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Hi Qd and share D,
To contact Clinigen to be added to the MAP, Get your GP or Hospital contact to got to...
Healthcare professionals in the EU can obtain details about the SNG001 Managed Access Programby calling the customer service team at +44 (0) 1283 494 340 or emailing medicineaccess@clinigengroup.com.
pmjh, did you see this one posting twice as I think its pivotal
This does not bode well for people in the winter flu season, treatments will be needed urgently. Below is an extract from a CO-CIN* SAGE rapid report 23/9/2020. The link is also attached to support the extracts from p2 and p5.
"Interpretation and policy implication"
"In the context of the SARS-CoV-2 pandemic and winter flu season, co-infection is likely to place additional strain on hospital capacity and resources.
Great efforts should be made to encourage widespread influenza vaccination, ideally extending beyond traditional high-risk groups for severe influenza to the newly identified risk groups for severe covid-19 in the UK (Docherty AB et al. BMJ 2020).
Further research is required to understand
1: the effects of influenza plus covid-19 on outcomes and
2: plan for the likely consequences of the additional burden placed on healthcare facilities if significant numbers of patients have concurrent influenza and SARS-CoV- 2 infection."(Page2)
"Outcomes of patients who were tested for influenza
Patients who tested positive for influenza at any point in their hospital stay were more likely to be admitted to critical care, receive invasive ventilation and had nearly twice the length of stay. Death was similar across the testing groups. Patients who tested positive for flu had a significantly longer length of stay (over twice as long) than those who tested negative for flu."(Page 5)
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/921524/S0774_Influenza_infection_in_patients_hospitalised_with_COVID-19.pdf
FYI COVID-19 Clinical Information Network (CO-CIN)
*CO-CIN collates clinical information from the usual health care records of people of all ages admitted to hospital in the UK to characterise the clinical features of patients with severe COVID-19 in the UK.
Apologies if this has been posted, was doing some catch up "R" excellent reading re the overall business model.
https://www.clinigengroup.com/media/2115/clinigen-full-year-results-17sep2020-presentation.pdf
Agree, there are solid foundations going in here, market expansion and scale up
...
it is now 53 min after my allowable beer time, just about to open, the first, a cold Goose Midway session IPA, this is not a recommendation or ramp but an action by me :)
Hi RTNB,thanks I see where you come from, From my experience, I reckon they would not manufacture unless a firm order is in the books to underwrite this scale up. How much that is not known to me.
Its the word "ordered" and "winter" and "second wave "that pushes my chat here.
Hi Bella and all
I just posted this on the "long thread" which may help support the 100,000 etc, I am sure you have seen it but it needs reminding IMHO , Agree the manufacturing/licence/acquisition partner is key to this for further scale up.
Guardian 24/7/2020
" Synairgen has already ordered the drug manufacturer Rentschler to start producing supplies, with the aim of getting more than a million doses ready for a possible second wave of coronavirus in the winter.
Reminder,
The Guardian (see below,earlier )did report that SNG had placed an order with Rentschler to manufacture enough for 1 million doses this is still excellent news and part of the scale up process, this should done as fast and as safely as possible.
Vectura, Rentschler et al all need time to scale their processes, to ensure the product manufactured is safe for its intended use. With todays announcement opening up the EU market with Clinigen makes me confident the product is being tirelessly worked as fast as possible. Its in the date 24/7 ;)
Guardian 24/7/2020
" Synairgen has already ordered the drug manufacturer Rentschler to start producing supplies, with the aim of getting more than a million doses ready for a possible second wave of coronavirus in the winter.
Bella , This is huge,
Also my flu a flu vaccine request came in this week, do I get one is my current dilemma,
Googled, that great medic in the sky..and found-
2019/2020 45% effective spending on the stats and strains you read about.. thats 55% not effective
Great post,Robort,
To add folks I posted earlier but worth a bump..
The real value for patients and investors here is the BROAD efficacy of SNG001
Read this very carefully as its very exciting
Very much worth a re- read especially the 2nd last sentence of the paragraph from rNS 8/9/2020, below, this gives me huge confidence in the potential applications of SNG001.
"SNG001 has demonstrated antiviral activity against multiple viruses in cell-based assays. "
"•
Virology
A range of common respiratory viruses including rhinovirus, influenza, adenovirus, respiratory syncytial virus (RSV), human metapneumovirus (HMPV), parainfluenza and coronavirus (the four strains that cause common cold symptoms, but not SARS-
CoV-2, the virus that causes COVID-19) were identified in nasopharyngeal and/or sputum samples from the COPD patients in this trial. This is relevant because COVID- 19 patients can be coinfected with other respiratory viruses such as influenza. SNG001 has demonstrated antiviral activity against multiple viruses in cell-based assays. Further virology work is being conducted."
Holding 100% my heart rate is good. BP good, don't ask me about my beer intake after 5pm though ;)
Thanks for the response DPunt, I don't disagree with you re detail allowed, but they should communicate what they can on it, as former Board Marketeer with the Huge and tiny Med Device Companies, I used to be astounded at the lack of Marketing and Sales Strategies or if they had one their lack of implementation. Sometimes excellent products were "best kept secrets"as not enough noise was being made in the early days. The "Proactive "video today is a great step forward again.
Overall I am confident and Holding all,
Extract from mid term update RNS today,
"The Company is also investing in supply chain activities to ensure that drug and aerosol delivery system availability can meet potential demand, pending approval"
Overall I think the Clinigen partnership is a solid step forward and is a broad pre-market entry. However a timely RNS on the actual production/ commercialisation/distribution/marketing and launch strategy would further increase the high level of confidence we have in the product and sng team.
FYI ,CSC Appear to advise both SNG and Vectura, Independently for RNS etc, two from Vectura today on Shares and a Board resignation. WTT
Apologies if someone posted previously,
IMHO I think the Patient groups, Political (all sides), Medical and Scientific community would come out in the droves if they thought an excellent treatment such as SNG001 was being held back or buried. My guess/gut feel is that its an NDA and Due Process to verify the claims are the root. Then concomitantly (I hope) they are ramping (positive use ;)) up from Trials, Regs , QA, to Manufacture and distribution etc etc, which all take a bit of time.
I trust that the leading runner, with SNG001 on the vest, is now turning the corner in to the final straight, no looking back, the finishing line is in sight.
Very relaxing Hold4
Everton,
To be fair this was done during my first glass, creativity diminishes after the 2nd enjoy the WE
Shiny apple story
Apologies folks but I like an unconventional take sometimes...
We are in Autumn and the last of the harvesting is about to take place on a high grade premium, "short" supply crop with a lot of interested parties for only 149 million shiny apples, The faRMer will sell to the best partner when the crop is verified, Each day a few shiny apples are taken out of a sMMall box and lose a little shine, but every day, deep down, the shiny apples stay the same and smile knowing they are worth more than that. These sMMall box apples go red when the tree shakes and can lose a little shine but they are all Green or even Blue on the inside. My apples have asked me to hold.
NICE ONE SYNGOLD ! Fair brightened the day, its P''''n down here
Original was by Abba SOS...
Where are those happy days, they seem so hard to find
I try to reach for you but you have closed your mind
Whatever happened to our love? I wish I understood
It used to be so nice, it used to be so good
So when you're near me, darling can't you hear me, R.N.S
The love you gave me, nothing else can save me, R.N.S
When you're gone
How can I even try to go on?
When you're gone
Though I try, how can I carry on?
You seemed so far away, though you were standing near
You made me feel alive but something died, I fear
I really tried to make it up, I wish I understood
What happened to our love, it used to be so good
So when you're near me, darling can't you hear me, R.N.S
The love you gave me, nothing else can save me, R.N.S
When you're gone
How can I even try to…