In case anyone is wondering whether the market will react first thing, the first quote is up by Berenbergs, who make a price of 120/27 care of Richard Armstrong twitter.
UPDATE care of Marty McFly Twitter Additional study quoting higher ratios. Needless to say, FAP activation in healthy adult tissue should promote more ‘dox-for-your-buck’ accumulating in the TME.
It also suggests non-healthy adults with Arthritis etc. are not exempt from this treatment.
https://twitter.com/Blueberrymgmnt/status/1555630060786384897 BUMP. The 15 times as much FAP circulating mouse plasma as opposed to human has been mentioned before, but here is a post linking the finding to Prof Bach. Needless to say, if this is shown to be the case with the patients on trial, given the very high specificity of the pre|CISION linker, this could explain the relatively modest dose escalations that Avacta and the investigators have pursued. Because even a low dose is going to exceed significantly the performance seen in animal models.