Sant Uk.8fepf Regulatory News (SANB)

SANTANDER UK PLC

€30 BILLION EURO MEDIUM TERM NOTE PROGRAMME

PUBLICATION OF FINAL TERMS - SERIES B-1486

The following final terms (the Final Terms) are available for viewing:

Issue of EUR 750,000,000 Senior Floating Rate Notes due 2028 (ISIN XS3032031257) (Series B-1486) (the Notes) by Santander UK plc, under the €30 billion Euro Medium Term Note programme of Santander UK Group Holdings plc and Santander UK plc (the Programme).

To view the full Final Terms document, please click on or paste the following URL into the address bar of your browser:

http://www.rns-pdf.londonstockexchange.com/rns/0606C_1-2025-3-25.pdf

A copy of the Final Terms has been submitted to the National Storage Mechanism and will shortly be available for inspection at: https://data.fca.org.uk/#/nsm/nationalstoragemechanism. This website is not provided for, nor is it directed at, U.S. persons or persons in the United States. If you are a U.S. person, or you are viewing this page from the United States, you should exit this section of the website.

For further information, please contact:

Funding, Asset Rotation and Investor RelationsSantander UK plc2 Triton SquareRegent's PlaceLondon NW1 3AN

Email: mtf@santander.co.uk

DISCLAIMER - INTENDED ADDRESSEES

Please note that the information contained in the Final Terms and the Prospectus published in respect of the Programme on 5 April 2024, as supplemented on 30 April 2024, 24 July 2024, 9 August 2024, 20 November 2024, 5 February 2025 and 7 March 2025 (together, the Prospectus) may be addressed to and/or targeted at persons who are residents of particular countries only (as further specified in the Prospectus) and is not intended for use and should not be relied upon by any person outside these countries and/or to whom the offer contained in the Final Terms and the Prospectus is not addressed. Prior to relying on the information contained in the Final Terms and the Prospectus you must ascertain from the Final Terms and the Prospectus whether or not you are part of the intended addressees of the information contained therein.

Your right to access this service is conditional upon your compliance with the above requirement.

This publication of the Final Terms does not constitute an offer of securities for sale in the United States. The securities described herein have not been, and will not be, registered under the U.S. Securities Act of 1933, as amended (the Securities Act), or under any relevant securities laws of any state of the United States of America, and may not be offered or sold in the United States of America or to, or for the benefit of, U.S. persons (as defined in Regulation S of the Securities Act), unless the securities are registered under the Securities Act or an exemption from the registration requirements of the Securities Act is available.