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Thanks both,
Study still ongoing, I'm not quite learned in the process of transformation in study to product.
Just noticed as new inhibitors on selleckchem where all are validated for efficacy and effectiveness demonstrated through pre clinical and clinical and fda approved.
Appreciate your responses
https://www.selleckchem.com/products/sar-20347.html
On for sale as medication? Not quite understanding
Aurora kinases are a family of highly conserved serine-threonine protein kinases that have a key role in mitosis; overexpression of Aurora A has been consistently demonstrated in AML cell lines and patient cohorts [73]. Aurora kinase inhibitors were identified as promising agents in the treatment of FLT3-ITD-associated AML [73], providing a rationale for the development of dual FLT3-Aurora kinase inhibitors. The dual Aurora/FLT3 inhibitor CCT137690 (Figure 5) was identified following a medicinal chemistry program starting from an in-house Aurora inhibitor series [74] and was shown to inhibit the growth of FLT3 inhibitor-resistant AML cell lines [73]. CCT241736 (Figure 5) is a more advanced analog of CCT137690, with a favorable selectivity and PK profile and no hERG inhibition [74]. CCT241736 has significant in vivo efficacy against FLT3-ITD human tumor xenograft models and against FLT3-ITD cells with high in vitro relative resistance to the FLT3 inhibitors quizartinib and sorafenib. CCT241736 was also effective on primary samples from AML patients, including those with disease resistance to FLT3 inhibitor quizartinib [75]. Ilorasertib (ABT-348; Figure 5), an Aurora/VEGF inhibitor also potent against FLT3 [76], demonstrated clinical response in 3 out of 38 AML patients in a Phase 1 dose-escalation clinical study [77].
Under heading investment thesis - valuation
Wondering whether this modelling still applies
https://quoteddata.com/research/sareum-holdings-tyking-nicely-2/
https://www.londonstockexchange.com/news-article/SAR/final-results/14717306?lang=en
Plain and simple, hopefully tomorrow
https://www.tipranks.com/news/shell-buys-50-stake-in-natural-gas-blocks-from-colombias-ecopetrol/