ETX.L Regulatory News (ETX)

e-Therapeutics plc("e-Therapeutics" or the "Company")

Notification of Transactions of Directors, Persons Discharging Managerial Responsibility or Connected Persons

The Company was informed on the 3 March 2011 that Steve Self, an Executive Director, purchased on the 3 March 2011 50,000 ordinary shares at 36.5p per share. His resultant total holding is 86,413 shares representing 0.12% of the issued share capital of the company.

4 March 2011.

For more information, please contact:

e-Therapeutics plc

Malcolm Young / John Cordiner

Tel: +44 (0) 191 233 1317

E-mail: malcolm@etherapeutics.co.uk

www.etherapeutics.co.uk

Panmure Gordon (UK) Limited

Andrew Burnett / Aubrey Powell

Tel: +44 (0) 20 7459 3600

www.panmuregordon.com