RE: same pre|CISION™ substrate?01 Jul 2022 10:46
Thanks for the useful replies.
In my notes, I spotted this extract from this board a few days back
"I suppose the 5140 part is the key that fits in the FAPa lock. This would be because it has the right shape and chemical characteristics (hydrogen bonds, delocalised electons, positive and negative attractions) to interact with FAPa 's chemical structure and hold AVA6000 in place so that FAPa can pull on it enough to catalyse the hydrolysis of the link to the doxorubicin part. It must be this 5140 part that is the key as it is the only part that is common to all Avacta's prodrugs. It is the essence of the IP."
That all makes good sense, especially when coupled with "pre|CISION is designed to be a highly specific substrate for FAPa", which is an extract from a slide showing around 3:38 in https://avacta.wistia.com/medias/kv40kul5b2