Member Info for Bella6532

PAH00...a spot of bedtime reading for you...it includes darpins..
https://www.labome.com/method/Aptamers-and-Affimers.html

The Mologic deal was announced in Feb 2021 and at the same time Avacta switched to fti consulting and didn't mention the switch...why? Are they actually gate keepers and there to broker a pharma deal...it was at this point Avacta also started to go quiet on us...

'Alongside their work on diagnostics, the UK government's aid is also supporting Mologic in the development of a COVID-19 vaccine candidate for further evaluation.'
https://formlabs.com/covid-19-response/covid-19-rapid-diagnostics/

'Avacta Group plc (AIM: AVCT), the developer of Affimer biotherapeutics and reagents, is pleased to announce that collaborative work with the Centre for Virus Research at the University of Glasgow has shown that Affimer reagents which bind to the SARS-COV-2 virus spike protein prevent infection of human cells by a SARS-COV-2 model virus and therefore provide a potential therapy for COVID-19 infection….

Work is continuing with Professor Bhella to further study the way in which the Affimer reagents prevent infection and Avacta is using this growing body of data actively to secure a large pharmaceutical partner to develop these potential therapeutic candidates rapidly.'

https://avacta.com/update-on-affimer-therapy-for-covid-19-infection/

If you Google...Mologic Safety Data...you should get the pdf link for their MSD pdf..page 2 item 3.1 reads per the abstract in the tweet.

Secondly and this is now pushing on a big boundary...I've wondered for some time why Mologic was so happy to obtain CE for us...one could argue it was simply to get production business but then I realised Avacta and the University of Glasgow were running trials in 2020 using affimers as a potential Covid therapy. Mologic have also received funding towards their Covid vaccine development. Then along comes Soros and his mob. Is there a much much bigger picture brewing on this or has it been shut back into the closet for the moment.

Orphidian...the original Avacta video showing how LTFs work talk about affimer coated beads. It was the saliva version. Does the current LFT not use the same? There was no mention back then of antibodies unless the beads contained them.

Oh the little tinkers...at their little games again...
11-Jan-22 17:05:43 73.536 49,475 Unknown* 36.38k O
11-Jan-22 17:04:07 74.50 33,500 Unknown* 24.96k O
11-Jan-22 13:49:31 73.61 27,701 Unknown* 20.39k O
11-Jan-22 13:49:31 73.61 10,335 Unknown* 7,608 O
11-Jan-22 13:49:31 73.61 32,197 Unknown* 23.70k O
11-Jan-22 13:49:31 73.61 49,475 Unknown* 36.42k O
11-Jan-22 13:49:31 73.61 2,415 Unknown* 1,778 O
11-Jan-22 13:49:31 73.61 16,070 Unknown* 11.83k O
11-Jan-22 13:49:31 73.61 -138,193 Unknown* -101.72k O
11-Jan-22 16:41:28 70.25 100,000 Unknown* 70.25k O
11-Jan-22 16:35:11 75.00 22,907 Sell* 17.18k UT
11-Jan-22 16:29:40 77.70 2,000 Buy* 1,554 O
11-Jan-22 16:29:28 77.70 5,000 Buy* 3,885

It was the National Framework RNS/note on the Medusa19 site where tests (plural) are referred to. 'and Avacta’s professional use AffiDx SARS-CoV-2 Antigen Lateral Flow Tests.'
Is it merely a typo or as you say is there more than one?
'This Framework Contract allows the provision to all UK Government Departments and Trusts across England, Scotland, Northern Ireland and Wales subject to access agreement signature and Schedule 6 pricing, to supply the Rapid Saliva Protein Test (RSPT) and Avacta’s professional use AffiDx SARS-CoV-2 Antigen Lateral Flow Tests. '

Icecool...remember the wording...tests (plural)...I did mention this a couple of times and asked Avacta about it in Sept 30 Presentation Q&A but never got the answer.

From Avacta website...I posted the link earlier...
I think this now tells us what Avacta is up to...a perfect time to tweak...improve, improve, improve...and perhaps the tweaking has been done and it's now time to insert and roll the TT update...remember all those tests which got a pass will soon have to reapply.

'26 Mar 2015
Synthetic antibodies. Where does Affimer technology fit in?
Synthetic antibodies, also commonly termed aptamers, have started a step-change in the antibody world. After their slow beginnings of scientists tinkering with alternative affinity reagents in labs, synthetic antibodies are now coming to the fore as reagents for use in biological research and medicine. This is evidenced by the high investment in and numerous acquisitions of companies that have the capabilities to produce these marvellous molecules.

Being smaller in size than their traditional monoclonal and polyclonal counterparts, allows synthetic antibodies increased access to tissue and also the smaller, more hidden epitopes that antibodies can’t reach. They are not limited by the immune system, which allows us to generate synthetic antibodies to a wider repertoire of targets including highly toxic targets and to proteins that show a high degree of homology, theoretically it is possible to generate synthetic antibodies to any target one could desire. The fact that these molecules are not generated in mammalian systems also gives them the advantage of less variability between batches, thus a more reliable product, that are easily modifiable with different dyes and labels according to users’ needs.'

Icecool...haha...thanks. That was going to be my next post...I came across that when the site was updated and I was getting all picky about it...I didn't realise the significance until today.

Monkshood...you might find this of interest.
https://www.mercia.co.uk/plastic-antibodies-could-improve-success-of-rapid-covid-tests/

Maybe they've been working on using synthetic antibodies and now have it cracked and are going to do the swap out...

Monkshood...any thoughts re aptamers?
https://avacta.com/2015-03-26/

The Deepverge products using our affimer are combined with an aptamer.

Sharesol...if the market/broker knows data from Phase III is imminent or large shorters ready to close and with no free fundraising shares floating about, this RNS is great time to load up. This mornings drop was not due to sales they opened 20% down. The bad cop good cop call..but in this case bad news then good news or bad new then fill big order...
It's a paper loss and by the end of this week we will be back up to the 116 mark without news...
Keep the faith..

Did we have to include an antibody to get through old verification specs...ie not validation specs yet written up for new affimer tech only.
Sorry haven't ploughed thru the zillions of posts today.
The first we saw affimer plus antibody was on Mologics Safety Data pdf point 3.1.
Dud they insist on developing our LFT with both affimer and sntibody to more easily get validations/CE through etc.
Just a shot in the dark on this point.

Sorry Magnet30 but who's test would you rely on then? If you are so worried regarding your own health situation knowing how LFTs only detect any virus once you are most likely infectious why are you relying on them at all and allowing other people into your house.

'Dr Alastair Smith, Chief Executive Officer of Avacta Group, commented:
"We are delighted to confirm that the AffiDX® SARS-CoV-2 antigen lateral flow test detects the Omicron variant. As this variant is more infectious, it is important that it can be detected in individuals with higher loads using lateral flow tests so that its spread can be slowed down.'

His comment re higher loads is what leads me to think they knew about it back then and have been working on it since.

Adding in the tech transfer detail is key to this IMO...they are telling us that's all done and dusted and all that's needed is a tweek to the antibody element..no biggie guys...

momin786
'15th Dec 2021 7:00 am RNS AffiDx® lateral flow test detects Omicron variant'
Their data will have told them how sensitive the test is and my guess is they've been working on it since then. Todays RNS is in response to Germany's reaction and the weekend press to cover their buts on affimer tech. It clearly says it's not the affimer which us the problem. I would also guess they will be back with a more sensitive test in a matter of days not weeks. Thy don't want to be grouped with the rest of the LFTs out there so they've taken themselves out of the picture. Great move especially if it will help FDA and PD approvals if the dialogue is favourable.

https://www.reuters.com/business/healthcare-pharmaceuticals/covid-19-test-maker-avacta-pauses-sales-antigen-flow-test-2022-01-10/

https://www.reuters.com/business/healthcare-pharmaceuticals/covid-19-test-maker-avacta-pauses-sales-antigen-flow-test-2022-01-10/

Apologies if already posted.
https://www.reuters.com/world/europe/germany-assessing-reliability-antibody-tests-omicron-minister-2022-01-09/