Block Listing Six Monthly Return

Name of applicant:

ALLIANCE PHARMA PLC

Names of schemes:

a) The Alliance Pharma plc Approved Share Option Plan 2005

b) The Alliance Pharma plc Share Option Plan 2006

c) The Alliance Pharma plc Company Share Option Plan 2015

Period of return:

From:

28 June 2018

To:

28 December 2018

Number of securities originally admitted at date of admission:

25,000,000 ordinary shares of 1p each

28 June 2017

Balance of unallotted securities under schemes from previous return:

a) 1,466,103

b) 17,416,041

c) 2,795,812

Plus: The amount by which the block schemes have been increased since the date of the last return (if any increase has been applied for):

a) Nil

b) Nil

c) Nil

Less: Number of securities issued/allotted under schemes during period:

a) 374,837

b) 2,070,353

c) 745,890

Equals: Balance under schemes not yet issued/allotted at end of period:

a) 1,091,266

b) 15,345,688

c) 2,049,922

Name of contact:

Chris Chrysanthou, Company Secretary

Telephone number of contact:

Tel. +44 (0)1249 705166