Pirepemat stumbles in Phase IIb study

IRLAB has announced top-line results for its Phase IIb trial assessing pirepemat’s potential to improve balance and reduce falls in Parkinson’s disease (PD-Falls). The primary endpoint was the change in patients’ fall rates, and while the high-dose 600mg group showed a 42% reduction, the effect was not statistically significant compared to placebo. A meaningful improvement in cognitive impairment was also observed in the 600mg group, although this did not achieve statistical significance either. IRLAB will conduct a detailed review of the study data before making a decision on next steps for the programme. Reflecting the increased uncertainty, and pending release of the full data set, we have reduced our probability of success (PoS) for...