RE: Cancer treatment16 Dec 2020 11:07
Rollout of nucleic acid-based therapies is hindered by the need to
store the vaccine at ultra-low temperatures. Pfizer’s mRNA based COVID-19 vaccine
requires storage at -70 °C. Initial studies have demonstrated that Nuvec®, loaded with
pDNA, can be dried, stored at room temperature and reconstituted without any
degradation of the pDNA payload. The formulation is now being stored over different
periods of time, after which it will be reconstituted and tested in vitro to evaluate if cell
transfection (the ability to introduce the pDNA into the target cell) has been maintained.
The ability of Nuvec® to be stored at room temperature without affecting its
effectiveness would be of significant interest to developers of nucleic acid-based
treatments