Proteome Regulatory News (PRM)

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Sciences plc

2. Reason for notification (yes/no)

An acquisition or disposal of voting rights

Yes

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify):______________

3. Full name of person(s) subject to notification obligation:

Cubana Investments Limited

4. Full name of shareholder(s) (if different from 3):

5. Date of transaction (and date on which the threshold is crossed or reached if different):

29 January 2010

6. Date on which issuer notified:

1 February 2010

7. Threshold(s) that is/are crossed or reached:

>12%

8: Notified Details

A: Voting rights attached to shares

Class/type of shares

If possible use ISIN code

GB0003104196

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of shares

15,187,465

Number of voting rights

15,187,465

Number of shares

16,193,355

Number of voting rights

Percentage of voting rights

Direct

16,193,355

Indirect

16,193,355

Direct

12.19%

Indirect

12.19%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ conversion period/date

No. of voting rights that may be acquired (if the instrument exercised/converted)

Percentage of voting rights

Total (A+B)

Number of voting rights

Percentage of voting rights

16,187,465

12.19%

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

Proxy Voting:

10. Name of proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14 Contact name:

James Malthouse

15. Contact telephone name:

+44 1932 865065

Annex: Notification of major interests in shares

A: Identity of the persons or legal entity subject to the notification obligation

Full name

(including legal form of legal entities)

Cubana Investments Limited

Contact address

(registered office for legal entities)

PO Box 957, Offshore Incorporations Centre, Road Town, Tortola, British Virgin Islands

Other useful information

(at least legal representative for legal persons)

B: Identity of the notifier, if applicable

Full name

Andy Ng

Contact address

59 Club Street, 2nd Floor, Singapore 069 434

Phone number & email

+65 6538 1998 : andy.ng@gfia.com.sg

Other useful information

(e.g. functional relationship with the person or legal entity subject to the notification obligation)

Compliance Officer

C: Additional information