Proteome Regulatory News (PRM)

26 Feb 2009 09:00

For filings with the FSA include the annex For filings with issuer exclude the annex TR-1: Notifications of Major Interests in Shares 1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: Proteome Sciences plc 2. Reason for notification [Yes/No] An acquisition or disposal of voting rights Yes An acquisition or disposal of financial instruments which No may result in the acquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights No Other (please specify): No

3. Full name of person(s) subject to Sanofi-Aventis Deutschland GmbH notification

obligation: 4. Full name of shareholder(s) (if different from 3): 5. Date of transaction (and date on 24 February 2009 which the threshold is crossed or reached if different): 6. Date on which issuer notified: 25 February 2009 7. Threshold(s) that is/are crossed or 9.00% reached: 8: Notified Details A: Voting rights attached to shares Class/type of Situation previous to Resulting situation after shares the triggering the triggering transaction transaction If possible Number of Number of Number of Number of Percentage of use shares voting shares voting rights voting rights ISIN code rights Direct Indirect Direct Indirect GB003104196 13,663,380 13,663,380 12,286,187 12,286,187 9.25% B: Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ No. of voting Percentage of financial date conversion rights that may be voting rights instrument period/date acquired (if the instrument exercised/ converted) Total (A+B) Number of voting rights Percentage of voting rights 12,286,187 9.25%

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

Proxy Voting: 10. Name of proxy holder: 11. Number of voting rights proxy holder will cease to hold: 12. Date on which proxy holder will cease to hold voting rights: 13. Additional information: 14 Contact name: James Malthouse 15. Contact telephone name: +44 1932 865065