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For those that were under the opinion that Sareum had missed the boat.
https://www.msn.com/en-gb/news/world/covid-strain-that-contains-18-mutations-is-more-deadly-and-infectious/ar-BB1gwECo?ocid=msedgdhp
Hello Stoney40.
Yes HOG seems ok and much better than witty old git haha.
However bad we may feel at times, there will always be someone, somewhere, far worse off than us.
Regards.
latest here with regards to latest strain of Covid 19. For the fools that think it is over and the ignorant that think they are immune from it all.
ttps://weather.com/en-IN/india/coronavirus/news/2021-05-08-indias-b1617-coronavirus-variant-can-evading-antibodies
Regards
Good morning Stoney40. Interesting abstract from the patent application/granting :-
'Accordingly, in further aspects, the invention provides:
2.8 A method of treating a disease or condition in a subject in need thereof, wherein the disease is selected from an inflammatory disease or condition, an immunological disease or condition, an allergic disease or disorder, a transplant rejection and Graft-versus host disease, or a disease or condition selected from sepsis and septic shock, wherein the disease or condition is susceptible to TYK2 inhibition, which method comprises administering to the subject an effective TYK2 inhibiting amount of a compound of the formula (0), (1) or (2) or a salt thereof as defined in any one of Embodiments 1.0 to 1.105.
2.9 A compound of the formula (0), (1) or (2), or a salt thereof, as defined in any one of Embodiments 1.0 to 1.105 for use in the treatment of an inflammatory disease or condition, an immunological disease or condition, an allergic disease or disorder, a transplant rejection and Graft-versus host disease; or for use in the treatment of sepsis or septic shock, wherein the disease or condition is susceptible to TYK2 inhibition.
2.10 The use of a compound of the formula (0), (1) or (2), or a salt thereof, as defined in any one of Embodiments 1.0 to 1.105 for the manufacture of a medicament for the treatment of an inflammatory disease or condition, an immunological disease or condition, an allergic disease or disorder, a transplant rejection and Graft-versus host disease; or for use in the treatment of sepsis or septic shock, wherein the disease or condition is susceptible to TYK2 inhibition.'
As Thoth correctly pointed out over 50% of illnesses and diseases are due to our immuno systems.
Doors will be coming off soon.
Regards all.
Generic manufacturing of any seriously effective drug seems to be where the majority of poorer nations will go.
https://www.google.co.uk/amp/s/m.timesofindia.com/business/india-business/natco-rolls-out-baricitinib-ahead-of-approval-for-patent-waiver/amp_articleshow/82442841.cms
Yes it does seem ridiculous, however, put in the context of NYCT last year which peaked at over £12 in covid. They had supplied consumables for the crisis. In comparison, we have a potential therapeutic that can be used to treat the immune over reaction and take the strain off ICUs and bring the world economy back on track. Seriously, how much is that worth.......????
On top of this, it may also treat many other bacterial conditions from other virus attacks causing pneumonia.
The signs are already positive from the board, with Parker’s ‘major development’ tweet, the news from the half year results ‘encouraging results’ and ‘continued success’. Then as SOG says, we still have all the original autoimmune and cancer treatments that our TYK2s were designed for.
Stand by and strap in team.
GLA
Great post SOG
I think you should change your name to HOG - HAPPY OLD GIT
Good luck pal
Bang on Sad, as working mentioned we will have the biggest herd we've ever seen arrive here- as we have seen in AIM the pump will propell the price way over 50p possibly into £ territory.
A lot of millionnaires will be made some twice or thrice over and Sareum will be a billion £ company as Thoth has shown and RMM in the past the figures are truly amazing but very very real.
And the best part- Sareum are not a covid play we have as you mentioned 1802 cancer no tox, no mtd, studied by the US army, worldwide patented, almost ph1 ready and no competition in the Tyk2 cancer space. 1801 going into ph1 auto-immune and chk1 can go ph3, anogenital orphan fast-track and other combo therapies as some inc. Cancer research shown. And of course on standby Aurora which is still good and has not failed.
Well put sadoldgit ....
I have taken the biggest confidence from the two scientists. These guys are nerds and not into ramping as we have seen. They are now as ahfam said using language that sayscwink wink, but till it goes into humans then we are still waiting.
I am very confident on covid19 and the fact patent and further indications, gives confidence.
Yes Thoth, the mind truly boggles. 2 billion dollars a year Remsdisivir just in the USA, for a drug that has the dreaded NDA black box warnings ie adverse toxicity and adverse side effects associated with it and only now allowed for use in emergency situations.
A good post from you Ahfam, top notch.
My thoughts, way of thinking or whatever you chose to call it leads me to add the following:-
If. and when 1801 gets it chance to be trialled and if found successful in any way shape or form for Covid alone would turn Sareum into a billion pound company overnight at least. If we take it also to be used in many other applications and also future flu pandemics ( (this will not be the last) after this one, plus its potential in all other immunotherapies then it indeed truly will be mind boggling. Of course there is also 1802 on top of that.
At the moment i see ( correct me if you have anything to the contrary) absolutely no competition from any other pharma or any other product which they manufacture has the potential of the Tyk 2 compound for the treatment of Covid. Toxicity and side affects being paramount problems as we well know.
Vaccines will work up to a point and there is not one which is 100% successful ( never will be), as we have seen some of the Covid 19 mutations are developing a resistance to them and hence have limited effect.. Always will be a case of playing to catch up. Over 7 billion people on the planet and under 160 million tested positive, Divide 160,000 by 7,000,000,000 and multiply by a hundred gives us just under 3% of known cases in the world population. sooner or later all 7 billion in whatever shape or form will be exposed to the virus along with the Covid mutations.
As I recall Tyk2 had no adverse affects at 30 times treatment dosage. The dosage was increased way beyond this to such an extent that the compound had to be reformulated to establish a maximum tolerated dose. This point I will stress again as one of the most important aspects of our compound.
Tyk 2 1801 is not an answer all on its own, vaccines will need be required as will the wearing of masks for some time yet. If and when this pandemic finishes, Tyk2 will still be a strong compound for treatments for the purposes it was invented and tested for.
Call me want you want, but I am not ramping, just confident.
Regards
And im happy with 28p (am happy where the sp is now to be honest).
But remdesivir as a covid therapeutic not really effective. Its notching profits of 2bn this year just in the USA just in hospitals. Pe ratio pharma is 85. Thats 160bn mcap. Add in non usa market. Non hospitals. Once daily pill. Not saying it will. Doubt it will. But **** me sideways if it does. Boggling