose polymerase (PARP) inhibitors, as well as with immuno-oncology therapeutics, that may guide a potential next wave of clinical development for our asset, possibly further broadening its therapeutic utility.
SRA141, a potent, selective, orally bioavailable small molecule inhibitor of cell division cycle 7 kinase (Cdc7). Cdc7 is a key regulator of DNA replication and is involved in the DDR network, making it a compelling emerging target for potential treatment across a broad range of tumor types. An Investigational New Drug Application (IND) submission to the U.S. Food and Drug Administration (FDA) has been completed in order to commence clinical trials with this drug candidate.
Sierra Oncology retains the global commercialization rights to both SRA737 and SRA141.
from their website:
https://www.sierraoncology.com/sample-page/
Great posts today, efforts greatly respected ;)
Glad I've been working, or I'd be glued to the pc!
Suspense is killing me! cant wait to see how Sareum's plans to go forward, but for sure Kinase inhibitors are the way forward for many treatments, and were sitting pretty at the top
Lumpy delayed trades again, only a good sign, buys or sell, its the making of Sareum's rerate ;)
https://www.msn.com/en-gb/news/uknews/mass-vaccination-of-children-against-covid-planned/ar-AAMTVjl?ocid=entnewsntp
I wonder why ???
Bit of humour
https://www.msn.com/en-gb/news/world/mystery-plaster-on-kim-jong-un-s-head-reignites-speculation-about-north-korea-leader-s-health/ar-AAMSQF2?ocid=entnewsntp
Recon he had a TYK or 2 removed , sorted his diabetes and no baldness yet ;0)
https://www.evaluate.com/vantage/articles/news/deals/sanofi-translates-its-mrna-interest-big-bucks
Scroll to the table, ummm, mouth watering deals ;)
Fantastic CW free posts this weekend, calm before the storm??
Oh and we'll know they will be back ;)
SAR at a pivotal point that no body could have predicted, originally all cancer but WHO could have predicted this shower shyte that would that landed and would cripple the world.!!
Watched many disaster and horror movies, but Planet Earth deals, and moves on with real life events. (Ice age !)
Without a doubt I can see this becoming a blockbuster movie one day.
SARS V's SAR ;)
GLALTH's its been a fantastic voyage, we've nearly landed ;)
The results of the project found that SDC-1801 reduced the levels of cytokines associated with Acute Respiratory Distress Syndrome (ARDS) in human lung cells infected with SARS-CoV-2 and demonstrated a profile that was superior to the anti-inflammatory steroid dexamethasone
What better than the "Miracle drug dexamethasone"
https://www.msn.com/en-gb/health/medical/miracle-drug-is-life-saving-against-covid-gps-claim/ar-AAMNnSZ?ocid=entnewsntp
Massive rerate due ;)
played with 9's today, what a great ride, bumpy as we go ;0
Oh no, China cases increasing, wonder if the Wuhan lab is anywhere near the airport ;)...
https://www.msn.com/en-gb/news/world/china-suffers-most-extensive-covid-outbreak-since-wuhan-delta-strain-sparks-chaos/ar-AAMKw2n?ocid=entnewsntp
Need for treatment is dire, have a great weekend everyone
Great news, well done team Sareum, patents in place.
Share suspension could land any time "takeover negotiations" ;)
Value increased once again, what's not stopping Sareum tickling the teen's today..
Apologies, but I wouldn't want to out of this until the Agile news drops ;)
https://jobs.taskandpurpose.com/jobs/74560253-scientific-manager-clinical-microbiology-at-gsk
well GSK must have something up their sleeve we don't know about yet, hummm wonder what it could be!!! ;)