Roundtable Discussion; The Future of Mineral Sands. Watch the video here.
The interesting and somewhat scary read from this is most people are now vaccinated to some degree and yet a 40% increase in ICU
New treatments and less are dying but if you end up in ICU the long term consequences to your health and the ongoing cost to the health system or insurance can be vast.
“During the period from 11 December 2023 to 7 January 2024, COVID-19 new hospitalizations and admissions to an intensive care unit (ICU) both recorded an overall increase of 40% and 13% with over 173 000 and 1900 admissions, respectively”
Accelerated immune ageing is associated with COVID-19 disease severity
Doesn’t bode well for us as we get older
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10782727/
“Whether or not this enhanced immunesenescence ( the state of dysregulated immune function that contributes to the increased susceptibility of the elderly to infection and possibly to autoimmune disease) is a result or consequence of COVID-19, it does suggest that these patients will be more vulnerable to future infections, show compromised vaccine responses and be at a higher risk of autoimmune disease. Moreover, as the induction of an aged immune system, specifically senescent CD4 T cells, has been shown in mice to be sufficient to drive an aged phenotype, including frailty and multimorbidity [46], our data may also suggest broader implications for the health of COVID-19 survivors. Evidence from recent studies has suggested the persistence of a spectrum of COVID-19 symptoms for up to 12 months after diagnosis, termed Long COVID, including persistent fatigue, myalgia and respiratory complications [47, 48]. Studies of COVID-19 convalescents 3–5 months post-infection have revealed maintained high levels of IL-6 associated with persistence of symptoms [4] and a study of autoantibody levels in serum found a high frequency of antibodies against the skin, skeletal muscle and cardiac tissue [5]. The aged immune system may thus contribute to both the acute and chronic sequelae of COVID-19”
WHO stats
Globally, the number of new cases increased by 4% during the 28-day period of 11 December 2023 to 7 January 2024 as compared to the previous 28-day period, with over 1.1 million new cases. The number of new deaths decreased by 26% as compared to the previous 28-day period, with 8700 new fatalities reported. As of 7 January 2024, over 774 million confirmed cases and over seven million deaths have been reported globally.
During the period from 11 December 2023 to 7 January 2024, COVID-19 new hospitalizations and admissions to an intensive care unit (ICU) both recorded an overall increase of 40% and 13% with over 173 000 and 1900 admissions, respectively.
One things stands out
“Lots of qualifications for this general population study - Paxlovid patients twice as likely to be vaccinated”
We know vaccination dramatically reduces your risk of hospitalisation. We also know that Pfizer abandoned its study of less severely acute patients because they couldn’t show a difference compared to placebo.
These retrospect studies have to be taken with a large grain of salt. As we saw with Molnupiravir which in a clinically controlled study showed no advantage compared to placebo of vaccinated patients. It’s notable that Pfizer has not gone on to run a clinical trial of vaccinated patients.
In terms of sng001 or any drug, the cost equation relates to the cost of treatment vs benefit if they hadn’t received the drug
Sanofi is a good example COPD trials but other exist
Dupixent COPD Phase 3 Trial Program
randomized, Phase 3, double-blind, Enrolling a total of 1,874 patients
Our COPD results are 109 patients
That’s roughly 3 times the size of Sprinter
How could we have run a trial of that size after Sprinter failed.
We couldn’t afford to run a trial of that size even before Sprinter
Facts are what this chat board needs not delusional posters
These are the COPD results from 2022 that Phil Monk presented in 2023
https://synairgen.ams3.digitaloceanspaces.com/IDWeek-2023-SG015-Poster-Final.pdf
As far as I’m aware Casanova do not manufacture, they’ve produced a patent for a device.
So somewhere out there is a company manufacturing a device using their patent and being authorised by the regulators for this purpose.
Casanova, if it is their patent being used will no doubt be highly interested in the outcome of the results, as they are in many immune related discoveries, but their profits will come from the licensing of this patent to a manufacturer not from Synairgen or J&J surely?
The aryl hydrocarbon receptor (AhR), is a signaling pathway with regards to inflammatory lung diseases therapeutic potential of targeting the AhR in regulating inflammation during acute and chronic respiratory diseases.
Asthma viral infections, exacerbations
To evaluate the therapeutic effect of IFN-β on virus-induced asthma exacerbations, we treated asthma exacerbation mice with IFN-β or dexamethasone (Dex)
IFN-β treatment was significantly more effective in preserving the respiratory system compliance and tissue damping and elasticity which indicates that IFN-β treatment not only has an effect on the airways, but also has a good effect of improvement on AHR caused by tissue damage
Asthma exacerbations lead to over 50,000 hospital admissions with an annual spend of £800 million on pharmaceutical costs alone. In addition, it is estimated that asthma leads to a direct cost to the NHS of £1 billion
https://www.nature.com/articles/s41467-023-44168-0
Seriously Mani you’re getting as bad as Doc D
Cut
Make it all up
Paste
We need a P3 eventually and don’t have the funds so no one has ever said we won’t eventually need to FJS d that in some way.
But we are not all screaming raise now at 5p for trials the company have already told us they can afford.
This isn’t the first time you’ve cried wolf
Get real and stop posting drivel
Doc D
There you go again with your
cut
Making things up
Paste
I’ve said what the company have said
Cut
The Company’s cash resources are sufficient to cover its plans to design and
establish data from an observational study and two investigator-led/Synairgen-
sponsored Phase 2 clinical trials, including manufacture of active and placebo
for use in these trials. Regardless of the outcome of these activities, which are
uncertain, the Company’s available resources are sufficient to cover existing
committed costs and the estimated costs of these activities until at least 30
September 2024
Paste
You really should take up a position in politics your mistruths are so believably well presented.
Thanks Aether, Doc D
I’m doing well, until a scan says otherwise but I guess that’s the world all C patients live in.
I’ve probably got more chance dying of boredom waiting for an update than dying of C
Tell us the detail Mani
How much are they needing to raise in your calculations
What are they raising to cover
How long in your view does the raise need to cover beyond H1
You must have done these calculations to convince yourself of the need for a raise and to satisfy yourself that any announcement is in-line with your views.
You must have calculated where you think the share price will be as that’s an important shareholder impact of any raise and you’re a shareholder
If you can’t tell us these basic things then all you’re doing is shouting raise, raise, raise which of course is what you did last year and as we all know there was no raise.
Hardly credible on this subject
Mani
So a raise in H1 for trials and money to run the company.
Well you keep quoting 5m for 6 months so how long does this raise need to last?
To the end of the trials
To the end of 2025?
How much do they need to raise at 5m for 6 months are we talking a year, 18 months.
5m x 2 or 3, plus the cost of the trials.
Give us the figure you’ve estimated they need?
Obviously when we all congratulate you for being right we want to be sure you are right to say the nearest 5m would seem fair
Tick tock Mani
You’ve been talking about this raise for a year now so you must have calculated
What they need it for
What period of time it’s covering finances for
How much is needed
When they need to do the raise it
Ok I’ll bite Mani
Let’s have the details
When will the fund raise be date please or by what date?
At what share price?
How much will they be raising?
If you’re going to keep posting drivel let’s have some facts from you!