Firering Strategic Minerals: From explorer to producer. Watch the video here.
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NIH reports that BRII-196 and BRII-198 (Monoclonal Antibody ****tails) from Brii Biosciences has 'closed enrollment', in not meeting criteria for inclusion in ACTIV-3 for in-patients.
However, BRII-196 and BRII-198 are both listed together with SNG001 in the activ-2 trials. Will they also be removed from the ACTIV-2 list?
The monoclonal antibody therapy VIR-7831 from GSK-Vir has also not met criterai for ACTIV-3.
NIH article at: https://www.nih.gov/news-events/news-releases/nih-sponsored-activ-3-clinical-trial-closes-enrollment-into-two-sub-studies
Just goes to show how energetically (and ruthlessly) these trials are being studied. I assume other candidate treatments will replace them.
Yes still on ACTIV-2 but they'll be watching it very closely.
The NIAID-supported ACTIV-2 trial will continue to test the BRII-196 and BRII-198 combination monoclonal antibody therapeutic regimen in people with mild-to-moderate COVID-19 who have not required hospitalization. It is being overseen by the same DSMB that oversees ACTIV-3, and the DSMB does not recommend any changes to ACTIV-2 at this time.
The ACTIV-3 trial is now showing three out of the four listed candidates as 'ended' - Eli Lilly's LY-CoV-555 due to 'lack of clinical benefit '.
https://www.nih.gov/activ/nih-funded-activ/activ-associated-clinical-trials
Just re-read my posts about ACTIV-3. I put this up purely as an update on this dynamic situation.
I take no pleasure at all from a potential treatment failing - we need different treatments to succeed for each stage of the infection and SNG001 is only one of them.
Goes to show that there trials are not a walk in the park
Scientists have identified 16 cases of another new variant of coronavirus in the UK.
Public Health England has designated it as a "variant under investigation", meaning it is on its watch list but not one PHE is immediately concerned about.
It does have a mutation in common with the South Africa and Brazil variants, however.
That genetic change, E484K, may help the virus evade immune attack.
It's not unexpected that variants are appearing or that they will continue to change - all viruses mutate as they make new copies of themselves to spread and thrive.
That's y I hate people taking it for granted and talk about making lots of money we must not get carried away let's hopefully get some good news soon
Volatility - I have so many green boxes that I never see their posts, whoever they are! I broke my British '13 consecutive green boxes' record today ...
GKB- it’s my belief we will receive an RNS Within the next few trading sessions. I genuinely think they have advanced SNG into Activ 2 P3. The speed of recruitment into these trials and number of sites could fill P2 in a matter of days. It’s also the Same DMC overseeing Activ 2. They would of discussed multiple treatments when removing MABS. It may be a complete shot in the dark, but I think recruitment into P3 has commenced. Remember IAW trial protocol only a few individuals in the company will be informed. We all know the priority is for an agnostic treatment. I only know of 1 on Activ 2 it would make sense they prioritised recruitment into that treatment.
Graham
What you suggest is unlikely since they haven't released the revised protocol for P3 non I/V drugs yet unless I have missed it. Also please write English. They wouldn't OF discussed anything . They may HAVE discussed something.
Spinnaker- Maybe correct your own mistakes. You absolutely must upgrade your IT equipment, maybe something with a comma option. You type the longest sentences ever.
Actually, Spinnaker, I believe the word that should've been used was 'would've ', not 'wouldn't of', haha.
Well...'wouldn't have'.
And to the substantive point?
No point, it's not a race or competition, I was just trying a light laugh. I'm not really of the opinion that LTH's should be combative with each other (not that you are or i am), rather we should be standing firm together.
Hi Rum (a man after my own heart judging by your name). I'm not intending to be combative just getting increasingly pedantic in my dotage. I do understand your light heartedness. I just can't stand people thinking that 'of' is part of a verb or denotes any of the past tenses. By the way your proposed contractions are perfectly proper English. Yes you are correct that -'ve -has been converted by some people to -of- instead of -have-.
My last post question was about the substantive point I raised, not the use of English. I have just checked and although my internet skills are not that great I cannot find a version 4 of the Activ 2 protocol. If that has not been finalised or published there is no P3 protocol for SNG001 to progress to. Therefore the best that could happen as and when the P2 was completed, or otherwise ready to roll on to P3, would be for the programme to pause. Not an ideal scenario. My point was that that is unlikely and therefore Graham's proposition also unlikely.
Check out p67 https://fnih.org/sites/default/files/final/pdf/Protocol-activ-2-A5401-version3-dated12.22.20.pdf
I think that document is v3 of the protocol dated 22 Dec 2020 and we are waiting for the protocol for P3 for the 2 non-infused drugs currently in the trial, one of which is SNG001.
Best wishes to all
Spinnaker
Tommy. Thanks for that. I take your point but so far the info published has been timely.
Spinnaker
Why would SNG001 not also be included on ACTIV-3 for in-patient treatment? There will now be places to fill on ACTIV-3.
After all, Brii-196 & Brii-198 are/were put on both ACTIV-2 AND ACTIV-3?
Or do the NIH feel this would be unnecessary, since Synairgen is already running its own P3 for US in-patients?
Yep you don't need to do two P3 hospital trials.
I am paraphrasing SH but I believe that interferon works best in the earlier stages, to help the body's natural immune system to kick in.
Also, maybe they just do not want to shoot themselves in the foot. Or maybe it is in part a commercial decision - get approval for outpatient use first; secure that before trialling in-patient use.
SH said these wouldn’t be effective if I recall. He knew way before the results. He also knows SNG works well.
Chippy - but if SH thought SNG001 'wouldn’t be effective' after admission to hospital, why bother to do a P3 as well as the Home Trial?
P2 was for hospitalised patients and it returned good results. Surely the issue is not that SNG001 might not help patients in hospital and on exygen but that, caught earlier (at home) it would be even MORE effective? (sorry, I'm not bold-shouting but you can't use italics on this BB)
exygen? I've discovered a new gas ...