Member Info for Northern_Monkey

Dusterhater, plenty of interest here, sounds like a desperate attempt to get a lower entry point

Decent volume today, good to see. Two large trades that look like buys just before 4pm today, two tranches of 125k shares costing just under £53k each, a good sign. As the saying goes, follow the money..

I get the feeling this has dropped back under the radar now after the price spike week before last, but with the funds bank some big things could be happening behind the scenes. The current situation in the UK, Europe and the USA will be with us for some time yet.

Nice morning here, bounce from being previously oversold imo . If it can react like this from just a bounce, how will it react if we get some positive test news? Holding firm

We are now below the placing price , which seems crazy but maybe punishment from the market. However I will say it again, they banked $10m from it, a good chunk of which should have gone to the expediting of TZLS-501. Worth noting also that just back in January the exec chairman bought 12500 shares at 43p.

After just watching the PM’s latest news conference just now there is clearly a lot happening in the background in regard to tests and treatments for Covid-19. Obviously there will be a period of radio silence from any company that may be involved. Whether TILS is pushing TZLS 501 who knows, would be nice to think so. Hopefully hear an update next week.

Price action this morning confirms to me that those large trades at end of play yesterday must of been buys.

Once again today we have some late larger trades showing up, two 15k share trades just 47 seconds before the closing bell, and another 15k share trade just under 12 minutes before the closing bell. The later two were at 35p the earlier at 36p. Now i would automatically assume they were sells, however I was offered just over 30p for around 5k shares near the close. Could someone be accumulating here ? Certainly been a pattern over the last few days.

You wont see any of the recent placement shares being sold at the current price, they will want a decent return for the $10m they have just invested this week. Had a small top up here today which showed up as a sell. A sniff of any positive test news and it will have a big impact.

The trades of 10k shares showing after hours today at a price of 42p. Possibly would towards sells, however you would have thought the price would have then dropped. If buys, then a good sign.

*since

That’s how I read it comek, the rns describes it as ‘fully human’ . The ceo in the interview seemed to push this point. They had had the drug licence once 2017 so one would assume research was well advanced before the expediting last week.

So we have dropped lower today to pretty much the latest placing price. The main question i have asked myself today is this, would investors have handed over $10m in exchange for shares where there is no gain to be had ? of course they wouldn't, even in normal market conditions, which we are far away from. Raising that amount in the current market takes some doing so they had to have seen to encouraging developments in the pipeline you would have thought.

I am expecting a renewal in interest here tomorrow. News is developing every hour worldwide with cases numbers and sadly deaths both rising. There is so much information and mis information out there regarding covid-19 , one thing is for sure , that it will be with us for a while yet. The world needs medicines/vaccines to help treat and prevent corona. TILS may well have something here, the RNS last week could be the starting point of a very big move, we will have to wait and see.

That’s a decision you must make with the information we have at our disposal. Numerous scenarios could play out here, it could fizzle out, it could go pop. It’s certainly one to watch as it would move quickly on any positivity. Watching Trumps press conference earlier, who would ever have thought that you would here this: from bbc news

‘ The US Health Secretary Alex Azar and health officials can waive certain laws and license requirements, giving more flexibility to healthcare providers’

If you are invested here or are thinking of investing have a watch of this interview from 2 days ago
https://www.youtube.com/watch?v=mn0Uo4hoclE&t=303s

It is clear that TZLS--501 does have some good advantages over its competitors

Well that was an interesting week. Having sat back now and taken in what has happened over the last few days we now sit here at a share price of 60p. We are now firmly in the grips of the outbreak in Europe with the USA following. We spiked upto over 160p on the RNS that TILS is expediting (Basically fast tracking) the development of TZLS-501,

'The Company entered into a world-wide license for composition-of-matter of TZLS-501, a fully human mAb targeting IL-6R, with Novimmune, SA, a Swiss biotechnology company in 2017. '

So my interpretation of the above snippet is that TZLS-501 has been with us for a while so they should already have extensive knowledge about its possible uses, hence the RNS.

We have drifted back down sharply since, to be expected I suppose as currently this share will be very largely news driven. The RNS the following day to raise $10m I suppose took advantage of the rise in sentiment, and they stated the that the funds will go towards the fast track clinical development of TZLS-501 and working capital/other corporate purposes.

Covid 19 will be the news focus for a while yet and hopefully TILS will be hard at work testing. Make no mistake we need news for this to move but if we do get news and its positive I wouldn't want to say where the price could stop. There is obvious risk here due to the nature, I hold a position here and will do so until we have a fuller picture. Getting $10m in a raise in this climate would be a big achievement so would have thought they would see the potential here.

Gabriele Cerrone, chairman, added that Tiziana only became aware of the potential of its anti-IL6R mAb at the weekend after people in Naples with lung problems caused by coronavirus started to respond to treatment with Actemra.
“ We are sitting one of best anti-IL6R monoclonal antibodies on the market but had no idea it could be used for Covid-19 complications on the respiratory system as no-one had ever tried it before.”

From the RNS 11th March . 'The Company believes that the features of TZLS-501 consisting of its dual mechanism of action to inhibit signalling by the membrane-bound and soluble IL-6 receptor and the rapid depletion of circulating IL-6 cytokines, a major cause of lung damage, provides TZLS-501 with distinct advantages for treatment of COVID-19'

Placing shares not admitted until 17th March so nothing really changed here. Experienced company here And have had TZLS-501 since 2017 so know this product very well. Any positive initial tests here will provide and interesting insight.

Largest trade ive ever seen in ATM, you would assume that if someone wanted to offload 11.3m in one go the price would be much lower than 2.5 , if it was a buy you would think it would be higher. Very interesting though and in my eyes is a positive, will be looking to add more tomorrow.