Member Info for Num4

Seeing this at 7p still gets me...massive consolidation at these levels, remember the pump and dump crew at 4p,5p, 6p, 7p, looks a little bit different now.
Tempting to drop a few for England final but I think World Cup Hospitality would be a nicer touch.
Onwards and upwards, as always.

England flag with SAREUM through the middle would be a win win situation.. hahaha.

Busy board today, read a few comments about people thinking they are late to the party due to the recent rise and advising caution - whilst I understand you may be trying to prevent others making the same mistake you have obviously made in the past, as we all have, if you take more time to read and less time posting you should conclude that you aren't late.
The HNWI isn't thinking he is late, that £260k buyer isn't thinking he is late, us long terms weren't early, you are in my opinion classed as early, we were lucky to stumble upon Sareum many years ago and come to realise that this ain't no oiler or miner or no normal biotech, that knowledge came with research and watching Tim and John build this business, as you have seen we are all happy to share what we have picked up over the years in this highly complex industry, perhaps instead of casting the doubt, if your intentions are legitimate then try harder to understand the science and the position Sareum are in. Many posts and questions can be answered by realising there is more than just this BB to give you comfort in your investment.

Thanks to RMM for the valuation information.

Last point of note for tonight and it's with regard Sareum as a business. Think about this, Airbnb the largest holiday let company owns no houses, Uber the biggest taxi firm owns no taxi's, just eat the biggest takeaway company owns no takeaways...
Sareum the most successful biotech in Europe for SP gains owns no labs...

Tim had this model when Airbnb founder was probably in nappies.

The future is bright for Sareum and its shareholders.

Here's the link I referenced.
https://www.ukri.org/news/appointment-of-indro-mukerjee-as-new-ceo-of-innovate-uk/#:~:text=Appointment%20of%20Indro%20Mukerjee%20as%20new%20CEO%20of%20Innovate%20UK%20%E2%80%93%20UKRI

Mukerjee will take up the post immediately and will be tasked with transitioning Innovate UK from a grant funding body to an agency focused on driving economic growth. It will work with companies to de-risk, enable and support innovation, while unleashing private sector investment into research and development.

As part of this, he will develop and implement strategies for investments that promote the UK as a global leader in research and development (R&D) and technologies of the future. This will help cement the UK’s place as a global science superpower.

The appointment comes at a time when innovation is being recognised as a key driver of the UK’s post-pandemic growth strategy. Innovate UK is set to play a strategically important role in this and build closer connections with industry.

Whilst we know, in words, what our SDC can do against human lung cells, as they say - a picture paints a thousand words, the scientific publication should be enlightening.
Whether or not they can withhold this data I don't know, it was government part funded so they will obviously have the insight but I wonder how close Tim is playing these cards with other interested parties. We know they've been in discussions for a while with large pharma (IMC presentations) but this COVID work should exclude any confidentiality agreement already signed.
After all this is the general health of the world, and the economic impact of an effective treatment is worth more than any pharma could pay for Sareum.
UKRI changed CEO a few months ago and they are looking to back the right businesses under a new strategy from what I remember.
We all know the story that is soon to unfold, as a shareholder who has had his doubts about shareholder value with regards Tim and PR etc etc, at one point we touted an EGM - well we are miles away from that now, Tim knew the value and obviously knew John would deliver - I've trusted in his awkwardness and inability to fluff something up for for the good of the SP, it's taken a while but patience is key when your investing in a sub 20million mcap company - where it spent most of its life. Philosophy is; trade companies, invest in people.
Have a good weekend to all holders, hope England can continue these happy days.

Here's a nice write up
https://www.morningstar.com/articles/1017882/biopharma-companies-with-covid-19-treatments-see-10-billion-market-in-2021

If you look you'll also see VIR-7831 signed an advanced purchase agreement with Singapore.

Agile start within 2weeks, complete within 3month, advance purchase agreements after that.

In the meantime we are looking very very good, partnerships lining up outside times office, he might need security on the door.

Great news here, all expected - long time coming. Worth the wait. Agile awaits.

Come on England!! Can this year get any better.... Wait, I think it's only just beginning, on all fronts.

It's a sign: https://www.superyachttimes.com/yachts/cassandra/photos

hahahaha, I couldn't agree more

Thoth is turning into our modern-day Cassandra.

We must be getting close now, as we well know..The further arrival and desperation from new users with 1 post to save us from ourselves is outstanding - just genuine decent people trying to help us, sitting watching a share and then all of a sudden have the urge to help out shareholders by creating an account and telling us how it's going to end up.
I can't believe for one minute that anybody ever falls for this, it's actually turned into the biggest sign to buy.

For those that haven't seen this, here is the grant award a project goals:
Sareum is developing SDC-1801, a small-molecule inhibitor of kinases TYK2 and JAK1, as a potential therapeutic for a wide range of inflammatory diseases such as psoriasis, lupus and Crohn's disease. Cells signal to each other using cytokines, and SDC-1801 works by blocking specific cytokine signalling pathways, leading to reduced
inflammation.

Covid-19 is caused by the virus SARS-CoV-2, and usually results in a mild disease that resolves on its own. However, some patients develop a potentially fatal severe disease due to inflammation arising from a 'cytokine storm' overreaction of the immune system leading to Acute Respiratory Distress Syndrome (ARDS), requiring intensive care. A major inflammatory pathway over activated in severe Covid-19 patients, known as Interferon Type 1, is blocked by SDC-1801\. We believe that SDC-1801 could therefore benefit severe phase Covid-19 patients by blocking Interferon Type 1 signals and reducing the inflammation during 'cytokine storm'.

Furthermore, inhibiting the kinase TYK2 has been shown to reduce bacterial pneumonia in influenza patients. We believe SDC-1801 will have the same effect in Covid-19 patients, potentially reducing the levels of bacterial infection that have been seen in up to 50% of Covid-19 patients.

The aim of this research is to investigate the effects of SDC-1801 on cytokine signalling after human cells are infected with SARS-CoV-2 to ensure that the Interferon Type 1 pathway can be blocked in this disease. We will also use mouse models to investigate whether SDC-1801 can reduce bacterial pneumonia after SARS-CoV-2 infection. If
this research is successful, we would aim to begin a clinical trial of SDC-1801 in severe-phase Covid-19 patients during 2021\.
"
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/986524/Competition_Results_-_UKRI_Ideas_to_Address_COVID-19_Innovate_UK_de_minimis_Aug_2020.pdf

Last update confirmed that it does indeed block the pathway, next update and full data release on the mouse model due July.

Thinking about the story the best previous example is that of BioNTech, nobody knew that name previously, now it's a household name. Directors billionaires, shareholders not far behind. I think we are the BioNTech of therapeutics, partnering with a major on COVID should be our next step.

Hi RMM, I think the problem, another "nice problem to have" will be the supply, hence the scarcity and the forthcoming knee-jerk reactions to place orders to give the one thing we need, not only as a country trying to come out of lockdowns but as a world trying to prevent deaths - hope. Treatments to date aren't making the same headlines as the vaccines have, and when we know the virus will continue to mutate the need for a treatment that is not a repurposed drug is huge, especially in pill form. When you think about the story that is going to evolve, for people to say news is priced in is very short-sighted.

What I think we may be overlooking is the potential for world interest in our pill post this research update which is due start of July. As we expect it will go straight into AGILE but what we haven't mentioned is the interest of other world oganisations. Yes, UK will take it through trials but it will also allow Sareum to open up huge revenue streams selling this pill to the world and allowing them to put it through it's paces in their own trials. If you remember China were vaccinating people without a completed PIII. So expect the unexpected as desperation for a treatment in the poorer regions and especially Brazil will be jumped on. Delivering a vaccine to everyone in these countries comes with huge logistical complications, send a box of pills and COVID tests does not. If you test positive and have symptoms, take a pill, if the symptoms get worse, double the dose. In theory this would reduce the amount of people needing hospital or dying, so far the theory around TYK2 has been proven, governments will want to secure this pill as a matter of basic scarcity.
Nothing is stopping Sareum from having contracts with other countries for the supply of SDC-1801, that's also why the patents are of such importance. Sareum would see huge eye-watering revenues within weeks. World governments bought everything else, masks, tests, vaccines - why wouldn't they buy a pill which has so far passed the tests within the UK framework of drug discovery.

https://uk.finance.yahoo.com/news/uk-investors-buying-sareum-holdings-071621824.html

it's +8.5% time of writing, all the delayed trades published, explaining the drop this morning, looks positive imo.

L2 very Bullish