SLN.L Regulatory News (SLN)

NOTIFICATION OF MAJOR HOLDINGS (to be sent to the relevant issuer and to the FCA in Microsoft Word format if possible) i

1a. Identity of the issuer or the underlying issuer

of existing shares to which voting rights are

attached ii:

Silence Therapeutics plc

1b. Please indicate if the issuer is a non-UK issuer (please mark with an "X" if appropriate)

Non-UK issuer

2. Reason for the notification (please mark the appropriate box or boxes with an "X")

An acquisition or disposal of voting rights

x

An acquisition or disposal of financial instruments

An event changing the breakdown of voting rights

Other (please specify) iii:

3. Details of person subject to the notification obligation iv

Name

LOIM Lombard Odier Asset Management (Europe) Limited

City and country of registered office (if applicable)

London, United Kingdom

4. Full name of shareholder(s) (if different from 3.) v

Name

City and country of registered office (if applicable)

5. Date on which the threshold was crossed or reached vi:

25/10/2021

6. Date on which issuer notified (DD/MM/YYYY):

26/10/2021

7. Total positions of person(s) subject to the notification obligation

% of voting rights attached to shares (total of 8. A)

% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)

Total of both in % (8.A + 8.B)

Total number of voting rights of issuer vii

Resulting situation on the date on which threshold was crossed or reached

8.84%

2.17%

11.01%

89,777,000

Position of previous notification (if applicable)

5.94%

4.20%

10.14%

8. Notified details of the resulting situation on the date on which the threshold was crossed or reached viii

A: Voting rights attached to shares

Class/type of

shares

ISIN CODE (if possible)

Number of voting rights ix

% of voting rights

Indirect(Art 10 of Directive 2004/109/EC) (DTR5.2.1)

Direct(Art 9 of Directive 2004/109/EC) (DTR5.1)

Indirect(Art 10 of Directive 2004/109/EC) (DTR5.2.1)

GB00B9GTXM62 Ordinary

7,935,940

8.84%

SUBTOTAL 8. A

7,935,940

8.84%

B 1: Financial Instruments according to Art. 13(1)(a) of Directive 2004/109/EC (DTR5.3.1.1 (a))

Type of financial

instrument

Expiration

date x

Exercise/

Conversion Period xi

Number of voting rights

that may be acquired if

the instrument is

exercised/converted.

% of voting rights

ADR US82686Q1013

1,951,032

2.17%

SUBTOTAL 8. B 1

1,951,032

2.17%

B 2: Financial Instruments with similar economic effect according to Art. 13(1)(b) of Directive 2004/109/EC (DTR5.3.1.1 (b))

Type of financial instrument

Expiration date x

Exercise/

Conversion Period xi

Physical or cash settlement xii

Number of voting rights

% of voting rights

CASH

SUBTOTAL 8.B.2

9. Information in relation to the person subject to the notification obligation (please mark the

applicable box with an "X")

Person subject to the notification obligation is not controlled by any natural person or legal entity and does not control any other undertaking(s) holding directly or indirectly an interest in the (underlying) issuer xiii

x

Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entity xiv (please add additional rows as necessary)

Name xv

% of voting rights if it equals or is higher than the notifiable threshold

% of voting rights through financial instruments if it equals or is higher than the notifiable threshold

Total of both if it equals or is higher than the notifiable threshold

10. In case of proxy voting, please identify:

Name of the proxy holder

The number and % of voting rights held

The date until which the voting rights will be held

11. Additional information xvi

Place of completion

London

Date of completion

26/10/2021