Roundtable Discussion; The Future of Mineral Sands. Watch the video here.
I would respectfully suggest that given the passage of time, and the number of sensible and reasoned responders who have replied to certain individuals over this considerable period, that these 'certain individuals' are not just misguided or unsure, they are simply seeking to bait others and, unfortunately, they are getting their way. Solution - use the filter provided and save those who have used this service from having to see the responses that are clearly not having their intended result. Silence also works wonders.
"Researchers from the Our Future Health programme are calling on 5m UK adults to join what is hoped to be one of the biggest studies in the world. Part-funded by the government, industry and charities, the programme is looking to create the most detailed picture of a nation’s health ever. It aims to find more efficient ways of preventing, spotting and treating illnesses such as cancer and dementia early on." (25.10.22)
https://email.sheerluxe.com/q/1eWdsph3Qo2P1mRz6CKBCi7/wv
If only a fraction of the 'called up' 5m were to get Covid/other Resp. illness and could be dosed with SNG, could that be a ready made PT group right there?
.. probably isn't worth the time and effort here relative to the short presentation which (imho) is just the foot in the door. The opportunities, are over the days of the conference with networking and rubbing shoulders with the BP's, trial organisers, investigators, et al. We won't know any of that anyway, so it's sit back, relax, and save your blood pressure.
Well said The P ...
Certainly got the big guns out today ...
"2:35 PM – 2:45 PM US ETLB1533 - Impact of Treatment of Hospitalised COVID-19 Patients With Inhaled Interferon Beta-1a (SNG001) on Long COVID Symptoms: Results From the SPRINTER trial
Location: 209 ABC
Presenting Author: Phillip D. Monk, PhD – Synairgen Research Limited
Co-Author: Rachael A. Evans, PhD FRCP – University of Leicester
Co-Author: Victoria J. Tear, PhD – Synairgen Research Limited
Co-Author: Jody L. Brookes, BSc – Synairgen Research Ltd
Co-Author: Toby Batten, MSc Statistics with Applications in Medicine – Veramed Ltd
Co-Author: Marcin Mankowski, MD, MFPM (Dis) – tranScrip Ltd
Co-Author: Ratko Djukanovic, MD – Faculty of Medicine, University of Southampton
Co-Author: Stephen T. Holgate, FMedSci, MD – University of Southampton
Co-Author: chris brightling, FMedSci – University of Leicester
Co-Author: Tom Wilkinson, PhD, PhD – University of Southampton"
Whilst we wait and hope that SNG's Dr. M will add more fuel to the SNG fire this week, I can only suspect that something else is having an effect (albeit conservative so far) on the SP. I can only further guess that Poly (TFG) are moving ever closer to 29.9%.
Did Poly really, "get it wrong" back in Feb?
Could it not just be that (in their world - not ours) it was just another calculated risk they were happy to 'ride' given their due diligence (no doubt at a higher level than ours) and, if so, they would know that the upside to a P3 fail was the opportunity for them to buy more far lower than otherwise would be the case ... exactly as they have done ?
There's always two ways of looking at something. Bottom line - we don't know, but I would suggest more likely than them not having considered it at all. I suspect they just moved along with their plan regardless without the hand-wringing and hair-pulling we went through.
Nice one Tommy - my favourite part is this ...
"The RECOVER initiative’s wide scope of research is also unprecedented. It is needed because Long COVID is so complex, and history indicates that similar post infectious conditions have defied definitive explanation or effective treatment. Indeed, those experiencing Long COVID report varying symptoms, making it highly unlikely that a single therapy will work for everyone, underscoring the need to pursue multiple therapeutic strategies."
Further to my previous post suggesting caution, I would endorse Mani's suggestion that if any overt action was to be taken why not simply run it by SNG too ask if this would help ... or hinder. Why risk doing anything that may simply fall flat. Clearly the SNG will be doing all that they believe is required so it is actually quite hard (at least for me) to believe there is anything for us to do, but, if there is, then great. Given the potential politics involved (as per Titania's post) there may well be some very delicate discussions either on-going, or about to commence. All credit to the suggestion to help, but it has to fit in with the big picture which surely, none of us are privy to.
As PI's there's nothing to stop anyone doing anything to try and promote their investment. I would always promote +ve action where relevant.
However ... my only fear (albeit maybe irrational) is that, as we approach what is hopefully the final stage of realising success, e.g. when somehing is getting to the 'tickly stage' .. my reaction before jumping in is to consider, 'is there something going on behind the scenes that I don't know which might make even the most well-intentioned action have a -ve effect?'
Just adding a slight note of caution, that perhaps a word in SNG's ear may not be a bad idea ?
I think its fair to say no-one is unhappy that Poly (TFG) are on board, and continuing to buy. It's seems fair to say they were, like us waiting for the expected milestones/news and acted accordingly to whatever their plan is. Pontificating about what they knew/suspected in January does seem a little pointless, but to think they are as much in dark or caught out as we were does seem unreasonable with the £m's they had invested and that they do this for a living rather than armchair investors (albeit many on here clearly have good knowledge and research skills). To 'go with what we (actually) know' seems more sensible to me and that's the fact that they have added gain following A2P2. I'm no investing/financial expert by any stretch of the imagination but that means I have to rely on the facts ... however few 'drops' they may be compared to the 'ocean' of speculation. If I do attempt a guess, it would be that Feb 21st was just one of a number of risks that Poly (TFG) had up on the board calculated by likelihood x impact. They probably were less surprised than we were. But as I say, it is their actions now that clearly matter, regardless. GLA.
Shared from Twitter ...
https://twitter.com/ITNBusiness/status/1577332078093508609?t=W6uEpa90kwkJ0kkPF8K6Kw&s=19
I particularly like the additional comment from William Fischer, M.D., University of North Carolina (UNC), lead investigator of SNG001, which highlights the very unique nature of the drug and its delivery method.
" .... SNG001 is the first nebulized inhaled therapeutic to demonstrate promising results and, if confirmed in larger studies, could represent a potential treatment option for people who have COVID-19 but are not hospitalised."
Add to that the body of work by SNG over the last 15+ years, their scientific credentials and integrity with the growing body of evidence & corroborative data that has been stepping up with more peer review and A2P2 deep dive yet to come. We must be well-placed on BP radar, where there are deep pockets and eye towards acquisition, when gov'ts are likely to have £b's to spend on safe, broad spectrum products for current use as well as future stock-piling. No big eureka moment here, but more likely to be a steady build-up of good data that reaches a de-risk tipping point.
"Southampton's Synairgen set to announce positive clinical trial results for long Covid treatment"
https://businessmag.co.uk/companies/southamptons-synairgen-set-to-announce-positive-clinical-trial-results-for-long-covid-treatment/
TP ... thanks for the 'nature' article' as the upcoming Seattle trial relates exactly to my son's symptoms which started after the first AZ vaccine shot.
Just incase this helps anyone else I'll expand a little (otherwise no need to read on) ...
After nearly 2 years of hospital visits he found a Consultant (thanks to his employer's health scheme) who took a real personal interest to stop the hospital visits 'merry-go-round' he was on. He referred him to a Doctor friend & colleague specialising in headaches etc which got him onto a defined path to eliminate causes etc. It seems at 6' 5", his young age and extreme level of fitness (former National squad basketball player) was a factor in wanting to get to the bottom of his symptoms. He's had CT scans, MRI's, and numerous bloods taken, with all throwing up nothing and a lumber puncture looms. Getting the right medical person seems to be so important with so many different people reporting widely varying symptoms.
Thanks again ... this shows the benefits of sharing info on this BB to help each other.