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Morning ALL,
Dalestar, don"t we just, heres to an epic and sensational time
I guess this means that we are approaching the point at which all these new appointments and cash at the bank will start to prove their value. You can see the ducks getting put into a row after years of steady scientific progress. This is unlike so many other companies who either get everyone too excited too early and dont follow through or who fail to support initial success with the right people in the right seats. There is a sense of considered purpose about Scancell at the moment that has not hereto been particularly evident. I like it! It now seems like we have a clear, thought-through path, and that the time to start to monetise the assets is becoming visible on the near horizon. The next 12 months could be epic , the next 4 or 5 years sensational.
Burble,
Mass delivery and cost should not be an issue - the Serum Institute of India have started to ramp-up manufacturing (I think with Gates Foundation funding but it has not been clear from press releases).
https://www.prnewswire.com/news-releases/serum-institute-of-india-initiates-manufacturing-of-codagenixs-intranasal-live-attenuated-covid-19-vaccine-candidate-301135221.html?tc=eml_cleartime
On that us a p1 intra nasal Vac which was agreed about 2 months ago.
That will be fine at Whitechapel facility and will form no part of Govt slots we are discussing
Nomlungu,
Codagenix has some really interesting technology and demonstrate how far synthetic genetic construct technology has come in the last 10-15 years or so. Their codon de-optimisation goes against the flow in some sense of the word. Globally people are always trying to optimise the coding sequence for a DNA/RNA construct to improve yields etc, so going the opposite direction is an interesting take on things.
From a first glance, there are a number of things which stand out for me - firstly, they are using an attenuated live vaccine - which in a way is probably the best in class in some sense of the word. All the proteins are folded correctly, it looks like C-19, it just doesn't replicate as well as C-19. So what immune response that is raised against their version is likely going to be as close to a normal immune response as you could see. All proteins are there, folded in the right way and presented to the immune system how they would be if you were infected with the virulent strain of C-19.
I have a few hesitations though with the set-up. Intranasal means that the control of dosage that actually reaches deep into the lungs is difficult to control. I would imagine they would dose at a higher amount than you would normally. As such, the patient may end up with a higher initial viral load early on, which you would imagine would decrease as the virus replicates slower. The virus does replicate, so in a patient with a limited/suppressed immune system may be problematic (unsure without knowing this field better). A non-replicating virus wouldn't have that same problem, though whether you would be able to obtain a robust immune response in an immunocompromised patient is difficult to say.
Live vaccine manufacture, I would assume is more difficult as there is a chance (though maybe small) that your culture is infected with something else or worse, infected with the real C-19. You also run into problems with delivery of those virus particles to the end patient. So whilst they say that the intranasal is more efficient at mass vaccination, the fact you will probably have to cold chain the vaccine from start to finish will make it difficult to do at any scale. Especially if the virus does not remain active for long after manufacture (meaning you can't bulk store vaccine doses, they're made to order). This in turn will increase costs.
IMHO, novel idea, has potential to raise good immune response, mass delivery and cost may be the issue for more broad deployment.
WTP, I agree the disparity between professions and other industries does raise an eyebrow or two.
Thanks for reminding of those vacancies and one I think that has slipped down the radar a bit is the RNS of 20th September......
24 September 2020
Scancell Holdings plc
("Scancell" or the "Company")
Directorate Change
Scancell Holdings plc, (AIM:SCLP), the developer of novel immunotherapies for the treatment of cancer, is pleased to announce the appointment of Susan Clement Davies as a Non-Executive Director of the Company with immediate effect. For health reasons, Dr Alan Lewis is standing down from the Board as Non-Executive Director with immediate effect.
Susan is an experienced life sciences financier with over 25 years of capital markets and investment banking experience, including Managing Director of Equity Capital Markets at Citigroup Global Markets Limited and most recently until 2018, Managing Director at Torreya Partners LLC, a global investment banking firm serving companies in the Life Sciences industry. Her work at this time included providing advice on M&A, corporate finance, licensing transactions and pharmaceutical asset sales, with clients ranging from large pharmaceutical companies through to private equity firms focused on healthcare. Susan is currently Non-Executive Director and Chairman of the Audit Committee of Evgen Pharma plc, an AIM listed clinical stage drug development company.
Commenting on the appointment, Dr John Chiplin Chairman of Scancell, said:
"On behalf of the Board, I would like to take this opportunity to thank Alan Lewis for the contributions he has made to the Company since he was first appointed to the Board in 2016 and wish him all the best for the future. In addition, I am very pleased to welcome Susan to the Board of Scancell. Susan's considerable experience in investment banking will be invaluable for any potential future licensing and corporate transactions."
Susan Clement Davies commented:
"I am delighted to be joining the Scancell Board at this very exciting time and look forward to working with the team to maximise the potential value of the Company's platform technologies."
Seems we are strengthening in all areas as JC said some 3 years ago, that would take us to about 30 employees on the payroll..............and I am sure is an appointment that raised a few eyebrows here at the time. As I say GN and thanks Ivy and Bunsie for a very balanced discussion, which I am sure will clear the air for the better.
HI C7, yes I noticed that previously too, all those years of studying, qualifications, skills and expertise required for all of those roles and the renumeration is a joke! And i'm guessing these are market rates too and not Scancell/Nottingham uni being tight?
The government should be boosting salries of those working in the Covid field IMO.
Just to clarify what I meant:
"Desirable skills:
- Experience in bioinformatics data analysis
- Home office PIL qualification and experience with in vivo work
- Knowledge of the Human Tissue Act"
So they clearly need expertise/qualifications in dealing with government/home office, hence this would fit with the human challenges trials I guess? (as well as needing someone like that anyway if the Government does decide to use Covidity)
WTP, isn"t it amazing the qualifications needed to earn a salary of just between £40/50k per annum. Not exactly the quickest route to make a million!!
One of the drugs that Open Orphan will be "Human Challenge" testing is a live attenuated vaccine called CodaVax-COVID made by a synthetic biology company called Codagenix (who are also developing an oncolytic targetting Melanoma). Does anybody have any thoughts on the approaches they are taking?
https://codagenix.com/
At a guess Ray and looking back on the Team Challenge, whatever is what called, I think Lindy would be well up for that, it would certainly accelerate our candidate through the early trials process and get headline news for Scancell.
I keep thinking what value Redmile have attached to COVIDITY as a platform on its own, especially when we consider that trials are very much down to the Covid 19 situation. I guess all that will unfold before years end, after all Redmiles external validation for Scancell as a whole has launched us into a new level. I would love to know how Redmile proportioned that value to each platform we have. As I was saying I am hoping we get news we crave for after the OO book closes on the 30th up to the recorded AGM on the 9th November. News that will gradually take us past 20p a share. Much to look forward too, just going with Redmiles validation at 13p a share. Who would have thought that a few months ago when we were languishing at 5.5p a share with SCIB1 trial on hold.
GN guys, just tomorrow and Monday till 12.00 to get the OO applications off. ATB
Going back to those jobs specs (again):
https://jobs.nottingham.ac.uk/Upload/vacancies/files/31301/SCI312520.pdf
"Knowleledge and experience
- Non-viral gene delivery technologies
- Vector design and engineering
- Product commercialization
- GMP/scale up
- Toxicology assessments
- Regulatory experience
Qualifications certification and training (relevant to role)
- PhD or equivalent in relevant subject area. OR near to completion of a PhD
- PhD awarded
- PDRA experience
- PIL licensee course"
https://jobs.newscientist.com/en-gb/job/1401720180/research-scientist-3-positions-available-/
"Desirable skills:
- Experience in bioinformatics data analysis
- Home office PIL qualification and experience with in vivo work
- Knowledge of the Human Tissue Act"
Yes, its interesting about the 3 slots.
I wonder what Lindy's view is on human challenge trials.
You probably couldn't expect the people most at risk to join these trials and these are the very people that need protecting. They probably aren't allowed to join the trials anyway.
So I would guess it is only fit and healthy volunteers who are likely to recover quickly anyway with or without a vaccine.
I am also guessing what you are looking for is for the vaccine to defeat the virus much faster that an immune system without the benefit of the vaccine.
So, having proved the benefits on healthy individuals what happens after that? Do you go for a phase 3 for the people most at risk perhaps with a little more confidence?
Thanks for the 'heads up' in your 16.46 Ivy. If 'Covidity' gets one of those slots it'd be a boost indeed. I hope that UK based projects get all 3 slots and that one of them is Scancell ! GLA
Ivy, Any chance you could name the top three? It's for my own edification.
I'm contactable on several other platforms if you want to DM. ATB.
Likewise Bunsie I simply quoted the word back and yes I used it out of context.
I could probably only hate someone if they transgressed me like hurting someone I loved but never for simply disagreeing with me.Like most been called much worse.
Yep once again will try to only concentrate on what unites us and not divides us.
GLA and sorry to the bored folk
Ivy,
Then that is still hatred......
so I can't comment on that as that is something that is not in my vocabulary .
But can we please move on, he can't post on LSE, which is IMO a shame
ATB to you anyway.
Bunsie
Bunsie,
Have you considered what that hatred is based on.
You make comments about me which are based on pure speculation.
I have absolute no ego whatsoever except when challenged by lies.
Bit like if someone said you were not fit to carry the bags to the plane and you said well actually I fly them and someone said what a huge ego you have.
I would not think that but that is how you accuse me of being .
Not a bad judgement on someone you have never met.
If growing up means being tolerant of lies,bigotry,racism,arrogance,ignorance,and just general obnoxious behaviour and don’t forget I have met him Atheneum I am happy to stay a child.
When confronted by uncomfortable truths about people they support they often call it banter well I call it out for what it is and always will stand up for tolerance, respect,honesty and decency.
So if you want to support him fine but leave me out if it
Ivy,
A long post from you sums you up really.... hatred for one ex poster.....
perhaps time to grow up a little and accept you are just like most of us here, just like most people with balanced comments and observations, who may like a bit of banter and also some very interesting science sometimes.
I do ask why you work both BB's to your advantage, seems a little odd to me, if you want to say it then say it! rather than dribbling between two BB's to massage your EGO.
I will say your contribution here is of value to me most of the time FWIW
My cat needs flea treatment, any suggestions? I could google it of course and perhaps get better info.
I'm done on this hatred route towards a 35K post poster over 8+ years, time to call it a day IMO
ATB
Bunsie
Can"t disagree more Ivy, yes there have been many issues in the past which have tainted this BB badly.
TBH it has been a pleasure recently just exchanging posts, injecting some humour and no personals at all. The only personals in recent weeks have come from you regarding Inanaco.
For me I just highlighted a very good post from you, all input is welcome, I have just asked you to stop mentioning Inanaco badly here. Who else is stopping you from having a balanced discussion?? Nobody.
Do you think balanced discussion is about when you were asking TF to disclose whether he had anything personally against me, from posting from private e-mails we had exchanged, or accepting posts by Aimbig, wishing me dead a few years ago?? Or do you think a balanced discussion involves continually bating this BB??
Well I don"t, I am enjoying this BB now, and want to access posts from a few of you on ADVFN at a time when so much is happening with Scancell. So you think it is good to conquer and divide still on ADVFN?? Well you didn"t like Inanaco doing it here, so I am surprised that a poster with a lot to offer this BB feels that is the way forward. The irony is that is ADVFN now who has Inanaco not here so why knock this BB??? There a few posters on ADVFN with good information, cannot we all enjoy the posts without the personals coming into play constantly??
So as you say................"".I have always posted on LSE but decided to move to ADVFN on SCLP only due to the fact I felt it was impossible to have a balanced discussion on here primarily due to the antics of one poster."""
So why knock this BB now so often, it is equally as bad to what you objected to, but now OK for you to do it???
Sorry Ivy, but for most of us we have been here for 8/9 years now, we can enjoy the good posts and equally ignore what we don"t like without getting personal, that is something this BB is doing, it just doesn"t help if you are stirring it on ADVFN. Anyway ATB, and save the good stuff for here.
To clarify the govt has booked the first 3 slots and paid £10m non returnable deposit plus another £20m to complete so each trial is worth £10m and they are throwing in the Royal Free Quarantine Unit free of charge.
I have no idea if SCLP is involved but assuming the UK govt gives preference to U.K. based candidates I can only think of 3 including SCLP so they would be looking the proverbial gift horse in the mouth imo.
The U.K. government timeline of Jan-May can be altered as they have reserved the slots,own the Royal Free and control who uses it.
As for the other point.I will reiterate my position once more.
I have always posted on LSE but decided to move to ADVFN on SCLP only due to the fact I felt it was impossible to have a balanced discussion on here primarily due to the antics of one poster.
I was not the only one and in fact you yourself ventured onto there for a while before coming back here.
I like anyone else am free to post on any board where they are a member and I can comment on any individual if merited equally which is everyone’s prerogative.
I do make occasional comments but normally only targeted at one individual and sometimes in response to personal attacks on myself.
My opinion of that individual which is in line with many others is the polar opposite of the esteem he is held by several on here. We just disagree.There are many examples in history where some are classed as hero’s but others consider them zeros.
I constantly seek to draw a line under the past but a few on here feel it necessary to trawl other boards to drag up and criticise my post calling someone a clown but happily ignore calling out that said persons use of words like “ nut job” and racist language.
So if you don’t like what I say just filter me but I do find the hypocrisy on here astounding.
Hi C7,
There are a few who have a deep seated agenda (AKA hatred) and use both BB's to their advantage, little man syndrome IMO.
Just ignore it, not worthy of expending any brain power on it, too may variables, unless you have other powers like mind reading.
ATB
Bunsie
Evening C7,
You have ventured to the "dark side"? hope it's not contagious, don't want it over here do we!
Best regards to you
ATB
Bunsie
Very interesting discussion about this important issue. I hope that this boosts us up the queue for consideration.
Fair assumption Ivy, would be good if that is the case.
Just a little word, I have just started reading some of the posts on ADVFN, it was choice that kept me away from that BB purely because of the vivious posting that took place over the years.
I feel now there is a handful of posters whose opinions are worth hearing, I saw your posts about this BB earlier in the week on ADVFN and will refrain from posting another derogatory post aimed at this BB by you (was it today?).
Wouldn"t it just be better for anyone to refrain from posting insulting comments about either BB, as adhered by this BB for some time, and considering so many of your posts were aimed at bullying etc............why make repeated disparaging remarks over there, but continue to post here?? Seems unnecessary to me, all opinions are good, as you say, so why do it???,
especially at a time we can all benefit from events unravelling here, on both BBs in harmony for a change.