Proteome Regulatory News (PRM)

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Sciences plc

2. Reason for notification (yes/no)

An acquisition or disposal of voting rights

Yes

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached 

An event changing the breakdown of voting rights

Other (please specify):______________

3. Full name of person(s) subject to the notification obligation:

Cubana Investments Limited

4. Full name of shareholder(s) (if different from 3.):

5. Date of the transaction (and date on which the threshold is crossed or reached if different):

10 October 2008

6. Date on which issuer notified:

13 October 2008

7. Threshold(s) that is/are crossed or reached:

9.00%

8. Notified details:

A: Voting rights attached to shares

Class/type of shares 

 if possible using the ISIN CODE

Situation previous to the Triggering transaction 

Resulting situation after the triggering transaction

Number of Shares 

Number of Voting Rights 

Number of shares 

Number of voting rights

% of voting rights

Direct

Indirect 

Direct

Indirect

GB003104196

10,987,468

10,987,468

11,987,468

11,987,468

9.03%

B: Financial Instruments

Resulting situation after the triggering transaction 

Type of financial instrument 

Expiration date 

Exercise/ Conversion Period/ Date 

Number of voting rights that may be acquired if the instrument is exercised/ converted. 

% of voting rights

Total (A+B)

Number of voting rights

% of voting rights

11,987,468

9.03%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14. Contact name:

James Malthouse

15. Contact telephone number:

+44 1932 865065

Annex: Notification of major interests in shares

A: Identity of the persons or legal entity subject to the notification obligation

Full name 

(including legal form of legal entities)

Cubana Investments Limited

Contact address 

(registered office for legal entities)

PO Box 957, Offshore Incorporations Centre, Road Town, Tortola, British Virgin Islands

Other useful information 

(at least legal representative for legal persons)

B: Identity of the notifier, if applicable

Full name

Mirza Rahman

Contact address

2 Battery Road, #26-01 Maybank Tower, Singapore 049907

Phone number & email

+ 65 6538 1998 : msrahman@artradis.com

Other useful information

(e.g. functional relationship with the person or legal entity subject to the notification obligation)

Compliance Officer

C: Additional information